Bracken fern-induced malignant tumors in rats: Absence of mutations in p53, H-ras and K-ras and no microsatellite instability

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 499, Issue 2, 2002, Pages 189-196

  Freitas, Renata N ^a,b   Brasileiro Filho, Geraldo ^b   Silva, Marcelo E ^a   Pena, Sérgio D J ^b  

^a FEDERAL UNIVERSITY OF OURO PRETO   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Bracken fern carcinogenesis; Microsatellite instability; Mutation; p53; ras

Indexed keywords

DNA; MOLECULAR MARKER; PROTEIN P53; RAS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA SEQUENCE; EPIDEMIOLOGICAL DATA; EXON; FEMALE; FERN; GENE AMPLIFICATION; GENE MUTATION; MALIGNANT NEOPLASTIC DISEASE; MICROSATELLITE INSTABILITY; MOLECULAR MODEL; MUTATION; NONHUMAN; NUCLEOTIDE REPEAT; ONCOGENE; PRIORITY JOURNAL; RAT; TUMOR SUPPRESSOR GENE; VALIDATION PROCESS;

ANIMALS; CARCINOGENS; DNA MUTATIONAL ANALYSIS; DNA PRIMERS; DNA, NEOPLASM; FEMALE; GASTROINTESTINAL NEOPLASMS; GENES, P53; GENES, RAS; GENES, TUMOR SUPPRESSOR; MICROSATELLITE REPEATS; MUTATION; PLANT EXTRACTS; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; URINARY BLADDER NEOPLASMS;

ANIMALIA; FILICOPHYTA; PTERIDIUM; PTERIDIUM AQUILINUM;

EID: 0037138456     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(01)00275-5     Document Type: Article

References (31)

1. The bracken problem: A global perspective
2. Carcinogenic activity of bracken
3. Bracken fern (Pteridium aquilinum) and some of its constituents
4. The induction of neoplasms of the urinary bladder of the cow and the small intestine of the rat by feeding bracken fern (Pteris aquilinia)
5. Bracken fern (Pteridium aquilinum) consumption and oesophageal and stomach cancer in the Ouro Preto region, Minas Gerais, Brazil
6. Diet and Cancer
7. Gastric cancer in Gwynedd: Possible links with bracken
8. Bracken ptaquiloside in milk
9. Carcinogenic effects in mice of milk from cows fed on bracken fern Pteridium aquilinum
10. Fern spore extracts can damage DNA
11. Possible association between gastric cancer and bracken fern in Venezuela: An epidemiologic study
12. Bracken derived carcinogens as affecting animal and human health in Costa Rica
13. Genetic instability and Darwinian selection in tumours
14. Mismatch repair defects in human carcinogenesis
15. The multistep nature of cancer
16. Instability of microsatellites in rat colon tumors induced by heterocyclic amines
17. Rat gene mapping using PCR-analyzed microsatellites
18. Genetic and population study of an Y-linked tetranucleotide repeat DNA polymorphism with a simple non-isotopic technique
19. Induction of tumours in rats by bracken fern (Pteridium aquilinum) from Ouro Preto (Minas Gerais, Brazil)
20. Oncogenicity of bracken fern (Pteridium aquilinum) from Ouro Preto, Brazil, for rats fed low animal protein diets
21. Tumorigenicity of boiling water extract of bracken fern (Pteridium aquilinum)
22. The effect of pretreatment with vitamin E on bracken tumorigenicity in rats
23. Bracken Carcinogenicity
24. TP53 tumor suppressor gene: A model for investigating human mutagenesis
25. A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild type but not from oncogenic mutant p53 protein
26. H-ras activation is an early event in the ptaquiloside-induced carcinogenesis: Comparison of acute and chronic toxicity in rats
27. Mechanism of bracken fern carcinogenesis: Evidence for H-ras activation via initial adenine alkylation by ptaquiloside
28. Bat-26, an indicator of the replication error phenotype in colorectal cancer and cell lines
29. A National Cancer Institute Workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
30. Microsatellite instability as a tool for the classification of gastric cancer