A 3D QSAR study of a series of HEPT analogues: The influence of conformational mobility on HIV-1 reverse transcriptase inhibition

Journal of Medicinal Chemistry

Volumn 40, Issue 26, 1997, Pages 4257-4264

  Kireev, Dmitri B ^a   Chrétien, Jacques R ^a   Grierson, David S ^b   Monneret, Claude ^c  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(2 HYDROXYETHOXY)METHYL] 6 (PHENYLTHIO)THYMINE; CHLORPHENOTANE; DIDANOSINE; EMIVIRINE; LAMIVUDINE; NEVIRAPINE; PYRIDONE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TNK 651; UNCLASSIFIED DRUG; ZIDOVUDINE;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG CONFORMATION; ENZYME INHIBITOR INTERACTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION;

ANTI-HIV AGENTS; DRUG DESIGN; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PROTEIN BINDING; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THYMINE;

EID: 0031449527     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970110p     Document Type: Article

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