Structure-activity relationships of an inhibitory nematode FMRFamide-related peptide, SDPNFLRFamide (PF1), on Ascaris suum muscle

International Journal for Parasitology

Volumn 32, Issue 14, 2002, Pages 1765-1771

  Bowman, Jerry W ^a   Friedman, Alan R ^a   Thompson, David P ^a   Maule, Aaron G ^b   Alexander Bowman, Susan J ^a   Geary, Timothy G ^a  

^a PFIZER INC   (United States)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Ascaris suum; Body wall muscle; FaRP; FMRFamide related peptide; SDPNFLRFamide; Structure activity relationship

Indexed keywords

ALANINE; AMIDE; BETAINE; CHLORIDE CHANNEL; HEXAPEPTIDE; ISOPROTEIN; LEUCINE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PHENYLALANINE; PHENYLALANYLMETHIONYLARGINYLPHENYLALANINAMIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; HELMINTH PROTEIN; PEPTIDE FRAGMENT; SDPNFLRFAMIDE;

NEMATODE; PARASITOLOGY;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASCARIS SUUM; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CONTROLLED STUDY; ELECTROPHYSIOLOGY; MUSCLE; MUSCLE TISSUE; MUSCLE TONE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; ANIMAL; CELL MEMBRANE POTENTIAL; CHEMISTRY; DRUG EFFECT; METABOLISM; MUSCLE CONTRACTION; PHYSIOLOGY; SKELETAL MUSCLE;

ASCARIS SUUM; CAENORHABDITIS ELEGANS; NEMATODA;

ANIMALS; ASCARIS SUUM; CHLORIDE CHANNELS; FMRFAMIDE; HELMINTH PROTEINS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MUSCLE CONTRACTION; MUSCLE, SKELETAL; PEPTIDE FRAGMENTS; POTASSIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037137565     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(02)00213-8     Document Type: Article

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