In vitro and in vivo antagonistic activities of SM-31900 for the NMDA receptor glycine-binding site

Brain Research

Volumn 944, Issue 1-2, 2002, Pages 165-173

  Ohtani, Ken ichi ^a   Tanaka, Hiroyasu ^a   Yoneda, Yukio ^b   Yasuda, Hirokazu ^a   Ito, Akira ^a   Nagata, Ryu ^a   Nakamura, Mitsutaka ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

Antagonist; Glutamate excitotoxicity; Glycine binding site; Neuroprotective; NMDA receptor; SM 31900

Indexed keywords

5,7 DICHLORO 1,2,3,4 TETRAHYDRO 4 (3 PHENYLUREIDO) 2 QUINOLINECARBOXYLIC ACID; 5,7 DICHLOROKYNURENIC ACID; 7 CHLORO 3 [2 (1 CARBOXYETHOXY) 4 AMINOMETHYLPHENYL]AMINOCARBONYLMETHYL 1,3,4,5 TETRAHYDROBENZ[C,D]INDOLE 2 CARBOXYLIC ACID; 7 CHLOROKYNURENIC ACID; DIZOCILPINE; GLUTAMIC ACID; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RADIOLIGAND; SM 31900; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG BINDING SITE; DRUG EFFECT; DRUG INHIBITION; DRUG POTENCY; DRUG RECEPTOR BINDING; IN VITRO STUDY; IN VIVO STUDY; MALE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

AMINOQUINOLINES; ANIMALS; BINDING, COMPETITIVE; BRAIN; CELLS, CULTURED; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; FETUS; GLUTAMIC ACID; INDOLES; KYNURENIC ACID; MALE; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, GLYCINE; RECEPTORS, N-METHYL-D-ASPARTATE; SEIZURES;

EID: 0037135107     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)02741-5     Document Type: Article

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