Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain

Neuroscience

Volumn 109, Issue 1, 2002, Pages 5-14

  Baxter, H C ^a   Liu, W G ^b   Forster, J L ^a   Aitken, A ^a   Fraser, J R ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

Author keywords

CNS; Immunocytochemistry; Neurodegeneration; Prion

Indexed keywords

ISOPROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY LABELING; ANTIBODY SPECIFICITY; ARTICLE; BRAIN; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; GRAY MATTER; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOLOCALIZATION; MOUSE; NERVE CELL; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SCRAPIE AGENT; STRAIN DIFFERENCE; THALAMUS; VIRUS INFECTION;

14-3-3 PROTEINS; ANIMALS; BRAIN; CELL MEMBRANE; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; NEURONS; PROTEIN ISOFORMS; PRPSC PROTEINS; SCRAPIE; SERINE ENDOPEPTIDASES; TYROSINE 3-MONOOXYGENASE;

EID: 0037127035     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00492-4     Document Type: Article

References (35)

1. 14-3-3 and its possible role in co-ordinating multiple signalling pathways
2. 14-3-3 alpha and delta are the phosphorylated forms of raf-activating 14-3-3 beta and zeta. In vivo stoichiometric phosphorylation in brain at a Ser-Pro-Glu-Lys motif
3. Transmission of bovine spongiform encephalopathy and scrapie to mice: Strain variation and the species barrier
4. 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage
5. Association of GABA(B) receptors and members of the 14-3-3 family of signaling proteins
6. Increased levels of 14-3-3 gamma and epsilon proteins in brain of patients with Alzheimer's disease and down syndrome
7. Hydrated autoclave pretreatment enhancement of prion protein immunoreactivity in formalin-fixed bovine spongiform encephalopathy-affected brain
8. Evidence of presynaptic location and function of the prion protein
9. The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies
10. Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases
11. Chemistry and cell biology of neuron- and glia-specific proteins
12. Early unsuspected neuron and axon terminal loss in scrapie-infected mice revealed by morphometry and immunocytochemistry
13. In vivo toxicity of prion protein in murine scrapie: Ultrastructural and immunogold studies
14. Synapse loss associated with abnormal PrP precedes neuronal degeneration in the scrapie-infected murine hippocampus
15. Scrapie infection alters the membrane and synaptic properties of mouse hippocampal CA1 pyramidal neurones
16. Alterations in potassium currents may trigger neurodegeneration in murine scrapie
17. Synaptic plasticity in the CA1 area of the hippocampus of scrapie-infected mice
18. Expression and structural analysis of 14-3-3 proteins
19. An enzyme-linked immunosorbent assay to quantify 14-3-3 proteins in cerebral fluid of suspected Creutzfeldt-Jakob disease patients
20. Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins
21. The assay development of a molecular marker for transmissible spongiform encephalopathies
22. Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies
23. Immunolocalization of the cellular prion protein in normal brain
24. Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine
25. Visual system
26. 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules
27. Molecular cloning of cDNA to rat 14-3-3 eta chain polypeptide and the neuronal expression of the mRNA in the central nervous system
28. Developmental regulation of neuronal expression for the eta subtype of the 14-3-3 protein, a putative regulatory protein for protein kinase C
29. Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain
30. Pathology of cerebrospinal fluid and interstitial fluid of the CNS: Significance for Alzheimer disease, prion disorders and multiple sclerosis
31. Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
32. The structural basis for 14-3-3:phosphopeptide binding specificity
33. Analysis of EEG and CSF 14-3-3 proteins as aids to the diagnosis of Creutzfeldt-Jakob disease
34. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)