Acetylcholine receptors are required for agrin-induced clustering of postsynaptic proteins

EMBO Journal

Volumn 20, Issue 24, 2001, Pages 7060-7073

  Marangi, P Angelo ^a   Forsayeth, John R ^b   Mittaud, Peggy ^a   Erb Vögtli, Susanne ^a   Blake, Derek J ^c   Moransard, Martijn ^a   Sander, Andreas ^d   Fuhrer, Christian ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b ELAN PHARMACEUTICALS   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

Acetylcholine receptor; Agrin; Neuromuscular junction; Postsynaptic apparatus; Rapsyn

Indexed keywords

AGRIN; CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR ANTIBODY; DYSTROGLYCAN; RAPSYN; SYNTROPHIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; MYOTUBE; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN LOCALIZATION; PROTEIN STABILITY; RAT; RECEPTOR DOWN REGULATION;

AGRIN; ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; IMMUNOHISTOCHEMISTRY; MUSCLE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CHOLINERGIC; SYNAPSES;

ANIMALIA;

EID: 0037126630     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.24.7060     Document Type: Article

References (42)

1. Absence of α-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin
2. Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex
3. Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold
4. Use of a replica technique to isolate muscle cell lines defective in expressing the acetylcholine receptor
5. Genetic variants of C2 muscle cells that are defective in synthesis of the α subunit of the acetylcholine receptor
6. Agrin-induced phosphorylation of the acetylcholine receptor regulates cytoskeletal anchoring and clustering
7. Accumulation of acetylcholine receptors is a necessary condition for normal accumulation of acetylcholinesterase during in vitro neuromuscular synaptogenesis
8. An amino-terminal extension is required for the secretion of chick agrin and its binding to extracellular matrix
9. Postsynaptic clustering of major GABAA receptor subtypes requires the γ2 subunit and gephyrin
10. The postsynaptic 43K protein clusters muscle nicotinic acetylcholine receptors in Xenopus oocytes
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13. Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice
14. Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
15. Rapsyn clusters and activates the synapse-specific receptor tyrosine kinase MuSK
16. Agrin acts via a MuSK receptor complex
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18. Acetylcholine receptors are required for postsynaptic aggregation driven by the agrin signalling pathway
19. A mechanism for acetylcholine receptor clustering distinct from agrin signaling
20. Acetylcholine receptor in a C2 muscle cell variant is retained in the endoplasmic reticulum
21. The dystroglycan complex is necessary for stabilization of acetylcholine receptor clusters at neuromuscular junctions and formation of the synaptic basement membrane
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27. Differential targeting of components of the dystrophin complex to the postsynaptic membrane
28. Role for a synapse-specific carbohydrate in agrin-induced clustering of acetylcholine receptors
29. The agrin hypothesis
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31. Agrin-induced activation of AChR-bound Src family kinases requires rapsyn and correlates with AChR clustering
32. Src-class kinases act within the agrin/MuSK pathway to regulate acetylcholine receptor phosphorylation, cytoskeletal anchoring and clustering
33. Characterisation of α-dystrobrevin in muscle
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36. Mechanism of nicotinic acetylcholine receptor cluster formation by rapsyn
37. Gene transfer into individual muscle fibers and conditional gene expression in living animals
38. Development of the vertebrate neuromuscular junction
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40. Agrin-induced specializations contain cytoplasmic, membrane and extracellular matrix-associated components of the postsynaptic apparatus
41. Metabolic stabilization of muscle nicotinic acetylcholine receptor by rapsyn
42. Pathfinding and synapse formation in a zebrafish mutant lacking functional acetylcholine receptors