Effects of striatal injections of GABAA receptor agonists and antagonists in a genetic animal model of paroxysmal dystonia

European Journal of Pharmacology

Volumn 443, Issue 1-3, 2002, Pages 59-70

  Hamann, Melanie ^a   Richter, Angelika ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Basal ganglion; Dyskinesia; Movement disorder; Striatum

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; BICUCULLINE; FLUMAZENIL; FLURAZEPAM; MUSCIMOL; PENTETRAZOLE; PHENOBARBITAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFECT; DYSTONIA; FEMALE; GABAERGIC SYSTEM; MALE; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL;

EID: 0037123873     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01546-7     Document Type: Article

References (46)

1. sz mutants
2. Synaptic input and output of parvalbumin-immunoreactive neurons in the neostriatum of the rat
3. Selective innervation of neostriatal interneurons by a subclass of neuron in the globus pallidus of the rat
4. The behavioral and motor consequences of focal lesions of the basal ganglia in man
5. Expression of cholecystokinin, somatostatin, thyrotropin-releasing hormone, glutamic acid decarboxylase and tyrosine hydroxylase genes in the central nervous motor systems of the genetically dystonic hamster
6. Further evidence for a functional dorsal-ventral division of the rat striatum: GABAergic involvement in oral movements
7. Paroxysmal dyskinesias: Clinical features and classification
8. Medical treatment of dystonia
9. Classification of dystonia
10. The spontaneous seizures genotype sz in hamsters as a disease model of benzodiazepine deficits
11. Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia
12. A receptor subunits in the striatum of the rat
13. Quantitative EEG analysis of depth electrode recordings from several brain regions of mutant hamsters with paroxysmal dystonia discloses frequency changes in the basal ganglia
14. Alterations in spontaneous single unit activity of striatal subdivisions during ontogenesis in mutant dystonic hamsters
15. Deficit of striatal parvalbumin-reactive GABAergic interneurons and decreased basal ganglia output in a genetic rodent model of idiopathic paroxysmal dystonia
16. Pharmacology of benzodiazepine antagonists
17. Striatal interneurons: Chemical, physiological and morphological characterization
18. Inhibitory control of neostriatal projection neurons by GABAergic interneurons
19. A receptor agonists, partial agonists and antagonists. Design and therapeutic prospects
20. Abnormalities in amino acid neurotransmitters in discrete brain regions of genetically dystonic hamsters
21. The sz mutant hamster: A genetic model of epilepsy or of paroxysmal dystonia?
22. Gonadal sex hormones and dystonia: Experimental studies in genetically dystonic hamsters
23. Anticonvulsant drugs: Mechanism of action
24. GABAergic synaptic transmission. Regulation by drugs
25. Functionally distinct subpopulations of striatal neurons are differentially regulated by GABAergic and dopaminergic inputs - I. In vivo analysis
26. A/benzodiazepine receptor-chloride ionophore complex in a genetic model for generalized dystonia: A quantitative autoradiographic analysis
27. 2 receptor binding in the genetically dystonic hamster
28. 3H]WIN 35,428 binding to the dopamine transporter in a hamster model of idiopathic paroxysmal dystonia
29. Drug interactions at the GABA receptor-ionophore complex
30. Regionally selective and age-dependent alterations in benzodiazepine receptor binding in the genetically dystonic hamsters
31. Therapeutic aspects of kinesigenic paroxysmal choreoathesosis and familial paroxysmal choreoathetosis of the Mount and Reback type
32. Evidence for striatal dopaminergic overactivity in paroxysmal dystonia indicated by microinjections in a genetic rodent model
33. The atypical neuroleptic clozapine exerts antidystonic activity in a mutant hamster model. Comparison with haloperidol
34. Alterations in dystonia in response to pharmacological manipulation of serotonin receptors in the genetically dystonic hamster
35. Pathophysiology of idiopathic dystonia: Findings from genetic animal models
36. Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model
37. The novel antiepileptic drug lamotrigine exerts prodystonic effects in a mutant hamster model of generalized dystonia
38. 3H]-2-Deoxyglucose uptake study in mutant dystonic hamsters: Abnormalities in discrete brain regions of the motor system
39. - ion channels modulated by multiple drug-binding sites
40. Mutational and biochemical analysis of dopamine in dystonia
41. Substantia nigra regulates action of antiepileptic drugs
42. Physiology of hypokinetic and hyperkinetic movement disorders: Model for dyskinesia
43. Neuropathological studies in a mutant hamster model of paroxysmal dystonia
44. BR1 receptor immunoreactivity