Physicochemical interaction of local anesthetics with lipid model systems - Correlation with in vitro permeation and in vivo efficacy

Journal of Controlled Release

Volumn 81, Issue 1-2, 2002, Pages 33-43

  Welin Berger, Katayoun ^a   Neelissen, Jan A M ^a   Engblom, Johan ^b  

^a ASTRAZENECA R AND D   (Sweden)

^b Box 50310   (Sweden)

Author keywords

Differential scanning calorimetry; Human stratum corneum; Lipid phase behavior; Local anesthetic; Permeation; Small and wide angle X ray diffraction

Indexed keywords

GLYCEROL OLEATE; LIDOCAINE; LIPID; LOCAL ANESTHETIC AGENT; PRILOCAINE; SAMERIDINE; SPHINGOMYELIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG EFFICACY; DRUG PENETRATION; EVALUATION; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIQUID CRYSTAL; LOCAL ANESTHESIA; MEMBRANE FLUIDITY; MORPHOLOGY; PHYSICAL CHEMISTRY; PHYSICOCHEMICAL MODEL; PRIORITY JOURNAL; SKIN PERMEABILITY; STRATUM CORNEUM; X RAY DIFFRACTION;

ANESTHETICS, LOCAL; CHEMISTRY, PHYSICAL; FEMALE; HUMANS; LIPID BILAYERS; MEMBRANES, ARTIFICIAL; MODELS, BIOLOGICAL; MODELS, CHEMICAL; PERMEABILITY; SKIN;

EID: 0037123699     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(02)00035-4     Document Type: Article

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