The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins

Journal of Cell Biology

Volumn 158, Issue 6, 2002, Pages 1017-1027

  Curran, Sean P ^a   Leuenberger, Danielle ^a   Schmidt, Einhard ^a   Koehler, Carla M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Mitochondria; Protein import; Protein translocation; Saccharomyces cerevisiae; TIM complex

Indexed keywords

MEMBRANE PROTEIN; PROTEIN TIM13P; PROTEIN TIM8P; UNCLASSIFIED DRUG; ZINC;

AMINO TERMINAL SEQUENCE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; HYDROPHOBICITY; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PURIFICATION; PROTEIN TRANSPORT;

CARRIER PROTEINS; CIRCULAR DICHROISM; DISULFIDES; ESCHERICHIA COLI; INTRACELLULAR MEMBRANES; MACROMOLECULAR SUBSTANCES; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL PROTEINS; MOLECULAR WEIGHT; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; ZINC;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0037119946     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200205124     Document Type: Article

References (49)

1. Tim9, a new component of the TIM22.54 translocase in mitochondria
2. Import of proteins into mitochondria. Partial purification of a matrix-located protease involved in cleavage of mitochondrial precursor polypeptides
3. Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein
4. The mitochondrial import receptor Tom70: Identification of a 25 kDa core domain with a specific binding site for preproteins
5. The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier
6. Tim23p contains separate and distinct signals for targeting to mitochondria and insertion into the inner membrane
7. Two intermembrane space TIM complexes interact with different domains of Tim23p during its import into mitochondria
8. Tim23 links the inner and outer mitochondrial membranes
9. Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complex
10. Isolation of highly purified mitochondria from S. cerevisiae
11. A Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of Lck
12. Chaperone activity with a redox switch
13. A novel X-linked gene, DDP, shows mutations in families with deafness (DFN-1), dystonia, mental deficiency and blindness
14. Protein translocation into mitochondria
15. Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix-targeted preproteins
16. The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane
17. Tim18p is a new component of the Tim54p-Tim22p translocon in the mitochondrial inner membrane
18. Import of mitochondrial carriers mediated by essential proteins of the intermembrane space
19. Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins
20. Human deafness dystonia syndrome is a mitochondrial disease
21. How membrane proteins travel across the mitochondrial intermembrane space
22. Tim18p, a novel subunit of the inner membrane complex that mediates protein import into the yeast mitochondrial inner membrane
23. Zinc finger proteins: New insights into structural and functional diversity
24. Different import pathways through the mitochondrial intermembrane space for inner membrane proteins
25. Zinc-dependent intermembrane space proteins stimulate import of carrier proteins into plant mirochondria
26. Zinc fingers are sticking together
27. The essential function of the small Tim proteins in the TIM22 import pathway does not depend on formation of the soluble 70-kilodalton complex
28. Mitochondrial metabolite transporters
29. Protein import into mitochondria
30. The role of the TIM8-13 complex in the import of Tim23 into mitochondria
31. Analysis of the circular dichroism spectrum of proteins using the convex constraint algorithm: A practical guide
32. Mitochondrial import: Crossing the aqueous intermembrane space
33. The carboxyl-terminal two-thirds of the ADP/ATP carrier polypeptide contains sufficient information to direct translocation into mitochondria
34. Versatility of the mitochondrial protein import machinery
35. Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex
36. Protein translocation into mitochondria
37. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria
38. Functional staging of ADP/ATP carrier translocation across the outer mitochondrial membrane
39. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa
40. Analysis of molecular masses and oligomeric states of protein complexes by blue native electrophoresis and isolation of membrane protein complexes by two-dimensional native electrophoresis
41. Common principles of protein translocation across membranes
42. The central matrix loop drives import of uncoupling protein 1 into mitochondria
43. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
44. Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5
45. A self-consistenr method for the analysis of protein secondary structure from circular dichroism
46. A de novo missense mutation in a critical domain of the X-linked DDP gene causes the typical deafness-dystonia-optic atrophy syndrome
47. The ATPase and protease domains of yeast mitochondrial Lon: Roles in proteolysis and respiration-dependent growth
48. The three modules of ADP/ATP carrier cooperate in receptor recruitment and translocation into mitochondria