DNA-mediated electron transfer across synthetic T:A·T triplex structures

Angewandte Chemie - International Edition

Volumn 41, Issue 18, 2002, Pages 3485-3487

  Lewis, Frederick D ^a   Wu, Yansheng ^a   Hayes, Ryan T ^a   Wasielewski, Michael R ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

DNA structures; Electron transfer; Fluorescence spectroscopy; Hole transport; Time resolved spectroscopy

Indexed keywords

ABSORPTION SPECTROSCOPY; DNA; ELECTRON TUNNELING; GROUND STATE;

ELECTRON DONORS;

ELECTRON TRANSITIONS;

DNA; DOUBLE STRANDED DNA; TRIPLEX DNA;

ABSORPTION SPECTROPHOTOMETRY; ABSORPTION SPECTROSCOPY; ARTICLE; CHEMISTRY; CONFORMATION; DNA SEQUENCE; DNA STRUCTURE; ELECTRON TRANSPORT; FLUORESCENCE SPECTROSCOPY; GENETICS; NUCLEOTIDE SEQUENCE; STRUCTURE ANALYSIS; TRIPLE HELIX;

DNA; ELECTRON TRANSPORT; NUCLEIC ACID CONFORMATION;

EID: 0037119725     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3773(20020916)41:18<3485::AID-ANIE3485>3.0.CO;2-9     Document Type: Article

References (16)

1. E. Wang, J. Feigon in Nucleic Acid Structure (Ed.: S. Neidle). Oxford, Oxford, 1999.
2. M. Tarköy, A. K. Phillips, P. Schultze, J. Feigon, Biochemistry 1998, 37, 5810.
3. M. Salunkhe, T. Wu, R. L. Letsinger, J. Am. Chem. Soc. 1992, 114, 8768.
4. R. Macaya, E. Wang, P, Schultze, V. Sklenár, J. Feigon, J. Mol. Biol. 1992, 225-755.
5. F. D. Lewis, T. Wu, X. Liu, R. L. Letsinger, S. R. Greenfield, S. E. Miller, M. R. Wasielewski, J. Am. Chem. Soc. 2000, 122, 2889.
6. F. D. Lewis, X. Liu, Y. Wu, S. E. Miller, M. R. Wasielewski, R. L. Letsinger, R. Sanishvili, A. Joachimiak, V. Tereshko, M. Egli, J. Am. Chem. Soc. 1999, 121, 9905.
7. Data provided as Supporting Information.
8. Detailed information concerning the synthesis and characterization of triplex-forming conjugates will be reported separately. The UV thermal dissociation and circular dichroism spectra of 2-5 are consistent with the assignment of triplex structures. In the case of 1, the structure may be an end-capped hairpin rather than a triplex.
9. cs can also be calculated from fluorescence quantum-yield data. However, these values are considered to be less reliable than those obtained from transient decay measurements (Table 1), because imperfectly folded conformations of the conjugates should have high fluorescence quantum yields.
10. F. C. Grozema, Y. A. Berlin, L. D. A. Siebbeles, J. Am. Chem. Soc. 2000, 122, 10903.
11. G. S. M. Tong, I. V. Kurnikov, D. N. Beratan, J. Phys. Chem. B 2002, 106, 2381.
12. K. Kawai, Y. Wata, N. Ichinose, T. Majima, Angew. Chem. 2000, 112, 4497; Angew. Chem. Int. Ed. 2000, 39, 4327.
13. K. Kawai, Y. Wata, N. Ichinose, T. Majima, Angew. Chem. 2000, 112, 4497; Angew. Chem. Int. Ed. 2000, 39, 4327.
14. F. D. Lewis, X. Liu, J. Liu, S. E. Miller, R. T. Hayes, M. R. Wasielewski, Nature 2000, 406, 51.
15. [15] have investigated strand cleavage resulting from hole migration in triplex DNA.
16. Y. Kan, G. B. Schuster, J. Am. Chem. Soc. 1999, 121, 11607.