Novel inhibitors of AP-1 and NF-κB mediated gene expression: Structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)pyrimidine-5-carb oxylate

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 15, 2000, Pages 1645-1648

  Palanki, Moorthy S S ^a   Erdman, Paul E ^a   Manning, Anthony M ^a   Ow, Arnold ^a   Ransone, Lynn J ^a   Spooner, Cheryl ^a   Suto, Carla ^a   Suto, Mark ^a  

^a CELGENE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR AP 1;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG ANTAGONISM; DRUG INHIBITION; DRUG SYNTHESIS; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

GENE EXPRESSION REGULATION; HUMANS; JURKAT CELLS; MALEIMIDES; NF-KAPPA B; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTOR AP-1;

EID: 0034618236     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00312-7     Document Type: Article

References (10)