Spinal cord heme oxygenase participates in glutamate-induced pain-related behaviors

European Journal of Pharmacology

Volumn 450, Issue 1, 2002, Pages 43-48

  Li, Xiangqi ^a   Clark, J David ^a  

^a VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

cGMP; Glutamate; Guanylate cyclase; Heme oxygenase; Metalloporphyrin; Null mutant

Indexed keywords

6 ANILINO 5,8 QUINOLINEQUINONE; 8 BROMO CYCLIC GMP; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CHROMIUM MESOPORPHYRIN; CYCLIC GMP; GLUTAMATE RECEPTOR AGONIST; GLUTAMIC ACID; HEME OXYGENASE; HEME OXYGENASE 2; HEME OXYGENASE INHIBITOR; N METHYL DEXTRO ASPARTIC ACID; NEUROTRANSMITTER; PROTOPORPHYRIN TIN; UNCLASSIFIED DRUG; AMINO ACID RECEPTOR STIMULATING AGENT; HEME OXYGENASE-2; MESOPORPHYRIN; METALLOPORPHYRIN; N METHYLASPARTIC ACID; PROTOPORPHYRIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BITE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; DRUG SELECTIVITY; ENZYME ACTIVATION; LICKING; MALE; MOUSE; NONHUMAN; PAIN; PRIORITY JOURNAL; SCRATCHING; SPINAL CORD; WILD TYPE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; COMPARATIVE STUDY; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; IN VITRO STUDY; INTRASPINAL DRUG ADMINISTRATION; METABOLISM; MOUSE MUTANT; PSYCHOLOGICAL ASPECT;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMAL; BEHAVIOR, ANIMAL; COMPARATIVE STUDY; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; GLUTAMIC ACID; HEME OXYGENASE (DECYCLIZING); IN VITRO; INJECTIONS, SPINAL; MALE; MESOPORPHYRINS; METALLOPORPHYRINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; N-METHYLASPARTATE; PAIN; PROTOPORPHYRINS; SPINAL CORD; ANIMALS;

EID: 0037118907     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)02051-4     Document Type: Article

References (29)

1. Intrathecal N-methyl-D-aspartate (NMDA) induces paradoxical analgesia in the tail-flick test in rats
2. Selective inhibition of heme oxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations
3. Pharmacological characterization of AMPA-induced biting behaviour in mice
4. Differential modulatory roles of cholera toxin and pertussis toxin in the regulation of pain responses induced by excitatory amino acids administered intrathecally in mice
5. Contribution of protein kinase C to central sensitization and persistent pain following tissue injury
6. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury
7. Differential localization of heme oxygenase and NADPH-diaphorase in spinal cord neurons
8. The role of systemic, spinal and supraspinal L-arginine-nitric oxide-cGMP pathway in thermal hyperalgesia caused by intrathecal injection of glutamate in mice
9. Intrathecal injection of cell-permeable analogs of cyclic 3′,5′-guanosine monophosphate produces hyperalgesia in mice
10. Soluble guanylate cyclase: The forgotten sibling
11. Intrathecal morphine in mice: A new technique
12. Activation of spinal N-methyl-D-aspartate receptors stimulates a nitric oxide/cyclic guanosine 3,5-monophosphate/glutamate release cascade in nociceptive signaling
13. Cyclic GMP pathway is critical for inducing long-term sensitization of nociceptive sensory neurons
14. Heme oxygenase type 2 plays a role in formalin-induced nociception
15. The role of heme oxygenase in neuropathic and incisional pain
16. Heme oxygenase inhibitors reduce formalin-induced Fos expression in mouse spinal cord tissue
17. Spinal cord nitric oxide synthase and heme oxygenase limit morphine induced analgesia
18. Antinociceptive involvement of substance P in the spinal cord of mice: Dose effects of substance P on the behavior elicited by intrathecally administered NMDA
19. Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat
20. Investigations of the possible role for carbon monoxide (CO) in thermal and mechanical hyperalgesia in the rat
21. Involvement of glutamate receptors in allodynia induced by prostaglandins E2 and F2 alpha injected into conscious mice
22. The NO-cGMP pathway in neonatal rat dorsal horn
23. Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice
24. Activation of cGMP-dependent protein kinase Ialpha is required for N-methyl-D-aspartate- or nitric oxide-produced spinal thermal hyperalgesia
25. Expression and action of cyclic GMP-dependent protein kinase Ialpha in inflammatory hyperalgesia in rat spinal cord
26. Localization and age-related changes of nitric oxide- and ANP-mediated cyclic-GMP synthesis in rat cervical spinal cord: An immunocytochemical study
27. Zinc protoporphyrin IX, an inhibitor of the enzyme that produces carbon monoxide, blocks spinal nociceptive transmission evoked by formalin injection in the rat
28. Differential effects of NMDA and group I mGluR antagonists on both nociception and spinal cord protein kinase C translocation in the formalin test and a model of neuropathic pain in rats
29. Differential effects of NMDA and group I mGluR antagonists on both nociception and spinal cord protein kinase C translocation in the formalin test and a model of neuropathic pain in rats