An assessment of the association between IL-2 gene polymorphisms and Japanese patients with multiple sclerosis

Journal of the Neurological Sciences

Volumn 205, Issue 1, 2002, Pages 47-50

  Kikuchi, Seiji ^a   Niino, Masaaki ^a   Fukazawa, Toshiyuki ^b   Yabe, Ichiro ^a   Tashiro, Kunio ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Hokuyukai Neurology Hospital   (Japan)

Author keywords

Genetics; Interleukin 2; Japanese; Multiple sclerosis; Polymorphism

Indexed keywords

INTERLEUKIN 2;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; DNA POLYMORPHISM; EXON; FEMALE; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; ONSET AGE; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CASE-CONTROL STUDIES; EXONS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-2; JAPAN; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS);

EID: 0037116224     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(02)00307-6     Document Type: Article

References (16)

1. Abbas A.K., Murphy K.M., Sher A. Functional diversity of helper T lymphocytes. Nature. 383:1996;787-793.
2. Jensen M.A., Arnason B.G., Toscas A., Noronha A. Global inhibition of IL-2 and IFN-gamma secreting T cells precedes recovery from acute monophasic experimental autoimmune encephalomyelitis. J. Autoimmun. 9:1996;587-597.
3. Kennedy M.K., Torrance D.S., Picha K.S., Mohler K.M. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:1992;2496-2505.
4. Petitto J.M., Streit W.J., Huang Z., Butfiloski E., Schiffenbauer J. Interleukin-2 gene deletion produces a robust reduction in susceptibility to experimental autoimmune encephalomyelitis in C57BL/6 mice. Neurosci. Lett. 285:2000;66-70.
5. Encinas J.A., Wicker L.S., Peterson L.B.et al. QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing IL2. Nat. Genet. 21:1999;158-160.
6. John S., Turner D., Donn R.et al. Two novel biallelic polymorphisms in the IL-2 gene. Eur. J. Immunogenet. 25:1998;419-420.
7. Matesanz F., Delgado C., Fresno M., Alcina A. Allelic selection of human IL-2 gene. Eur. J. Immunol. 30:2000;3516-3521.
8. Hutchinson I.V., Pravica V., Perrey C., Sinnott P. Cytokine gene polymorphisms and relevance to forms of rejection. Transplant. Proc. 31:1999;734-736.
9. Hoffmann S.C., Stanley E.M., Darrin C.E.et al. Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes. Transplantation. 72:2001;1444-1450.
10. Matesanz F., Fedetz M., Collado-Romero M.et al. Allelic expression and interleukin-2 polymorphisms in multiple sclerosis. J. Neuroimmunol. 119:2001;101-105.
11. Niino M., Fukazawa T., Yabe I., Kikuchi S., Sasaki H., Tashiro K. Vitamin D receptor gene polymorphism in multiple sclerosis and the association with HLA class II alleles. J. Neurol. Sci. 177:2000;65-71.
12. Niino M., Kikuchi S., Fukazawa T., Yabe I., Sasaki H., Tashiro K. Genetic polymorphisms of IL-1beta and IL-1 receptor antagonist in association with multiple sclerosis in Japanese patients. J. Neuroimmunol. 118:2001;295-299.
13. McDonald W.I., Compston A., Edan G.et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann. Neurol. 50:2001;121-127.
14. Fukazawa T., Miyasaka K., Tashiro K.et al. MRI findings of multiple sclerosis with acute transverse myelopathy. J. Neurol. Sci. 110:1992;27-31.
15. McDonnell G.V., Kirk C.W., Hawkins S.A., Graham C.A. An evaluation of interleukin genes fails to identify clear susceptibility loci for multiple sclerosis. J. Neurol. Sci. 176:2000;4-12.
16. Feakes R., Sawcer S., Smillie B., Chataway J., Broadley S., Compston A. No evidence for the involvement of interleukin 2 or the immunoglobulin heavy chain gene cluster in determining genetic susceptibility to multiple sclerosis. J. Neurol. Neurosurg. Psychiatry. 68:2000;679.