Disruption of the murine major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics

Cancer Research

Volumn 62, Issue 24, 2002, Pages 7298-7304

  Mossink, Marieke H ^a   Van Zon, Arend ^a   Fränzel Luiten, Erna ^a   Schoester, Martijn ^a   Kickhoefer, Valerie A ^b   Scheffer, George L ^c   Scheper, Rik J ^c   Sonneveld, Pieter ^a   Wiemer, Erik A C ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ANTHRACYCLINE ANTIBIOTIC AGENT; CISPLATIN; CYTARABINE; CYTOSTATIC AGENT; DEXAMETHASONE; DOCETAXEL; DOXORUBICIN; ETOPOSIDE; GEMCITABINE; GLYCOPROTEIN P; IFOSFAMIDE; LUNG RESISTANCE PROTEIN; MELPHALAN; METHOTREXATE; MITOXANTRONE; MULTIDRUG RESISTANCE PROTEIN; RIBONUCLEOPROTEIN; VERLUKAST; VINCRISTINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; DRUG SENSITIVITY; GENE DELETION; GENE DISRUPTION; GENETIC CONSERVATION; KNOCKOUT MOUSE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; STEM CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; BONE MARROW CELLS; CHIMERA; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; STEM CELLS; VAULT RIBONUCLEOPROTEIN PARTICLES;

EID: 0037115661     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Rome, L. H., Kedersha, N. L., and Chugani, D. C. Unlocking vaults: Organelles in search of a function. Trends Cell Biol., 1: 47-50, 1991.
2. Abbondanza, C., Rossi, V., Roscigno, A., Gallo, L., Belsito, A., Piluso, G., Medici, N., Nigro, V., Molinari, A. M., Moncharmont, B., and Puca, G. A. Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell. J. Cell Biol., 141: 1301-1310, 1998.
3. Chugani, D. C., Rome, L. H., and Kedersha, N. L. Evidence that vault ribonucleo-protein particles localize to the nuclear pore complex. J. Cell Sci., 106: 23-29, 1993.
4. Hamill, D. R., and Suprenant, K. A. Characterization of the sea urchin major vault protein: A possible role for vault ribonucleoprotein particles in nucleocytoplasmic transport. Dev. Biol., 190: 117-128, 1997.
5. Herrmann, C., Golkaramnay, E., Inman, E., Rome, L., and Volknandt, W. Recombinant major vault protein is targeted to neuritic tips of PC12 cells. J. Cell Biol., 144: 1163-1172, 1999.
6. Kong, L. B., Siva, A. C., Rome, L. H., and Stewart, P. L. Structure of the vault, a ubiquitous cellular component. Structure Fold Des., 7: 371-379, 1999.
7. Li, J. Y., Volknandt, W., Dahlstrom, A., Herrmann, C., Blasi, J., Das, B., and Zimmermann, H. Axonal transport of ribonucleoprotein particles (vaults). Neuroscience, 91: 1055-1065, 1999.
8. Izquierdo, M. A., Scheffer, G. L., Flens, M. J., Giaccone, G., Broxterman, H. J., Meijer, C. J., van der Valk, P., and Scheper, R. J. Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors. Am. J. Pathol., 148: 877-887, 1996.
9. Schroeijers, A. B., Siva, A. C., Scheffer, G. L., de Jong, M. C., Bolick, S. C., Dukers, D. F., Slootstra, J. W., Meloen, R. H., Wiemer, E., Kickhoefer, V. A., Rome, L. H., and Scheper, R. J. The Mr 193, 000 vault protein is up-regulated in multidrug-resistant cancer cell lines. Cancer Res., 60: 1104-1110, 2000.
10. Scheper, R. J., Broxterman, H. J., Scheffer, G. L., Kaaijk, P., Dalton, W. S., van Heijningen, T. H., van Kalken, C. K., Slovak, M. L., de Vries, E. G., van der Valk, P., and et al. Overexpression of a M(r) 110, 000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance. Cancer Res., 53: 1475-1479, 1993.
11. Kickhoefer, V. A., Rajavel, K. S., Scheffer, G. L., Dalton, W. S., Scheper, R. J., and Rome, L. H. Vaults are up-regulated in multidrug-resistant cancer cell lines. J. Biol. Chem., 273: 8971-8974, 1998.
12. Izquierdo, M. A., Shoemaker, R. H., Flens, M. J., Scheffer, G. L., Wu, L., Prather, T. R., and Scheper, R. J. Overlapping phenotypes of multidrug resistance among panels of human cancer-cell lines. Int. J. Cancer, 65: 230-237, 1996.
13. Scheffer, G. L., Schroeijers, A. B., Izquierdo, M. A., Wiemer, E. A., and Scheper, R. J. Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer. Curr. Opin. Oncol., 12: 550-556, 2000.
14. Kitazono, M., Okumura, H., Ikeda, R., Sumizawa, T., Furukawa, T., Nagayama, S., Seto, K., Aikou, T., and Akiyama, S. Reversal of LRP-associated drug resistance in colon carcinoma SW-620 cells. Int. J. Cancer, 91: 126-131, 2001.
15. Kitazono, M., Sumizawa, T., Takebayashi, Y., Chen, Z. S., Furukawa, T., Nagayama, S., Tani, A., Takao, S., Aikou, T., and Akiyama, S. Multidrug resistance and the lung resistance-related protein in human colon carcinoma SW-620 cells. J. Natl. Cancer Inst., 91: 1647-1653, 1999.
16. Scheffer, G. L., Wijngaard, P. L., Flens, M. J., Izquierdo, M. A., Slovak, M. L., Pinedo, H. M., Meijer, C. J., Clevers, H. C., and Scheper, R. J. The drug resistance-related protein LRP is the human major vault protein. Nat. Med., 1: 578-582, 1995.
17. Siva, A. C., Raval-Fernandes, S., Stephen, A. G., LaFemina, M. J., Scheper, R. J., Kickhoefer, V. A., and Rome, L. H. Up-regulation of vaults may be necessary but not sufficient for multidrug resistance. Int. J. Cancer, 92: 195-202, 2001.
18. Harrington, L, McPhail, T., Mar, V., Zhou, W., Oulton, R., Bass, M. B., Arruda, I., and Robinson, M. O. A mammalian telomerase-associated protein. Science (Wash. DC), 275: 973-977, 1997.
19. Kickhoefer, V. A., Stephen, A. G., Harrington, L., Robinson, M. O., and Rome, L. H. Vaults and telomerase share a common subunit, TEP1. J. Biol. Chem., 274: 32712-32717, 1999.
20. Liu, Y., Snow, B. E., Hande, M. P., Baerlocher, G., Kickhoefer, V. A., Yeung, D., Wakeham, A., Itie, A., Siderovski, D. P., Lansdorp, P. M., Robinson, M. O., and Harrington, L. Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo. Mol. Cell. Biol., 20: 8178-8184, 2000.
21. Kickhoefer, V. A., Liu, Y., Kong, L. B., Snow, B. E., Stewart, P. L., Harrington, L., and Rome, L. H. The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle. J. Cell Biol., 152: 157-164, 2001.
22. Smith, S. The world according to PARP. Trends Biochem. Sci., 26: 174-179, 2001.
23. Kickhoefer, V. A., Siva, A. C., Kedersha, N. L., Inman, E. M., Ruland, C., Streuli, M., and Rome, L. H. The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase. J. Cell Biol., 146: 917-928, 1999.
24. Stephen, A. G., Raval-Fernandes, S., Huynh, T., Torres, M., Kickhoefer, V. A., and Rome, L. H. Assembly of vault-like particles in insect cells expressing only the major vault protein. J. Biol. Chem., 276: 23217-23220, 2001.
25. Mossink, M., van Zon, A., Franzel-Luiten, E., Schoester, M., Scheffer, G., Scheper, R., Sonneveld, P., and Wiemer, E. The genomic sequence of the murine major vault protein and its promoter. Gene, 294: 225-232, 2002.
26. Hogan, B., Beddington, R., Costantini, F., and Lacy, E. Manipulating the Mouse Embryo: A Laboratory Manual, Ed. 2, p. 497. New York: Cold Spring Harbor Laboratory Press, 1994.
27. Sambrook, J., Fritsch, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual, 2nd Edition. Cold Spring Harbor Laboratory Press, NY. 1989.
28. Kedersha, N. L., and Rome, L. H. Isolation and characterization of a novel ribonucleoprotein particle: Large structures contain a single species of small RNA. J. Cell Biol., 103: 699-709, 1986.
29. Allen, J. D., van Loevezijn, A., Lakhai, J. M., Van Der Valk, M., Van Tellingen, O., Reid, G., Schellens, J. H. M., Koomen, G., and Schinkel, A. H. Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse iontestine by a novel analogue of fumitremorgin C. Mol. Cancer Ther., 1: 417-425, 2002.
30. Dalton, W. S., Grogan, T. M., Rybski, J. A., Scheper, R. J., Richter, L., Kailey, J., Broxterman, H. J., Pinedo, H. M., and Salmon, S. E. Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: Association with level of drug resistance and drug accumulation. Blood. 73: 747-752, 1989.
31. Zijlstra, J. G., de Vries, E. G., and Mulder, N. H. Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line. Cancer Res., 47: 1780-1784, 1987.
32. Miyake, K., Mickley, L., Litman, T., Zhan, Z., Robey, R., Cristensen, B., Brangi, M., Greenberger, L., Dean, M., Fojo, T., and Bates, S. E. Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: Demonstration of homology to ABC transport genes. Cancer Res., 59: 8-13, 1999.
33. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65: 55-63, 1983.
34. Schinkel, A. H., Smit, J. J., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol. C. A., van der Valk, M. A., Robanus-Maandag, E. C., te Riele, H. P., and et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell. 77: 491-502, 1994.
35. Lorico, A., Rappa, G., Flavell, R. A., and Sartorelli, A. C. Double knockout of the MRP gene leads to increased drug sensitivity in vitro. Cancer Res., 56: 5351-5355, 1996.
36. Schroeijers, A. B., Reurs, A. W., Scheffer, G. L., Stam, A. G., de Jong, M. C., Rustemeyer, T., Wiemer, E. A., de Gruijl, T. D., and Scheper, R. J. Up-regulation of drug resistance-related vaults during dendritic cell development. J. Immunol., 168: 1572-1578, 2002.