CLINICAL TRIAL;
COMPARATIVE STUDY;
DRUG DESIGN;
DRUG EFFICACY;
DRUG SCREENING;
DRUG TARGETING;
GENETIC POLYMORPHISM;
HIGHLY ACTIVE ANTIRETROVIRAL THERAPY;
HUMAN;
HUMAN IMMUNODEFICIENCY VIRUS INFECTION;
PHARMACOGENOMICS;
POPULATION;
PROTEIN ANALYSIS;
REVIEW;
VIRUS REPLICATION;
ANIMALS;
ANTI-HIV AGENTS;
DRUG DESIGN;
DRUG RESISTANCE, MULTIPLE, VIRAL;
HUMANS;
MODELS, CHEMICAL;
MODELS, MOLECULAR;
PHARMACOGENETICS;
Secondary mutations in the protease region of human immunodeficiency virus and virologic failure in drug-naive patients treated with protease inhibitor-based therapy
Perno C.F., et al. Secondary mutations in the protease region of human immunodeficiency virus and virologic failure in drug-naive patients treated with protease inhibitor-based therapy. J. Infect. Dis. 184:2001;983-991.
Computational study of protein specificity: The molecular basis of HIV-1 protease drug resistance
Wang W., Kollman P.A. Computational study of protein specificity: the molecular basis of HIV-1 protease drug resistance. Proc. Natl. Acad. Sci. U. S. A. 98:2001;14937-14942.
Quantitative prediction of HIV-1 phenotypic drug resistance from genotypes: The virtual phenotype (VirtualPhenotype)
Larder B.A., et al. Quantitative prediction of HIV-1 phenotypic drug resistance from genotypes: the virtual phenotype (VirtualPhenotype). Antivir. Ther. 5:(Suppl. 3):2000;49.
Shenderovich, M. et al. (2002) Structural Phenotype Predicts HIV-1 Protease Inhibitor Resistance. Presented at the 9th Conference on Retroviruses and Opportunistic Infections, 24-28 February 2002.
Structural pharmacogenomic approach to the evaluation of drug resistant mutations in HIV-1 protease
Shenderovich M., et al. Structural pharmacogenomic approach to the evaluation of drug resistant mutations in HIV-1 protease. J. Clin. Ligand Assay. 24:2001;140-144.
Comparative analysis of two commercial phenotypic assays for drug susceptibility testing of human immunodeficiency virus type 1
Qari S.H., et al. Comparative analysis of two commercial phenotypic assays for drug susceptibility testing of human immunodeficiency virus type 1. J. Clin. Microbiol. 40:2002;31-35.
A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1
Petropoulos C.J., et al. A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1. Antimicrob. Agents Chemother. 44:2000;920-928.
Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: Insights into the mechanisms of drug resistance
Hong L., et al. Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: insights into the mechanisms of drug resistance. Protein Sci. 9:2000;1898-1904.