Synthesis and characterization of 6-chloroacetyl-2-dimethylaminonaphthalene as a fluorogenic substrate and a mechanistic probe for glutathione transferases

Analytical Biochemistry

Volumn 311, Issue 2, 2002, Pages 171-178

  Svensson, Richard ^a   Grenö, Caroline ^a   Johansson, Ann Sofie ^b   Mannervik, Bengt ^b   Morgenstern, Ralf ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Environmentally sensitive probe; Fluorogenic substrate; Glutathione transferase

Indexed keywords

BINDING ENERGY; BINDING SITES; BLUE SHIFT; ENZYMES; FLUORESCENCE; PEPTIDES; PROBES; SOLVENTS;

ENVIRONMENTALLY SENSITIVE; ENZYME CATALYZED REACTION; FLUORESCENCE INTENSITIES; FLUOROGENIC SUBSTRATE; GLUTATHIONE TRANSFERASE; INTRINSIC FLUORESCENCE; STOPPED-FLOW MEASUREMENTS; SYNTHESIS AND CHARACTERIZATIONS;

SUBSTRATES;

1 CHLORO 2,4 DINITROBENZENE; 6 CHLOROACETYL 2 DIMETHYLAMINONAPHTHALENE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; MICROSOME ENZYME; NAPHTHALENE DERIVATIVE; UNCLASSIFIED DRUG; 2 NAPHTHYLAMINE; 6 BROMOACETYL 2 DIMETHYLAMINONAPHTHALENE; 6-BROMOACETYL-2-DIMETHYLAMINONAPHTHALENE; 6-CHLOROACETYL-2-DIMETHYLAMINONAPHTHALENE; ACRYLODAN; DRUG DERIVATIVE; FLUORESCENT DYE;

ANALYTIC METHOD; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CYTOSOL; ENZYME ACTIVITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; SENSOR; SYNTHESIS; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET SPECTROPHOTOMETRY; KINETICS; METABOLISM;

2-NAPHTHYLAMINE; FLUORESCENT DYES; GLUTATHIONE TRANSFERASE; HUMANS; KINETICS;

EID: 0037114936     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2697(02)00406-2     Document Type: Article

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