Nifurtimox biotransformation to reactive metabolites or nitrite in liver subcellular fractions and model systems

Toxicology Letters

Volumn 136, Issue 1, 2002, Pages 1-8

  Montalto De Mecca, M ^a   Diaz, E G ^a   Castro, J A ^a  

^a Centro de Investigaciones Toxicologicos   (Argentina)

Author keywords

Liver nuclei or microsomes or mitochondria; Nifurtimox; Nitric oxide and peroxynitrite formation; Nitroreductase activity

Indexed keywords

CARBON MONOXIDE; CYTOCHROME P450 REDUCTASE; FLAVINE ADENINE NUCLEOTIDE; NIFURTIMOX; NITRITE; NITROREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

AIR; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; METABOLITE; MODEL; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION; TOXICITY TESTING;

ANAEROBIOSIS; ANIMALS; BIOTRANSFORMATION; CELL NUCLEUS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LIVER; MALE; MICROSOMES, LIVER; MITOCHONDRIA, LIVER; MODELS, BIOLOGICAL; NADP; NADPH-FERRIHEMOPROTEIN REDUCTASE; NIFURTIMOX; NITRITES; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; SUBCELLULAR FRACTIONS;

EID: 0037111486     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00238-2     Document Type: Article

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