Expression of the HMGA2-LPP fusion transcript in only 1 of 61 karyotypically normal pulmonary chondroid hamartomas

Cancer Genetics and Cytogenetics

Volumn 138, Issue 2, 2002, Pages 160-164

  Lemke, Inga ^a   Rogalla, Piere ^a   Grundmann, Felix ^a   Kunze, Wolf Peter ^b   Haupt, Rolf ^c   Bullerdiek, Jörn ^a  

^a UNIVERSITY OF BREMEN   (Germany)

^b Practice of Pathology ^*  (Germany)

^c Klinikum St Georg   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP A2 PROTEIN; PROTEIN DERIVATIVE; PROTEIN LPP; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; DISEASE COURSE; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC TRANSCRIPTION; HAMARTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; KARYOTYPE; LUNG TUMOR; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 3; CYTOSKELETAL PROTEINS; HAMARTOMA; HMGA2 PROTEIN; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LUNG NEOPLASMS; ONCOGENE PROTEINS, FUSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSLOCATION, GENETIC;

EID: 0037110195     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-4608(02)00595-2     Document Type: Article

References (18)

1. Ashar H.R., Schoenberg Fejzo M., Tkachenko A., Zhou X., Fletcher J.A., Weremowicz S., Morton C.C., Chada K. Disruption of the architectural factor HMGI-C. DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains Cell. 82:1995;57-65.
2. Schoenmakers E.F.P.M., Wanschura S., Mols R., Bullerdiek J., Van den Berghe H., Van de Ven W. Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nat Genet. 10:1995;436-444.
3. Mashal R.D., Fejzo M.L., Friedman A.J., Mitchner N., Nowak R.A., Rein M.S., Morton C.C., Sklar J. Analysis of androgen receptor DNA reveals the independent clonal origins of uterine leiomyomata and the secondary nature of cytogenetic aberrations in the development of leiomyomata. Genes Chromosomes Cancer. 11:1994;1-6.
4. Xing Y.P., Powell W.L., Morton C.C. The del(7q) subgroup in uterine leiomyomata. genetic and biologic characteristics. Further evidence for the secondary nature of cytogenetic abnormalities in the pathobiology of uterine leiomyomata Cancer Genet Cytogenet. 98:1997;69-74.
5. Mark J., Havel G., Grepp C., Dahlenfors R., Wedell B. Chromosomal patterns in human benign uterine leiomyomas. Cancer Genet Cytogenet. 44:1990;1-13.
6. Sreekantaiah C., Leong S.P.L., Karakousis C.P., McGee D.L., Rappaport W.D., Villar H.V., Neal D., Fleming S., Wankel A., Herrington P.N., Carmona R., Sandberg A.A. Cytogenetic profile of 109 lipomas. Cancer Res. 51:1991;422-433.
7. Kazmierczak B., Kayser K., Meyer-Bolte K., Thode E., Bullerdiek J. Results of cytogenetic analyses on 317 pulmonary chondroid hamartomas point to their pathogenesis. Electronic J Pathol. 5.4:1999.
8. Kazmierczak B., Meyer-Bolte K., Tran K.H., Wöckel W., Breightman I., Rosigkeit J., Bartnitzke S., Bullerdiek J. A high frequency of tumors with rearrangements of genes of the HMGI(Y) family in a series of 191 pulmonary chondroid hamartomas. Genes Chromosomes Cancer. 26:1999;125-133.
9. Wanschura S., Belge G., Stenman G., Kools P.F.J., Dal Cin P., Schoenmakers E.F.P.M., Huysmans C., Bartnitzke S., Van de Ven W.J.M., Bullerdiek J. Mapping of the translocation breakpoints of primary pleomorphic adenomas and lipomas within a common region of chromosome 12. Cancer Genet Cytogenet. 86:1996;39-45.
10. Rogalla P., Drechsler K., Frey G., Hennig Y., Helmke B., Bonk U., Bullerdiek J. HMGI-C expression patterns in human tissues - implications for the genesis of frequent mesenchymal tumors. Am J Pathol. 149:1996;775-779.
11. Rogalla P., Rohen C., Hennig Y., Deichert U., Bonk U., Bullerdiek J. Telomere repeat fragment sizes do not limit the growth potential of uterine leiomyomas. Biochem Biophys Res Commun. 211:1995;175-182.
12. Rogalla P., Lemke I., Kazmierczak B., Bullerdiek J. An identical HMGIC-LPP fusion transcript is consistently expressed in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15). Genes Chromosomes Cancer. 29:2000;363-366.
13. Bullerdiek J., Bartnitzke S., Weinberg M., Chilla R., Haubrich J., Schloot W. Rearrangements of chromosome region 12q13-q15 in pleomorphic adenomas of the human salivary gland (PSA). Cytogenet Cell Genet. 45:1987;187-190.
14. Kools P.F., Roebroek A.F., Van de Velde H.J., Marynen P., Bullerdiek J., Van de Ven W.J. Regional mapping of the human NSP gene to chromosome region 14q21→q22 by fluorescence in situ hybridization analysis. Cytogenet Cell Genet. 66:1994;48-50.
15. Schoenmakers E.F., Kools P.F., Mols R., Kazmierczak B., Bartnitzke S., Bullerdiek J., Dal Cin P., De Jong P.J., Van den Berghe H., Van de Ven W.J. Physical mapping of chromosome 12q breakpoints in lipoma, pleomorphic salivary gland adenoma, uterine leiomyoma, and myxoid liposarcoma. Genomics. 20:1994;210-222.
16. Kievits T., Dauwerse J.G., Wiegant J., Devilee P., Breuning M.H., Cornelisse C.J., van Ommen G.J., Pearson P.L. Rapid subchromosomal localization of cosmids by nonradioactive in situ hybridization. Cytogenet Cell Genet. 53:1990;134-136.
17. Lemke I., Rogalla P., Bullerdiek J. Large deletion of part of the HMGA2 locus accompanying a t(3;12)(q27-28;q14-15) in lipoma. Cancer Genet Cytogenet. 129:2001;161-164.
18. Rogalla P., Kazmierczak B., Meyer-Bolte K., Tran K.H., Bullerdiek J. The t(3;12)(q27;q14-15) with underlying HMGIC-LPP fusion is not determining an adipocytic phenotype. Genes Chromosomes Cancer. 22:1998;100-104.