Cell lineage-specific effects associated with multiple deficiencies of tumor susceptibility genes in Msh2-/-Rb+/- mice

Cancer Research

Volumn 62, Issue 18, 2002, Pages 5134-5138

  Nikitin, Alexander Yu ^a   Liu, Chia Yang ^a   Flesken Nikitin, Andrea ^a   Chen, Chi Fen ^a   Chen, Phang Lang ^a   Lee, Wen Hwa ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; RETINOBLASTOMA PROTEIN;

ALLELE; ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL LINEAGE; CELL SPECIFICITY; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE INACTIVATION; GENE MUTATION; GENETIC DISORDER; INTESTINE CANCER; LYMPHOMA; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MOLECULAR INTERACTION; MSH2 GENE; NEUROENDOCRINE TUMOR; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; SKIN CARCINOGENESIS; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; BASE PAIR MISMATCH; CELL LINEAGE; DNA-BINDING PROTEINS; GASTROINTESTINAL NEOPLASMS; GENES, RETINOBLASTOMA; GENES, TUMOR SUPPRESSOR; GENETIC PREDISPOSITION TO DISEASE; HEMATOPOIETIC STEM CELLS; LYMPHOMA; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, KNOCKOUT; MICROSATELLITE REPEATS; MUTS HOMOLOG 2 PROTEIN; NEOPLASMS, EXPERIMENTAL; PROTO-ONCOGENE PROTEINS; SKIN NEOPLASMS;

EID: 0037105719     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. A genetic model for colorectal tumorigenesis
2. The retinoblastoma protein: More than a tumor suppressor
3. RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/-mice
4. Cooperative tumorigenic effects of germline mutations in Rb and p53
5. p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice
6. MutS homologs in mammalian cells
7. Mouse models for colorectal cancer
8. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
9. Inactivation of the mouse Brcal gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development
10. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
11. +/- mice
12. A genetic map of the mouse with 4,006 simple sequence length polymorphisms
13. Retinoblastoma gene deficiency has mitogenic but not tumorigenic effects on erythropoiesis
14. Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
15. MSH2 deficient mice are viable and susceptible to lymphoid turnouts
16. Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences
17. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation
18. Female embryonic lethality in mice nullizygous for both Msh2 and p53
19. Retinoblastoma protein enhances the fidelity of chromosome segregation mediated by hsHeclp
20. Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability
21. Genetic instability in colorectal cancers
22. +/- mice
23. Essential role for oncogenic Ras in tumour maintenance
24. Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion
25. Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen