Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists

Journal of Medicinal Chemistry

Volumn 45, Issue 17, 2002, Pages 3794-3804

  De Lucca, George V ^a   Kim, Ui T ^a   Johnson, Curt ^a   Vargo, Brian J ^a   Welch, Patricia K ^a   Covington, Maryanne ^a   Davies, Paul ^a   Solomon, Kimberly A ^a   Newton, Robert C ^a   Trainor, George L ^a   Decicco, Carl P ^a   Ko, Soo S ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; CALCIUM ION; CARBANILAMIDE DERIVATIVE; CHEMOKINE RECEPTOR CCR3; EOTAXIN; PIPERIDINE DERIVATIVE; RECEPTOR BLOCKING AGENT;

ARTICLE; BINDING AFFINITY; CALCIUM MOBILIZATION; CHEMOTAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; EOSINOPHIL; HUMAN; HUMAN CELL; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-ALLERGIC AGENTS; CALCIUM; CHEMOKINES, CC; CHEMOTAXIS, LEUKOCYTE; CHO CELLS; CRICETINAE; EOSINOPHILS; HUMANS; PIPERIDINES; RECEPTORS, CHEMOKINE; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 0037103267     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0201767     Document Type: Article

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