메뉴 건너뛰기




Volumn 53, Issue 3-4, 1998, Pages 279-285

The exogenous NADH dehydrogenase of heart mitochondria is the key enzyme responsible for selective cardiotoxicity of anthracyclines

Author keywords

[No Author keywords available]

Indexed keywords

BIOCATALYSIS; DOXORUBICIN; DRUG TOXICITY; ELECTRON TRANSFER; ENZYME ACTIVITY; ENZYMIC OXIDATION; LIPOPHILICITY; MITOCHONDRION;

EID: 0032031959     PISSN: 09395075     EISSN: None     Source Type: Journal    
DOI: 10.1515/znc-1998-3-419     Document Type: Article
Times cited : (66)

References (18)
  • 1
    • 0016647722 scopus 로고
    • Adriamycin, a review
    • Carter S. K. (1975), Adriamycin, a review. J. Nat. Cancer Inst. 55, 1256-1274.
    • (1975) J. Nat. Cancer Inst. , vol.55 , pp. 1256-1274
    • Carter, S.K.1
  • 2
    • 0022967083 scopus 로고
    • Redox cycling of anthracyclines by cardiac mitochondria. 1. Anthracycline radical formation by NADH dehydrogenase
    • Davies K. J. A. and Doroshow J. H. (1986), Redox cycling of anthracyclines by cardiac mitochondria. 1. Anthracycline radical formation by NADH dehydrogenase. J. Biol. Chem. 261, 3060-3067.
    • (1986) J. Biol. Chem. , vol.261 , pp. 3060-3067
    • Davies, K.J.A.1    Doroshow, J.H.2
  • 3
    • 0026089235 scopus 로고
    • Inactivation of cytochrome c oxidase activity in mitochondrial membranes during redox cycling of Doxorubicin
    • Demant E. J. F. (1991), Inactivation of cytochrome c oxidase activity in mitochondrial membranes during redox cycling of Doxorubicin. Biochem. Pharmacol. 41, 543-552.
    • (1991) Biochem. Pharmacol. , vol.41 , pp. 543-552
    • Demant, E.J.F.1
  • 4
    • 0023028913 scopus 로고
    • Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical
    • Doroshow J. H. and Davies K. J. A. (1986), Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical. J. Biol. Chem. 261, 3068-3074.
    • (1986) J. Biol. Chem. , vol.261 , pp. 3068-3074
    • Doroshow, J.H.1    Davies, K.J.A.2
  • 5
    • 0016137069 scopus 로고
    • Inhibition of coenzyme Q10-enzymes, succinoxidase and NADH-oxidase by adriamycin and other quinones having antitumor activity
    • Iwamoto Y., Hansen I. L., Porter T. H. and Folkers K. (1974), Inhibition of coenzyme Q10-enzymes, succinoxidase and NADH-oxidase by adriamycin and other quinones having antitumor activity. Biochem. Biophys. Res. Commun. 58, 633-638.
    • (1974) Biochem. Biophys. Res. Commun. , vol.58 , pp. 633-638
    • Iwamoto, Y.1    Hansen, I.L.2    Porter, T.H.3    Folkers, K.4
  • 6
    • 0028231266 scopus 로고
    • Effects of adriamycin on heart mitochondrial function in rested and exercised rats
    • Ji L. L. and Mitchell E. W. (1994), Effects of adriamycin on heart mitochondrial function in rested and exercised rats. Biochem. Pharmacol. 47, 877-885.
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 877-885
    • Ji, L.L.1    Mitchell, E.W.2
  • 7
    • 0025042858 scopus 로고
    • The reductive deglycosylation of adriamycin in aqueous medium: A pulse radiolysis study
    • Lea J. S., Rushton F. A. P., Land E. J. and Swallow A. J. (1990), The reductive deglycosylation of adriamycin in aqueous medium: a pulse radiolysis study. Free Rad. Res. Comms. 8, 241-249.
    • (1990) Free Rad. Res. Comms. , vol.8 , pp. 241-249
    • Lea, J.S.1    Rushton, F.A.P.2    Land, E.J.3    Swallow, A.J.4
  • 9
    • 0022896230 scopus 로고
    • Myocardial contractility and heart pharmacokinetics of adriamycin following a single administration in rat
    • Monti E., Piccinini F., Villani F. and Favalli L. (1986), Myocardial contractility and heart pharmacokinetics of adriamycin following a single administration in rat. Cancer Chemother. Pharmacol. 18, 289-291.
    • (1986) Cancer Chemother. Pharmacol. , vol.18 , pp. 289-291
    • Monti, E.1    Piccinini, F.2    Villani, F.3    Favalli, L.4
  • 10
    • 0023657326 scopus 로고
    • Demonstration of the existence of an organo-specific NADH dehydrogenase in heart mitochondria
    • Nohl H. (1987), Demonstration of the existence of an organo-specific NADH dehydrogenase in heart mitochondria. Eur. J. Biochem. 169, 585-591.
    • (1987) Eur. J. Biochem. , vol.169 , pp. 585-591
    • Nohl, H.1
  • 11
    • 0023918976 scopus 로고
    • Identification of the site of adriamycin-activation in the heart Cell
    • Nohl H. (1988), Identification of the site of adriamycin-activation in the heart Cell. Biochem. Pharmacol. 37, 2633-2637.
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 2633-2637
    • Nohl, H.1
  • 12
    • 0020961074 scopus 로고
    • .-Generation by adriamycin semiquinone and H202; an explanation for the cardiotoxicity of anthracycline antibiotics
    • .-Generation by adriamycin semiquinone and H202; an explanation for the cardiotoxicity of anthracycline antibiotics. Biochem. Biophys. Res. Commun. 114, 197-205.
    • (1983) Biochem. Biophys. Res. Commun. , vol.114 , pp. 197-205
    • Nohl, H.1    Jordan, W.2
  • 13
    • 0343341585 scopus 로고
    • The biochemical role of ubiquinone and ubiquinone-derivatives in the generation of hydroxyl-radicals from hydrogen peroxide
    • (Bors, W.; Saran, M.; Tait, D., ed.). De Gruyter, New York
    • Nohl H. and Jordan W. (1984), The biochemical role of ubiquinone and ubiquinone-derivatives in the generation of hydroxyl-radicals from hydrogen peroxide. In: Oxygen Radicals in chemistry and Biology (Bors, W.; Saran, M.; Tait, D., ed.). De Gruyter, New York, 155-163.
    • (1984) Oxygen Radicals in Chemistry and Biology , pp. 155-163
    • Nohl, H.1    Jordan, W.2
  • 14
    • 0028670459 scopus 로고
    • Interactions of adriamycin aglycones with mitochrondria may mediate adriamycin cardiotoxicity
    • Sokolove P. M. (1994), Interactions of adriamycin aglycones with mitochrondria may mediate adriamycin cardiotoxicity. Int. J. Biochem. 26, 1341-1350.
    • (1994) Int. J. Biochem. , vol.26 , pp. 1341-1350
    • Sokolove, P.M.1
  • 15
    • 0027176769 scopus 로고
    • Interaction of adriamycin aglycones with isolated mitochondria. Effect of selenium deficiency
    • Sokolove P. M., Kester M. B. and Haynes J. (1993), Interaction of adriamycin aglycones with isolated mitochondria. Effect of selenium deficiency J. Biochem. Pharmacol. 46, 691-697.
    • (1993) J. Biochem. Pharmacol. , vol.46 , pp. 691-697
    • Sokolove, P.M.1    Kester, M.B.2    Haynes, J.3
  • 18
    • 0003753074 scopus 로고
    • Role of oxygen activation in adriamycin-mediated DNAa strand scission and the effect of binding on the redox properties of the drug
    • (Bors, W.; Saran, M.; Tait, D. ed.). De Gruyter, New York
    • Youngman R. J., Goetz F. and Elstner E. F. (1984), Role of oxygen activation in adriamycin-mediated DNAa strand scission and the effect of binding on the redox properties of the drug. In: Oxygen Radicals in Chemistry and Biology (Bors, W.; Saran, M.; Tait, D. ed.). De Gruyter, New York, 131-136.
    • (1984) Oxygen Radicals in Chemistry and Biology , pp. 131-136
    • Youngman, R.J.1    Goetz, F.2    Elstner, E.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.