Longitudinal variation in O6-alkylguanine DNA-alkyltransferase activity in the human colon and rectum

British Journal of Cancer

Volumn 87, Issue 2, 2002, Pages 168-170

  Lees, N P ^a,b   Harrison, K L ^a,c   Hill, E ^c   Hall, C N ^b   Margison, G P ^a   Povey, A C ^a,c  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b WYTHENSHAWE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Colon; MGMT

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; ALKYLATING AGENT;

ADULT; AGED; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CLINICAL ARTICLE; COLON CARCINOGENESIS; COLON CARCINOMA; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; RECTUM CARCINOMA; TUMOR LOCALIZATION;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; ALKYLATING AGENTS; CECAL NEOPLASMS; COLON; FEMALE; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; NEOPLASM PROTEINS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; RECTAL NEOPLASMS; RECTUM; SIGMOID NEOPLASMS; VARIATION (GENETICS);

EID: 0037100742     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600455     Document Type: Article

References (8)

1. 6-methylguanine DNA-methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis
2. 6-atkytguanine-DNA alkyltransferase activity in human colon cancer
3. 6-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC→AT transition in the K-ras oncogene
4. DNA repair: Kinetics and thresholds
5. 6-methylguanine, in normal DNA from the cancer prone regions of the large bowel
6. 6-alkylguanine-DNA alkyltransferase activity in normal and tumour tissue from the human colon and rectum
7. 6-alkylguanine-DNA alkyltransferase assay
8. Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon