Low O6-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC→AT transition in the K-ras oncogene

Carcinogenesis

Volumn 18, Issue 7, 1997, Pages 1299-1302

  Jackson, Peta E ^a,c   Hall, C Nick ^b   O'Connor, Peter J ^a   Cooper, Donald P ^a   Margison, Geoffrey P ^a   Povey, Andrew C ^a,d  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b WYTHENSHAWE HOSPITAL   (United Kingdom)

^c INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; ALKYLATING AGENT; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLTRANSFERASE;

ARTICLE; CANCER PREVENTION; COLORECTAL TUMOR; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MUTAGENIC ACTIVITY; ONCOGENE K RAS; PRIORITY JOURNAL; COLON; ENZYMOLOGY; GENETICS; METABOLISM; MUTATION; ONCOGENE RAS; RECTUM;

COLON; COLORECTAL NEOPLASMS; GENES, RAS; HUMANS; METHYLTRANSFERASES; MUTATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; RECTUM;

EID: 0031284676     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.7.1299     Document Type: Article

References (28)

1. Fearon, E.R. (1992) Genetic alterations underlying colorectal tumorigenesis. Cancer Surv., 12, 119-136.
2. Vogelstein, B., Fearon, E.R., Hamilton, S.R., Kern, S.E., Preisinger, A.C., Leppert, M., Nakamura, Y., White, R., Smita, A.M.M. and Bos, J.L. (1988) Genetic alterations during colorectal tumor development. N. Engl. J. Med., 319, 525-532.
3. Hall, C.N., Badawi, A.F., O'Connor, P.J. and Saffhill, R. (1991) The detection of alkylation damage in the DNA of human gastrointestinal tissues. Br. J. Cancer, 64, 59-63.
4. Jacoby, R.F., Lior, X., Teng, B.-B., Davidson, N.O. and Brasitus, T.A. (1991) Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa. J. Clin. Invest., 87, 624-630.
5. 6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res., 50, 6119-6129.
6. Burmer, G.C. and Loeb, L.A. (1989) Mutations in the KRAS 2 oncogene during progressive stages of human colon carcinoma. Proc. Nalt Acad. Sci. USA, 86, 2403-2407.
7. Zaidi, N.H., Pretlow, A.P., O'Riordan, M.A., Dumenco, L.L., Allay, E. and Gerson, S.L. (1995) Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon. Carcinogenesis, 16, 451-456.
8. Jackson, P.E., Hall, C.N., Badawi, A.F., O'Connor, P.J., Cooper, D.P. and Povey, A.C. (1996) The frequency of K-ras mutations and DNA alkylation in colorectal tissue from individuals living in Manchester. Mol. Carcinogenesis, 16, 12-19.
9. 6-alkylguamne-DNA alkyltransferase activity in schistosomiasis-associated human bladder cancer. Eur. J. Cancer, 30A, 1314-1319.
10. Zaidi, N.H., Potten, C.S., Margison, G.P., Cooper, D.P. and O'Connor, P.J. (1993) Tissue and cell specific methylation, repair and synthesis of DNA in the upper gastrointestinal tract of Wistar rats treated with N-methyl-N′-nitro-N-nitrosoguanidine via the drinking water. Carcinogenesis, 14, 1991-2001.
11. Zaidi, N.H., Potten, C.S., Margison, G.P., Cooper, D.P. and O'Connor, P.J. (1993) Tissue and cell specific methylation, repair and synthesis of DNA in the upper gastrointestinal tract of Wistar rats treated with single doses of N-methyl-N′-nitro-N-nitrosoguanidine. Carcinogenesis, 14, 1981-1990.
12. 6-alkylguanine-DNA alkyltransferase activity in human colon cancer. Clin. Cancer Res., 1, 519-525.
13. 6-methyl guanine-DNA methyltransferase and uracil-DNA glycosylase in human organs. Carcinogenesis, 4, 1565-1568.
14. 6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues. Carcinogenesis, 7, 745-749.
15. 6-methylguanine repair in fibroblast cultures from patients with lung cancer. Cancer Res., 49, 5623-5626.
16. 6-alkylguanine-DNA alkyltransferase in response to ionising radiation is p53 gene dose dependent. Oncogene, 12, 693-697.
17. 6-methylguanine-DNA methyltransferase gene in young patients with adult type cancers and functional assay. Carcinogenesis, 16, 2441-2445.
18. 6-alkylguanine-DNA alkyltransferase activity in human lung. Carcinogenesis, 15, 1535-1539.
19. 6-alkylguanine-DNA alkyltransferase mRNA and activity in mouse tissues. Carcinogenesis, 14, 679-683.
20. 6-alkylguanine-DNA alkyltransferase activity of rat hepatoma cells is increased after a single exposure to alkylating agents. Carcinogenesis, 8, 91-95.
21. Cooper, D.P., O'Connor, P.J. and Margison, G.P. (1982) Effect of acute doses of 2-acetylaminofluroene on the capacity of rat liver to repair methylated purines in DNA in vivo and in vitro. Cancer Res., 42, 4203-1209.
22. 6-alkylguanine-DNA alkyltransferase in human peripheral blood mononuclear cells by temozolomide. Br. J. Cancer., 69, 452-456.
23. 6-alkylguanine-DNA alkyltransferase. Prog. Nucleic Acid Res. Mol. Biol., 51, 167-223.
24. 6-benzylguanine increases the sensitivity of human primary bone marrow cells to the cytotoxic effects of temozolomide. Exp. Haematol., 23, 112-116.
25. Karran, P. and Bignami, M. (1994) DNA damage tolerance, mismatch repair and genome instability. Bioessays, 16, 833-839.
26. Liu, B., Nicolaides, N.C., Markowitz, S. et al. (1995) Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nature Genet., 9, 48-55.
27. Busby, W.F., Jr, Shuker, D.E.G., Charnley, G., Newberne, P.M., Tannenbaum, S.R. and Wogan, G.N. (1985) Carcinogenicity in rats of the nitrosated bile acid conjugate N-nitrosoglycholic acid and N-nitrosotaurocholic acid. Cancer Res., 45, 1367-1371.
28. Rowland, I.R., Granli, T., Bockman, O.C., Key, P.E. and Massey, R.C. (1991) Endogenous N-nitrosation in man assessed by measurement of apparent total N-nitroso compounds in faeces. Carcinogenesis, 12, 1395-1401.