Modulation of L-arginine transport and nitric oxide production by gabexate mesylate

Biochemical Pharmacology

Volumn 64, Issue 2, 2002, Pages 277-283

  Leoncini, Giuliana ^a   Pascale, Raffaele ^a   Signorello, Maria Grazia ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

cGMP; Gabexate mesylate; Human platelets; L Arginine uptake; NO formation; NO synthase activity

Indexed keywords

ARGININE; CYCLIC GMP; GABEXATE MESILATE; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; SERINE PROTEINASE INHIBITOR; TRYPSIN INHIBITOR;

AMINO ACID TRANSPORT; ARTICLE; CELL FREE SYSTEM; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PH; PRIORITY JOURNAL; SYNTHESIS; TEMPERATURE; THROMBOCYTE;

ANTICOAGULANTS; ARGININE; BIOLOGICAL TRANSPORT; BLOOD PLATELETS; CELL SURVIVAL; CELL-FREE SYSTEM; CYCLIC GMP; GABEXATE; HUMANS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I;

EID: 0037099304     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01108-5     Document Type: Article

References (39)

1. The L-arginine-nitric oxide pathway
2. NO at work
3. Nitric oxide insufficiency, platelet activation and arterial thrombosis
4. Microvascular oxidative stress preceding leukocyte activation elicited by in vivo nitric oxide suppression
5. Nitric oxide: An endogenous modulator of leukocyte adhesion
6. The effects of exogenous nitric oxide on smooth muscle cell proliferation following porcine carotid angioplasty
7. Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor
8. Nitric oxide-donor compounds inhibit lipoxygenase activity
9. Selective inhibition of the 12-lipoxygenase pathway of arachidonic acid metabolism by L-arginine or sodium nitroprusside in intact human platelets
10. Nitric oxide donors activate the cyclo-oxygenase and peroxidase activities of prostaglandin H synthase
11. Isolation of nitric oxide synthase from human platelets
12. The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide
13. Nitric oxide and peroxynitrite
14. Suppression of arthritis by an inhibitor of nitric oxide synthase
15. Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: Implications for the treatment of multiple sclerosis
16. Paradoxical fate and biological action of peroxynitrite on human platelets
17. Cross-enzyme inhibition by gabexate mesylate: Formulation and reactivity study
18. Inhibitory effect of protease inhibitor on endothelial cell activation
19. Effect of protease inhibitor on ischemia-reperfusion injury to rat liver
20. Inhibitory effect of a synthetic protease inhibitor (gabexate mesylate) on the respiratory burst oxidase in human neutrophils
21. Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor alpha production of monocytes
22. Selective inhibition of human mast cell tryptase by gabexate mesylate, an antiproteinase drug
23. Platelets of patients affected with essential thrombocythemia are abnormal in plasma membrane and adenine nucleotide content
24. 2+ in human platelets
25. Effect of 2-(1-piperazinyl)-4H-pyrido[1,2-a]pyrimidin-4-one (AP155) on human platelets in vitro
26. Cyclooxygenase inhibition decreases nitric oxide synthase activity in human platelets
27. Protein measurements with the Folin phenol reagent
28. L(+)lactate
29. Lactate dehydrogenase
30. Nitric oxide metabolism and breakdown
31. Oxidative metabolism of human platelets
32. Increased hydrogen peroxide formation in platelets of patients affected with essential thrombocythaemia (ET)
33. Hydrogen peroxide formation in platelets of patients with non-insulin-dependent diabetes mellitus
34. Nitric oxide in excitable tissues: Physiological roles and disease
35. Molecular mechanisms and therapeutic strategies related to nitric oxide
36. Blood radicals: Reactive nitrogen species, reactive oxygen species, transition metal ions and the vascular system
37. Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury
38. Effect of gabexate mesylate (FOY), a drug for serine proteinase-mediated diseases, on the nitric oxide pathway