Analysis of IgE antibodies from a patient with atopic dermatitis: Biased V gene usage and evidence for polyreactive IgE heavy chain complementarity-determining region 3

Journal of Immunology

Volumn 168, Issue 12, 2002, Pages 6305-6313

  Edwards, Michael R ^a   Brouwer, Wandy ^a   Choi, Caroline H Y ^a   Ruhno, John ^a   Ward, Robyn L ^a   Collins, Andrew M ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BOVINE SERUM ALBUMIN; CYCLOPEPTIDE; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; OVOMUCOID; TETANUS TOXOID; VON WILLEBRAND FACTOR;

ANTIGEN BINDING; ARTICLE; ATOPIC DERMATITIS; COMBINATORIAL LIBRARY; COMPLEMENTARITY DETERMINING REGION; FEMALE; GENE CONSTRUCT; GENE MUTATION; GENE REARRANGEMENT; GENE SEQUENCE; HUMAN; IMMUNOREACTIVITY; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

EID: 0037097646     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.12.6305     Document Type: Article

References (66)

1. The human IgE network
2. Triggering of histamine release from rat mast cells by divalent antibodies against IgE-receptors
3. Signalling through the high affinity receptor FcεRI
4. Molecular regulation of human IgE synthesis
5. IgE epitopes on the cat (Felis domesticus) major allergen Fel dI: A study with overlapping synthetic peptides
6. Fine specificity of B-cell epitopes on Felis domesticus allergen I (Fel dI): Effect of reduction and alkylation or deglycosylation on Fel dI structure and antibody binding
7. Conformational stability of B-cell epitopes on group I and group II Dermatophagoides spp, allergens: Effect of thermal and chemical denaturation on the binding of murine IgG and human IgE antibodies
8. Epitope mapping of region 11-70 of ovalbumin (Gal dI) using five synthetic peptides
9. Immunogenicity and antigenicity of synthetic peptides derived from the mite allergen
10. Comparison of the allergenicity of ovalbumin and ovalbumin peptide 323-339
11. + cells in the peripheral blood of atopic, nonatopic and bee venom hypersensitive individuals exhibit the phenotype of highly differentiated B cells
12. Epstein-Barr virus induced IgE production in limiting dilution cultures of normal human B cells
13. Structural studies of immunoglobulin E. II. Amino terminal sequence of the heavy chain
14. Molecular cloning and nucleotide sequence of human ε chain cDNA
15. Molecular cloning and nucleotide sequencing of human immunoglobulin ε chain cDNA
16. Molecular mimicry of the unidentified antigen of myeloma IgE·ND
17. Somatic generation of antibody diversity
18. Antigen receptor gene rearrangement
19. Mutational drift and repertoire shift in the maturation of the immune response
20. Anatomy of the antibody molecule
21. Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions
22. H5 gene segments of a patient with asthma: Implications for IgE
23. Analysis of Ig region genes encoding IgE antibodies in splenic B lymphocytes of a patient with asthma
24. H5. and indicates local clonal expansion, somatic hypermutation and isotype switch events
25. Clonally related IgE and IgG4 transcripts in blood lympocytes of patients with asthma reveal differing patterns of somatic hypermutation
26. Molecular analysis of IgE H-chain transcripts expressed in vivo by peripheral blood lymphocytes from normal and atopic individuals
27. H5 transcripts from three unrelated patients with atopic dermatitis
28. H genes expressed in peripheral blood IgE-producing B cells from patients with atopic dermatitis
29. Immunogenetic analysis of the heavy chain variable regions of IgE from patients allergic to peanuts
30. Construction of a combinatorial IgE library from an allergic patient
31. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction
32. Phage antibodies: Filamentous phage displaying antibody variable domains
33. Generation of diverse high affinity human monoclonal antibodies by repertoire cloning
34. Generation of a large combinatorial library of the immunoglobulin repertoire in phage λ
35. Multi-subunit proteins on the surface of filamentous phage: Methodologies for displaying antibody (Fab) heavy and light chains
36. Assembly of combinatorial antibody libraries on phage surfaces: The gene III site
37. By-passing immunization: Human antibodies from V-gene libraries displayed on phage
38. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
39. Retrieval of human antibodies from phage display libraries using enzymatic cleavage
40. Evaluation of different lymphoid tissue sources for the construction of human immunoglobulin gene libraries
41. H repertoire
42. Nomenclature of the human immunoglobulin heavy (IGH) genes
43. H segments
44. H3-encoded antibody is dependent on the heavy chain CDR3 region and is independent of protein A binding
45. Ig λ and heavy chain gene usage in early untreated systemic lupus erythematosus suggests intensive B cell stimulation
46. The importance of the light chain for the epitope specificity of human anti-Ul small nuclear RNA autoantibodies present in systemic lupus erythematosus patients
47. Molecular analysis of polyreactive monoclonal antibodies from rheumatic carditis: Human anti-N-acetylglucosamine/anti-myosin antibody V region genes
48. Analysis of the molecular basis of synovial rheumatoid factors in rheumatoid arthritis
49. H1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features
50. H6 gene family in patients with autoimmune idiopathic thrombocytopenic purpura
51. H locus completed by analysis of the telomeric region of chromosome 14q
52. Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life
53. Early restriction of the human antibody repertoire
54. H gene families
55. H6 encoded IgM receptors
56. H3 genes and short diverse complementarity-determining regions (CDR3) in human fetal B lymphocyte immunoglobulin heavy chain rearrangements
57. Analysis of Ig H chain gene segment utilization in human fetal liver: Revisiting the "proximal utilization" hypothesis
58. Sequence of the human immunoglobulin diversity (D) segment locus: A systemic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination
59. Natural auto- and polyreactive antibodies differing from antigen-induced antibodies in the H chain CDR3
60. Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments
61. Molecular determinants of polyreactive antibody binding: HCDR3 and cyclic peptides
62. Heavy chain variable region, light chain variable region, and heavy chain CDR3 influences on the mono- and polyreactivity and on the affinity of human monoclonal rheumatoid factors
63. Evidence for somatic selection of natural autoantibodies
64. Determinants of polyreactivity in a large panel of recombinant human antibodies from HIV-I infection
65. Rat basophil leukemia (RBL) cells sensitized with low affinity IgE respond to high valency antigen
66. Antigen valency as a determinant of the responsiveness of IgE-sensitized rat basophil leukemia (RBL) cells