Desensitization of endothelial nitric oxide synthase by receptor agonists

Biochemical Journal

Volumn 364, Issue 3, 2002, Pages 863-868

  Wagner, Sabine ^a   Groschner, Klaus ^a   Mayer, Bernd ^a   Schmidt, Kurt ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

ATP; Bradykinin; Ca2+

Indexed keywords

ADENOSINETRIPHOSPHATE; CALCIUM; CELLS; POSITIVE IONS;

INCUBATION;

ENZYME KINETICS;

ADENOSINE TRIPHOSPHATE; BRADYKININ; CALCIUM ION; CALCIUM IONOPHORE; CITRULLINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; THAPSIGARGIN;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CONTROLLED STUDY; ENDOTHELIUM; ENZYME ACTIVATION; ENZYME INACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SWINE;

ANIMALS; AORTA; BRADYKININ; CALCIUM; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; SWINE; THAPSIGARGIN;

SUIDAE; SUS SCROFA;

EID: 0037096986     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20011178     Document Type: Article

References (33)

1. Signal transduction of eNOS activation
2. 3 receptor and links the internal calcium storage department to plasma membrane CCE channels
3. Recent developments in non-excitable cell calcium entry
4. Biosynthesis and action of nitric oxide in mammalian cells
5. 2+/calmodulin-dependent endothelial nitric oxide synthase activity
6. Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation
7. Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: Implications for nitric oxide signaling
8. Acylation targets endothelial nitric-oxide synthase to plasmaremmal caveolae
9. Endotherial nitric oxide synthase targeting to caveolae-specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells
10. 2+-calmodulin and caveolin
11. Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity
12. Dissecting the interaction between nitric oxide synthase (NOS) and caveorin. Functional significance of the NOS caveolin binding domain in vivo
13. Interaction between caveolin-1 and the reductase domain of endothelial nitric-oxide synthase. Consequences for catalysis
14. The endothelial nitric-oxide synthase-caveolin reguratory cycle
15. Dynamic regulation of endothelial nitric oxide synthase: Complementary roles of dual acylation and caveolin interactions
16. Inhibitory interactions of the bradykinin B2 receptor with endothelial nitric-oxide synthase
17. Endothelial nitric oxide synthase interactions with G-protein-coupled receptors
18. Calcium signal transduction from caveolae
19. Receptor-regulated translocation of endothelial nitric-oxide synthase
20. Nitric oxide attenuates signal transduction. Possible role in dissociating caveolin-1 scaffold
21. Effect of calcium on endothelium-derived relaxing factor formation and cGMP levels in endothelial cells
22. 2+-dependent activation of endothelial nitric-oxide synthase
23. 2+ indicators with greatly improved fluorescence properties
24. Assay of tissue activity of nitric oxide synthase
25. Intracellular alkalinization induced by bradykinin sustains activation of the constitutive nitric oxide synthase in endothelial cells
26. Regulation of cyclic AMP by extracellurar ATP in cultured brain capillary endothelial cells
27. Calcium signalling through nucleotide receptor P2Y2 in cultured human vascurar endothelium
28. Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: Implications for caveolae localization
29. Oxidized low density lipoprotein displaces endothelial nitric-oxide synthase (eNOS) from plasmalemmal caveolae and impairs eNOS activation
30. High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae
31. Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthase
32. Biosynthesis and palmitoylation of endothelial nitric oxide synthase: Mutagenesis of palmitoylation sites, cysteines-15 and/or -26, argues against depalmitoylation-induced translocation of the enzyme
33. Caveolin-1 detergent solubility and association with endothelial nitric oxide synthase is modulated by tyrosine phosphorylation