t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes: Characterization of a new subset of T acute lymphoblastic leukaemia

British Journal of Haematology

Volumn 109, Issue 4, 2000, Pages 788-793

  Mecucci, Cristina ^a   La Starza, Roberta ^a   Negrini, Massimo ^b   Sabbioni, Silvia ^b   Crescenzi, Barbara ^a   Leoni, Pietro ^c   Di Raimondo, Francesco ^d   Krampera, Mauro ^e   Cimino, Giuseppe ^f   Tafuri, Agostino ^f   Cuneo, Antonio ^b   Vitale, Antonella ^f   Foà, Robin ^f  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^d UNIVERSITY OF CATANIA   (Italy)

^e UNIVERSITY OF VERONA   (Italy)

^f SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

NUP98 RAP1GDS1; t(4; 11)(q21:p15); T ALL

Indexed keywords

ASPARAGINASE; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; ETOPOSIDE; PREDNISONE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; CANCER CLASSIFICATION; CASE REPORT; CHROMOSOME TRANSLOCATION 21; CHROMOSOME TRANSLOCATION 4; CLINICAL FEATURE; CYTOGENETICS; DISEASE COURSE; FEMALE; GENE FUSION; GENE REARRANGEMENT; HUMAN; IMMUNOPHENOTYPING; MOLECULAR GENETICS; PRIORITY JOURNAL; RECIPROCAL CHROMOSOME TRANSLOCATION; T CELL LEUKEMIA;

ADOLESCENT; ADULT; AMINO ACID SEQUENCE; ARTIFICIAL GENE FUSION; BASE SEQUENCE; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 4; CHROMOSOMES, HUMAN, PAIR 8; FEMALE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; IN SITU NICK-END LABELING; KARYOTYPING; LEUKEMIA, T-CELL, ACUTE; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; NUCLEAR PORE COMPLEX PROTEINS; NUCLEAR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSLOCATION, GENETIC; TRISOMY;

EID: 0033854646     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.02106.x     Document Type: Article

References (20)

1. Arai, Y, Hosoda, F., Kobayashi, H., Arai, K., Hayashi, Y., Kamada, N., Kaneko, Y. & Ohki, M. (1997) The inv (11) (p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10. Blood, 89, 3936-3944.
2. Berger, R. (1998) Cytogenetics in adult acute lymphoblastic leukemia. Reviews in Clinical and Experimental Hematology, 5, 68-84.
3. Borrow, J., Shearman, A.M., Stanton, Jr, V.P., Becher, R., Collins, T., Williams, A.J., Dube, I., Katz, F., Kwong, Y.L., Morris, C., Ohyashiki, K., Toyama, K., Rowley, J. & Housman, D.E. (1996) The t (7;11) (p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. Nature Genetics, 12, 159-167.
4. Cimino, G., Lo Coco, F., Biondi, A., Elia, L., Luciano, A., Croce, C.M., Masera, G., Mandelli, F. & Canaani, E. (1993) ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy. Blood, 82, 544-546.
5. Fizzotti, M., Cimino, G., Pisegna, S., Alimena, G., Quartarone, C., Mandelli, F., Pelicci, P.G. & Lo Coco, F. (1995) Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia with adverse prognostic factors. Blood, 85, 2685-2690.
6. Hardingham, J.E., Peters, G.B., Dobrovic, A., Dale, B.M., Kotasek, D., Ford, H.E., Story, C.J. & Sage, R.E. (1991) A rare translocation (4;11) (q21;p14-15) in an acute lymphoblastic leukemia expressing T-cell and myeloid markers. Cancer Genetics and Cytogenetics, 56, 255-262.
7. Hussey, D.J., Nicola, M., Moore, S., Peters, G.B. & Dobrovic, A. (1999) The (4;11) (q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia. Blood, 94, 2072-2079.
8. Inoue, S., Tyrkus, M., Ravindranath, Y. & Gohle, N. (1985) A variant translocation between chromosomes 4 and 11, t(4q,11p) in a child with acute leukemia. American Journal of Pediatric Hematology and Oncology, 7, 211-214.
9. ISCN (1995) An International System for Human Cytogenetic Nomenclature (ed. by F. Mitelman). S. Karger, Basel.
10. Kasper, L.H., Brindle, P.K., Schnabel, C.A., Pritchard, C.E., Cleary, M.L. & van Deursen, J.M. (1999) CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity. Molecular and Cellular Biology, 19, 764-776.
11. Nakamura, T., Largaespada, D.A., Lee, M.P., Johnson, L.A., Ohyashiki, K., Toyama, K., Chen, S.J., Willman, C.L., Chen, I.M., Feinberg, A.P., Jenkins, N.A., Copeland, N.G. & Shaughnessy, Jr, J.D. (1996) Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t (7;11) (p15;p15) in human myeloid leukaemia. Nature Genetics, 12, 154-158.
12. Nakamura, T., Yamazaki, Y., Hatano, Y. & Miura, I. (1999) NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1,11) (q23;p15). Blood, 94, 741-747.
13. Negrini, M., Sabbioni, S., Ohta, M., Veronese, M.L., Rattan, S., Junien, C. & Croce, C.M. (1995) Seven megabase yeast artificial chromosome contig at region 11p15: identification of a yeast artificial chromosome spanning the breakpoint of a chromosomal translocation found in a case of Beckwith-Wiedemann syndrome. Cancer Research, 55, 2904-2909.
14. Rapanotti, M.C., Arcese, W., Buffolino, S., Iori, A.P., Mengarelli, A., De Cuia, M.R., Cardillo, A. & Cimino, G. (1997) Sequential molecular cloning of chimerism in chronic myeloid leukemia patients receiving donor lymphocyte transfusion for relapse after bone marrow transplantation. Bone Marrow Transplantation, 19, 703-707.
15. Raza-Egilmez, S.Z., Jani-Sait, S.N., Grossi, M., Higgins, M.J., Shows, T.B. & Aplan, P.D. (1998) NUP98-HOXD13 gene fusion in therapy-related acute myelogenous leukemia. Cancer Research, 58, 4269-4273.
16. Secker-Walker, L.M., Stewart, E.L., Chan, L., O'Callaghan, U. & Chessels, J.M. (1985) The (4;11) translocation in acute leukaemia of childhood: the importance of additional chromosomal aberrations. British Journal of Haematology, 61, 101-111.
17. Shizuya, H., Birren, B., Kim, U.-J., Mancino, V., Slepak, T., Tachiiri, Y. & Simon, M. (1992) Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector. Proceedings of National Academies of Sciences of the United States of America, 89, 8794-8797.
18. Tafuri, A., De Felice, L., Petrucci, M.T., Mascolo, M.G., Ricciardi, M.R., Ciliberti, C., Martelli, M.P. & Petti, M.C. (1995) Multidrug resistance expression and proliferative studies in poor risk acute myeloid leukemia patients treated with the FLAG (G-CASF plus Fludarabine and Ara-c) regimen. Cytokines and Molecular Therapy, 1, 301-307.
19. Von Lindern, M., Fornerod, M., van Baal, S., Jaegle, M., de Wit, T., Buijs, A. & Grosveld, G. (1992a) The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. Molecular and Cellular Biology, 12, 1687-1697.
20. Von Lindern, M., van Baal, S., Wiegant, J., Raap, A., Hagemeijer, A. & Grosveld, G. (1992b) Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3′ half to different genes: characterization of the set gene. Molecular and Cellular Biology, 12, 3346-3355.