In vivo and in vitro myocardial binding of risperidone and 9-hydroxyrisperidone

Toxicology and Applied Pharmacology

Volumn 180, Issue 2, 2002, Pages 145-149

  Titier, Karine ^a   Déridet, Evelyne ^a   Moore, Nicholas ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

9 hydroxyrisperidone; Antipsychotics; Guinea pig; Heart to plasma level ratio; Risperidone; Tissue distribution

Indexed keywords

NEUROLEPTIC AGENT; PALIPERIDONE; RISPERIDONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; DRUG BINDING; DRUG BLOOD LEVEL; DRUG TISSUE LEVEL; ELECTROPHYSIOLOGY; EQUILIBRIUM DIALYSIS; GUINEA PIG; HEART MUSCLE; HEART VENTRICLE ARRHYTHMIA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; ISOLATED HEART; NONHUMAN; PLASMA PROTEIN BINDING; PURKINJE CELL; QT INTERVAL; TISSUE DISTRIBUTION;

CAVIA PORCELLUS; FELIDAE; SUS SCROFA;

EID: 0037091171     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2002.9383     Document Type: Article

References (19)

1. In vitro electrophysiological detection of iatrogenic arrhytmogenicity
2. Distribution after repeated administration of different dose levels of risperidone and 9-hydroxyrisperidone in the brain and other tissues of rat
3. Therapeutic drug monitoring of risperidone using a new rapid HPLC method: Reappraisal of interindividual variability factors
4. Atypical antipsychotics. Part II: Adverse effects, drug interactions, and costs
5. Antipsychotic drug and heart muscle disorder in international pharmacovigilance: Data mining study
6. Prolongation of QT interval in isolated feline hearts by antipsychotic drugs
7. Antipsychotic drugs: Prolonged QTc interval, torsade de pointes, and sudden death
8. Long term treatment with antipsychotic drugs in conventional doses prolonged QTc dispersion, but did not increase ventricular tachyarrythmias in patients with schizophrenia in the absence of cardiac disease
9. A case of risperidone overdose in early schizophrenia: A review of potential complications
10. Acute poisoning by risperidone and ionic and electrocardiographic changes
11. In vitro and in vivo evaluation of the tissue to blood partition coefficient for physiological pharmacokinetic models
12. Atypical antipsychotics. Part I: Pharmacology, pharmacokinetics, and efficacy
13. The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium chanel HERG
14. Fatal cardiac event following initiation of risperidone therapy
15. QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients
16. Receptor pharmacology of neuroleptics: Relation to clinical effects
17. The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes
18. Simplified high-performance liquid chromatographic method for determination of risperidone and 9-hydroxyrisperidone in plasma and tissue
19. Effect of risperidone on QT interval and QT dispersion in the elderly