The importin-β P446L dominant-negative mutant protein loses RanGTP binding ability and blocks the formation of intact nuclear envelope

Journal of Cell Science

Volumn 115, Issue 8, 2002, Pages 1675-1687

  Timinszky, Gyula ^a   Tirián, László ^a   Nagy, Ferenc T ^a   Tóth, Gábor ^a   Perczel, András ^a   Kiss László, Zsuzsanna ^a   Boros, Imre ^a   Clarke, Paul R ^a   Szabad, János ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Dominant negative mutations; Drosophila; Importin ; Nuclear envelope formation; Ran

Indexed keywords

CYTOSINE; GUANOSINE TRIPHOSPHATE; KARYOPHERIN; LEUCINE; MUTANT PROTEIN; NUCLEAR PROTEIN; PEPTIDE; PROLINE; RAN PROTEIN; THYMINE; DROSOPHILA PROTEIN; FLUORESCENT DYE; FS(2)KET PROTEIN, DROSOPHILA; HYBRID PROTEIN; KARYOPHERIN BETA; LAMIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CELL NUCLEUS MEMBRANE; CHROMOSOME SEGREGATION; CIRCULAR DICHROISM; CONTROLLED STUDY; DROSOPHILA; GENE IDENTIFICATION; GENE MUTATION; INTERPHASE; MEMBRANE FORMATION; MITOSIS; MITOSIS SPINDLE; NONHUMAN; NUCLEAR IMPORT; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; ACTIVE TRANSPORT; AMINO ACID SEQUENCE; ANIMAL; CELL CYCLE; CHEMICAL STRUCTURE; CHEMISTRY; CHROMATIN; DROSOPHILA MELANOGASTER; FEMALE; FEMALE INFERTILITY; GENETICS; HELA CELL; HISTOLOGY; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; PHYSIOLOGY; PRENATAL DEVELOPMENT; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; TRANSGENE;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; ANIMAL; BETA KARYOPHERINS; CELL CYCLE; CHROMATIN; CIRCULAR DICHROISM; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; FLUORESCENT DYES; HELA CELLS; HUMAN; INFERTILITY, FEMALE; LAMINS; MITOTIC SPINDLE APPARATUS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR ENVELOPE; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RAN GTP-BINDING PROTEIN; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SUPPORT, NON-U.S. GOV'T; TRANSGENES; ANIMALS; HUMANS;

EID: 0037089085     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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