Insulin, but not proinsulin C-peptide, enhances platelet fibrinogen binding in vitro in Type 1 diabetes mellitus patients and healthy subjects

Thrombosis Research

Volumn 106, Issue 2, 2002, Pages 91-95

  Hu, Hu ^a   Li, Nailin ^a   Ekberg, Karin ^a   Johansson, Bo Lennart ^a   Hjemdahl, Paul ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Diabetes mellitus; Flow cytometry; Insulin; Platelets; Proinsulin C peptide

Indexed keywords

ADENOSINE DIPHOSPHATE; C PEPTIDE; FIBRINOGEN; INSULIN; PADGEM PROTEIN;

ADULT; ARTICLE; BINDING ASSAY; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; THROMBOCYTE ACTIVATION;

ADENOSINE DIPHOSPHATE; ADULT; BLOOD PLATELETS; C-PEPTIDE; DIABETES MELLITUS, TYPE 1; FIBRINOGEN; HUMANS; INSULIN; MALE; MIDDLE AGED; P-SELECTIN; PEPTIDES; PLATELET ACTIVATION; PROTEIN BINDING; RECEPTORS, FIBRINOGEN; STIMULATION, CHEMICAL;

EID: 0037089057     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(02)00054-3     Document Type: Article

References (27)

1. + transport in diabetes mellitus. Diabetes. 39:1990;850-854.
2. Winocour P.D. Platelets, vascular disease, and diabetes mellitus. Can J Physiol Pharmacol. 72:1994;295-303.
3. Tschoepe D., Roesen P., Esser J., Schwippert B., Nieuwenhuis H.K., Kehrel B., Gries F.A. Large platelets circulate in an activated state in diabetes mellitus. Semin Thromb Hemost. 17:1991;433-438.
4. Crofford O.B. Diabetes control and complications. Annu Rev Med. 46:1995;267-279.
5. Trovati M., Anfossi G., Cavalot F., Massucco P., Mularoni E., Emanuelli G. Insulin directly reduces platelet sensitivity to aggregating agents. Studies in vitro and in vivo. Diabetes. 37:1988;780-786.
6. Kahn N.N., Bauman W.A., Hatcher V.B., Sinha A.K. Inhibition of platelet aggregation and the stimulation of prostacyclin synthesis by insulin in humans. Am J Physiol. 265:1993;H2160-H2167.
7. Murer E.H., Gyda M.A., Martinez N.J. Insulin increases the aggregation response of human platelets to ADP. Thromb Res. 73:1994;69-74.
8. Yngen M., Li N., Hjemdahl P., Wallen N.H. Insulin enhances platelet activation in vitro. Thromb Res. 104:2001;85-91.
9. Lopez-Aparicio P., Rascon A., Manganiello V.C., Andersson K.E., Belfrage P., Degerman E. Insulin induced phosphorylation and activation of the cGMP-inhibited cAMP phosphodiesterase in human platelets. Biochem Biophys Res Commun. 186:1992;517-523.
10. Lopez-Aparicio P., Belfrage P., Manganiello V.C., Kono T., Degerman E. Stimulation by insulin of a serine kinase in human platelets that phosphorylates and activates the cGMP-inhibited cAMP phosphodiesterase. Biochem Biophys Res Commun. 193:1993;1137-1144.
11. Anfossi G., Massucco P., Mattiello L., Piretto V., Mularoni E., Cavalot F., Paoletti G., Trovati M. Insulin exerts opposite effects on platelet function at physiological and supraphysiological concentrations. Thromb Res. 82:1996;57-68.
12. Steiner D.F. On the role of the proinsulin C-peptide. Diabetes. 27:1978;145-148.
13. Wahren J., Ekberg K., Johansson J., Henriksson M., Pramanik A., Johansson B.L., Rigler R., Jornvall H. Role of C-peptide in human physiology. Am J Physiol. 278:2000;E759-E768.
14. (+)-ATPase activity in synergism with neuropeptide Y. Diabetologia. 39:1996;199-205.
15. +-ATPase activity of renal tubule segments. Diabetologia. 41:1998;287-291.
16. +-ATPase activity in diabetes mellitus type I. Clin Sci. 98:2000;283-290.
17. Johansson B.L., Borg K., Fernqvist-Forbes E., Odergren T., Remahl S., Wahren J. C-peptide improves autonomic nerve function in IDDM patients. Diabetologia. 39:1996;687-695.
18. Johansson B-L, Borg K., Fernqvist-Forbes E., Kernell A., Odergeren T., Wahren J. Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with type I diabetes - a three-month study. Diabet Med. 17:2000;181-189.
19. Janes S.L., Wilson D.J., Chronos N., Goodall A.H. Evaluation of whole blood flow cytometric detection of platelet bound fibrinogen on normal subjects and patients with activated platelets. Thromb Haemost. 70:1993;659-666.
20. Chronos N.A., Wilson D.J., Janes S.L., Hutton R.A., Buller N.P., Goodall A.H. Aspirin does not affect the flow cytometric detection of fibrinogen binding to, or release of alpha-granules or lysosomes from, human platelets. Clin Sci. 87:1994;575-580.
21. Trovati M., Anfossi G., Massucco P., Mattiello L., Costamagna C., Piretto V., Mularoni E., Cavalot F., Bosia A., Ghigo D. Insulin stimulates nitric oxide synthesis in human platelets and, through nitric oxide, increases platelet concentrations of both guanosine-3′,5′-cyclic monophosphate and adenosine-3′,5′-cyclic monophosphate. Diabetes. 46:1997;742-749.
22. Kahn N.N., Sinha A.K. Stimulation of prostaglandin E1 binding to human blood platelet membrane by insulin and the activation of adenylate cyclase. J Biol Chem. 265:1990;4976-4981.
23. Degerman E., Smith C.J., Tornqvist H., Vasta V., Belfrage P., Manganiello V.C. Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation. Proc Natl Acad Sci USA. 87:1990;533-537.
24. Mayfield R.K., Halushka P.V., Wohltmann H.J., Lopes-Virella M., Chambers J.K., Loadholt C.B., Colwell J.A. Platelet function during continuous insulin infusion treatment in insulin-dependent diabetic patients. Diabetes. 34:1985;1127-1133.
25. Yngen M., Ostenson C.G., Li N., Hjemdahl P., Wallen N.H. Acute hyperglycemia increases soluble P-selectin in male patients with mild diabetes mellitus. Blood Coagul Fibrinolysis. 12:2001;109-116.
26. Sly M.K., Eberhart R.C., Prager M.D. Anti-platelet action of nitric oxide and selective phosphodiesterase inhibitors. Shock. 8:1997;115-118.
27. Samama C.M., Diaby M., Fellahi J.L., Mdhafar A., Eyraud D., Arock M., Guillosson J.J., Coriat P., Rouby J.J. Inhibition of platelet aggregation by inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology. 83:1995;56-65.