Adoptive transfer of immature dendritic cells with autologous or allogeneic tumor cells generates systemic antitumor immunity

Cancer Research

Volumn 59, Issue 12, 1999, Pages 2802-2805

  Melcher, Alan ^a,b   Todryk, Stephen ^b   Bateman, Andrew ^a   Chong, Heung ^a   Lemoine, Nicholas R ^b   Vile, Richard G ^a,b  

^a MAYO CLINIC   (United States)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANTIGEN PRESENTATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; COLORECTAL CANCER; DENDRITIC CELL; IMMUNE RESPONSE; IMMUNOGENICITY; MELANOMA; NONHUMAN; PRIORITY JOURNAL; TUMOR IMMUNITY;

ANIMALS; CANCER VACCINES; CELLS, CULTURED; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; IMMUNITY; IMMUNOTHERAPY; IMMUNOTHERAPY, ADOPTIVE; ISOANTIGENS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NEOPLASM TRANSPLANTATION; TRANSPLANTATION, AUTOLOGOUS;

EID: 0033564483     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Steinman, R. M. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol., 9: 271-296, 1991.
2. Banchereau, J., and Steinman, R. M. Dendritic cells and the control of immunity. Nature (Lond.), 392: 245-252, 1998.
3. Mayordormo, J. I., Zorina, T., Storkus, W. J., Zitvogel, L., Celluzzi, C., Falo, L. D., Melief, C. J., Ildstad, S. T., Kast, W. M., DeLeo, A. B., and Lotze, M. T. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nat. Med., 1: 1297-1302, 1995.
4. Porgador, A., and Gilboa, E. Bone marrow-generated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes. J. Exp. Med., 182: 255-260, 1995.
5. Zitvogel, L., Mayordormo, J. I., Tjandrawan, T., DeLeo, A. B., Clarke, M. R., Lotze, M. T., and Storkus, W. J. Therapy of murine tumours with tumour peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines. J. Exp. Med., 183: 87-97, 1996.
6. Cella, M., Sallusto, F., and Lanzavecchia, A. Origin, maturation and antigen presenting function of dendritic cells. Curr. Opin. Immunol., 9: 10-16, 1997.
7. Labeur, M. S., Roters, B., Pers, B., Mehling, A., Lurger, T. A., Schwarz, T., and Grabbe, S. Generation of tumor immunity by bone marrow-derived dendritic cells correlates with dendritic cell maturation stage., J. Immunol., 162: 168-175, 1999.
8. Inaba, K., Inaba, M., Naito, M., and Steinman, R. M. Dendritic cell progenitors phagocytose particulates, including Bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J. Exp. Med., 178: 479-488, 1993.
9. De Smedt, T., Pajak, B., Muraille, E., Lespagnard, L., Heinen, E., De Baetselier, P., Urbain, J., Leo, O., and Moser, M. Regulation of dendritic cells numbers and maturation by lipopolysaccharide in vivo. J. Exp. Med., 184: 1413-1424, 1996.
10. Vile, R. G., Arly Nelson, J., Castleden, S., Chong, H., and Hart, I. R. Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component. Cancer Res., 54: 6228-6234, 1994.
11. Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S., and Steinman, R. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med., 176: 1693-1702, 1992.
12. Morton, D. L., Foshag, L. J., Hoon, D. S. B., Nizze, J. A., Wanek, L. A., Chang, C., Davtyan, D. G., Gupta, R. K., Elashoff, R., and Irie, R. F. Prolongation of survival in metastatic melanoma after active specific immunotherapy with a new polyvalent melanoma vaccine. Ann. Surg., 216: 463-482, 1992.
13. Plautz, G. E., Yang, Z., Wu, B., Gao, X., Huang, L., and Nabel, G. J. Immunotherapy of malignancy by in vivo gene transfer into tumors. Proc. Natl. Acad. Sci. USA, 90: 4645-4649, 1993.
14. Dranoff, D., Jaffee, E., Lazenby, A., Golumbek, P., Levitsky, H., Brose, K., Jackson, V., Hamada, H., Pardoll, D., and Mulligan, R. C. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl. Acad. Sci. USA, 90: 3539-3543, 1993.
15. Caruso, M., Pham-Nguyen, K., Kwong, Y-L. Xu, B., Kosai, K-I., Finegold, M., Woo, S. L. C., and Chen, S-H. Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma. Proc. Natl. Acad. Sci. USA, 93: 11302-11306, 1996.
16. Tuting, T., Wilson, C. C., Martin, D. M., Kasamon, Y. L., Rowles, J., Ma, D. I., Slingluff, C. L., Wagner, S. N., van der Bruggen, P., Baar, J., Lotze, M. T., and Storkus, W. J. Autologous human monocyte-derived dendritic cells genetically modified to express melanoma antigens elicit primary cytotoxic T cell responses in vitro: enhancement by cotransfection of genes encoding the Th1-biasing cytokines IL-12 and IFN-α. J. Immunol., 160: 1139-1147, 1998.
17. Thomas, M. C., Greten, T. F., Pardoll, D. M., and Jaffee, E. M. Enhanced tumour protection by granulocyte-macrophage colony-stimulating factor expression at the site of an allogeneic vaccine. Hum. Gene Ther., 9: 835-843, 1998.