Association of NAT1 and NAT2 polymorphisms to urinary bladder cancer: Significantly reduced risk in subjects with NAT1*10

Cancer Research

Volumn 61, Issue 13, 2001, Pages 5051-5056

  Cascorbi, Ingolf ^a,b   Roots, Ivar ^a   Brockmöller, Jürgen ^a,c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLAMINE ACETYLTRANSFERASE;

ADULT; AGED; ARTICLE; BLADDER CANCER; BLADDER CARCINOGENESIS; CANCER RISK; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; OCCUPATIONAL HAZARD; PRIORITY JOURNAL;

EID: 0035393497     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Role of N-acetyltransferase phenotypes in bladder carcinogenesis: A pharmacogenetic epidemiological approach to bladder cancer
2. N-acetyltransferase phenotype and risk in urinary bladder cancer: Approaches in molecular epidemiology. Preliminary results in Sweden and Denmark
3. Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens
4. Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk
5. Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer
6. Expression of N-acetyltransferase (NAT) in cultured human uroepithelial cells
7. Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: Effects of 7 specific NAT2 nucleic acid substitutions
8. Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus
9. Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: Association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue
10. The role of N-acetylation polymorphism in smoking-associated bladder cancer: Evidence of a gene-gene-exposure three-way interaction
11. Role of aromatic amine acetyltransferases, NAT1 and NAT2, in carcinogen-DNA adduct formation in the human urinary bladder
12. Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: The influence of smoking
13. Correlation between genotype and phenotype of the human arylamine N-acetyltransferase type 1 (NAT1)
14. Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations
15. Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe
16. Update on consensus arylamine N-acetyltransferase gene nomenclature
17. Proportion of lung and bladder cancers in males resulting from occupation: A systematic approach
18. Occupational risks of bladder cancer in the United States: I. White men
19. Association of arylamine N-acetyltransferases NAT1 and NAT2 genotypes to laryngeal cancer risk
20. Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: Correlation with phenotypic activity
21. Homozygous rapid arylamine N-acetyltransferase NAT2 genotype as susceptibility factor for lung cancer
22. Characterization of naturally occurring and recombinant human N-acetyltransferase variants encoded by NAT1
23. Cigarette smoking, N-acetyltransferase 2 acetylation status, and bladder cancer risk: A case-series meta-analysis of a gene-environment interaction
24. NAT2 slow acetylation and bladder cancer risk: A meta-analysis of 22 case-control studies conducted in the general population
25. Aromatic and heterocyclic amine metabolism and phenotyping in humans
26. Metabolic activation of heterocyclic aromatic amines catalyzed by human arylamine N-acetyltransferase isozymes (NAT1 and NAT2) expressed in Salmonella typhimurium
27. DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in colon, bladder, and kidney of congenic mice differing in Ah responsiveness and N-acetyltransferase genotype
28. Diverse point mutations in the human gene for polymorphic N-acetyltransferase
29. Human N-acetylation of benzidine: Role of NAT1 and NAT2
30. Chapter 20. Polymorphic NATs and cancer predisposition
31. Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas
32. Lack of association between the polyadenylation polymorphism in the NAT1 (acetyltransferase 1) gene and colorectal caminomas
33. Placental expression of arylamine N-acetyltransferases: Evidence for linkage disequilibrium between NAT1*10 and NAT2*4 alleles of the two human arylamine N-acetyltransferase loci NAT1 and NAT2
34. Mapping AAC1, AAC2, and AACP, the genes for arylamine N-acetyltransferases, carcinogen metabolising enzymes on human chromosome 8p22, a region frequently deleted in tumours
35. Diet, acetylator phenotype, and risk of colorectal neoplasia
36. A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer
37. Molecular genetics of cancer susceptibility