Individual patient- versus group-level data meta-regressions for the investigation of treatment effect modifiers: Ecological bias rears its ugly head

Statistics in Medicine

Volumn 21, Issue 3, 2002, Pages 371-387

  Berlin, Jesse A ^a   Santanna, Jill ^b   Schmid, Christopher H ^c   Szczech, Lynda A ^a   Feldman, Harold I ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Ecological bias; Heterogeneity; Hierarchical models; Meta analysis; Subgroup analyses

Indexed keywords

ANTIBODY; AZATHIOPRINE; CYCLOSPORIN; LYMPHOCYTE ANTIBODY; OKT 3; PANEL REACTIVE ANTIBODY; PREDNISONE; UNCLASSIFIED DRUG;

ARTICLE; BAYES THEOREM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG COST; DRUG EFFICACY; ECOLOGY; HUMAN; INDIVIDUAL BASED POPULATION MODEL; INTERMETHOD COMPARISON; KIDNEY ALLOGRAFT REJECTION; KIDNEY TRANSPLANTATION; LOGISTIC REGRESSION ANALYSIS; META ANALYSIS; PATIENT INFORMATION; POPULATION DISTRIBUTION; PUBLISHING; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT;

BIAS (EPIDEMIOLOGY); HUMANS; INDIVIDUALITY; KIDNEY TRANSPLANTATION; LYMPHOCYTES; META-ANALYSIS; MODELS, STATISTICAL; REGRESSION ANALYSIS; TRANSPLANTATION TOLERANCE;

EID: 0037083255     PISSN: 02776715     EISSN: None     Source Type: Journal    
DOI: 10.1002/sim.1023     Document Type: Article

References (45)

1. Exploring heterogeneity in randomized trials via meta-analysis
2. Summing up evidence: One answer is not always enough
3. Invited commentary: Benefits of heterogeneity in meta-analysis of data from epidemiologic studies
4. A random-effects regression model for meta-analysis
5. Heterogeneity in meta-analysis of data from epidemiologic studies: A commentary
6. Meta-analysis. Beyond the grand mean?
7. Spurious precision? Meta-analysis of observational studies
8. Detecting and describing heterogeneity in meta-analysis
9. Investigating underlying risk as a source of heterogeneity in meta-analysis
10. Meta-analysis of the literature or of individual patient data: Is there a difference?
11. Comparison of effect estimates from a meta-analysis of summary data from published studies and from a meta-analysis using individual patient data for ovarian cancer studies
12. Obtaining data from randomised controlled trials: How much do we need for reliable and informative meta-analyses?
13. A comparison of meta-analytic results using literature vs individual patient data. Paternal cell immunization for recurrent miscarriage
14. Comparison of meta-analysis versus analysis of variance of individual patient data
15. Analysis and interpretation of treatment effects in subgroups of patients in randomized clinical trials
16. Uses of ecologic analysis in epidemiologic research
17. Accepting the limits of ecologic studies: Drs. Greenland and Robins reply to Drs. Piantadosi and Cohen
18. Invited commentary: Ecologic studies-biases, misconceptions, and counterexamples
19. The logic in ecological: II. The logic of design
20. The logical in ecological: I. The logic of analysis
21. The fallacy of the ecological fallacy: The potential misuse of a concept and the consequences
22. Invited commentary: Ecologic biases
23. Ecological analysis of intended treatment effects: Caveat emptor
24. A randomized clinical trial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants
25. Low-dose maintenance prednisone and antilymphoblast globulin for the treatment of acute rejection. A steroid-sparing approach to immunosuppressive therapy
26. The effect of antilymphocyte induction therapy on renal allograft survival. A meta-analysis of individual patient-level data. Anti-Lymphocyte Antibody Induction Therapy Study Group
27. Increased incidence of lymphoproliferative disorder after immunosuppression with the monoclonal antibody OKT3 in cardiac-transplant recipients
28. Complications and monitoring of OKT3 therapy
29. Effect of anti-lymphocyte induction therapy on renal allograft survival: A meta-analysis
30. Explaining heterogeneity in meta-analysis: A comparison of methods
31. Comparison of antilymphocyte globulin and continuous i.v. cyclosporine A as induction immunosuppression for cadaver kidney transplants: A prospective randomized study
32. The long-term effects of prophylactic OKT3 monoclonal antibody in cadaver kidney transplantation-a single-center, prospective, randomized study
33. A randomized clinical trial of induction therapy with OKT3 in kidney transplantation
34. A prospective randomized comparison of quadruple versus triple therapy for first cadaver transplants with immediate function
35. Cyclosporine monotherapy versus OKT3 and cyclosporine versus prednisone and cyclosporine as induction therapy in older renal transplant patients: A multicenter randomized study
36. The statistical basis of meta-analysis
37. Computer-modeling and graphical strategies for meta-analysis
38. Bayesian meta-analysis
39. The population risk as an explanatory variable in research synthesis of clinical trials
40. Large trials vs meta-analysis of smaller trials: How do their results compare?
41. Bayesian approaches to random-effects meta-analysis: A comparative study
42. An empirical comparison of several clustered data approaches under confounding due to cluster effects in the analysis of complications of coronary angioplasty
43. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials