메뉴 건너뛰기




Volumn 276, Issue 16, 1996, Pages 1332-1338

Large trials vs meta-analysis of smaller trials: How do their results compare?

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL TRIAL; DRUG RESEARCH; EPIDEMIOLOGICAL DATA; HUMAN; INCIDENCE; META ANALYSIS; POPULATION RESEARCH; PRIORITY JOURNAL; REVIEW; SAMPLE; STATISTICAL ANALYSIS; STATISTICAL MODEL;

EID: 0029957686     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.276.16.1332     Document Type: Review
Times cited : (320)

References (62)
  • 2
    • 0006725180 scopus 로고
    • Should intravenous magnesium be given to patients with acute myocardial infarction?
    • Lau J, Chalmers TC. Should intravenous magnesium be given to patients with acute myocardial infarction? Clin Res. 1994;42:290A.
    • (1994) Clin Res. , vol.42
    • Lau, J.1    Chalmers, T.C.2
  • 3
    • 0028826067 scopus 로고
    • Discordance between meta-analyses and large-scale randomized, control trials
    • Borzak S, Ridker PM. Discordance between meta-analyses and large-scale randomized, control trials. Ann Intern Med. 1995;123:873-877.
    • (1995) Ann Intern Med. , vol.123 , pp. 873-877
    • Borzak, S.1    Ridker, P.M.2
  • 4
    • 0027964763 scopus 로고
    • Relative role of meta-analysis and randomized controlled trials in the assessment of medical therapies
    • Domanski MJ, Friedman LM. Relative role of meta-analysis and randomized controlled trials in the assessment of medical therapies. Am J Cardiol. 1994; 74:395-396
    • (1994) Am J Cardiol. , vol.74 , pp. 395-396
    • Domanski, M.J.1    Friedman, L.M.2
  • 5
    • 0029097774 scopus 로고
    • Mega-trials and management of acute myocardial infarction
    • Woods KL. Mega-trials and management of acute myocardial infarction. Lancet. 1995;346:611-614.
    • (1995) Lancet , vol.346 , pp. 611-614
    • Woods, K.L.1
  • 6
    • 0028958766 scopus 로고
    • Magnesium in acute myocardial infarction
    • Yusuf S, Flather M. Magnesium in acute myocardial infarction. BMJ. 1995;310:751-752.
    • (1995) BMJ , vol.310 , pp. 751-752
    • Yusuf, S.1    Flather, M.2
  • 7
    • 0028964587 scopus 로고
    • Misleading meta-analysis
    • Egger M, Davey Smith G. Misleading meta-analysis. BMJ. 1995;310:752-754.
    • (1995) BMJ , vol.310 , pp. 752-754
    • Egger, M.1    Davey Smith, G.2
  • 8
    • 0028879315 scopus 로고
    • Nitrates in myocardial infarction: A current perspective
    • Morris JL, Cowan Campbell J. Nitrates in myocardial infarction: a current perspective. Can J Cardiol. 1995;11:5B-10B.
    • (1995) Can J Cardiol. , vol.11
    • Morris, J.L.1    Cowan Campbell, J.2
  • 9
    • 0023260901 scopus 로고
    • Meta-analysie of clinical trials as a scientific discipline, I: Control of bias and comparison with large co-operative trials
    • Chalmers TC, Levin H, Sacks HS, Reitman D, Berrier J, Nagalingam R. Meta-analysie of clinical trials as a scientific discipline, I: control of bias and comparison with large co-operative trials. Stat Med. 1987;6:315-325.
    • (1987) Stat Med. , vol.6 , pp. 315-325
    • Chalmers, T.C.1    Levin, H.2    Sacks, H.S.3    Reitman, D.4    Berrier, J.5    Nagalingam, R.6
  • 10
    • 0028911125 scopus 로고
    • Predictive ability of meta-analyses of randomised controlled trials
    • Villar J, Carroli G, Belizan JM. Predictive ability of meta-analyses of randomised controlled trials. Lancet. 1995;345:772-776.
    • (1995) Lancet , vol.345 , pp. 772-776
    • Villar, J.1    Carroli, G.2    Belizan, J.M.3
  • 11
    • 0029651938 scopus 로고
    • Do small trials square with large ones?
    • Flournoy N, Olkin I. Do small trials square with large ones? Lancet. 1995;345:741-742.
    • (1995) Lancet , vol.345 , pp. 741-742
    • Flournoy, N.1    Olkin, I.2
  • 12
    • 0029114082 scopus 로고
    • Meta-meta-analysis with confidence
    • Lumley T, Keech A. Meta-meta-analysis with confidence. Lancet. 1995;346:576-577.
    • (1995) Lancet , vol.346 , pp. 576-577
    • Lumley, T.1    Keech, A.2
  • 13
    • 0029648747 scopus 로고
    • Meta-analyses of interventional trials done in populations with different risks
    • Gonser M, Vetter K, Noack F. Meta-analyses of interventional trials done in populations with different risks. Lancet. 1995;345:1304-1305.
    • (1995) Lancet , vol.345 , pp. 1304-1305
    • Gonser, M.1    Vetter, K.2    Noack, F.3
  • 15
    • 10244237399 scopus 로고
    • Graphical exploratory analysis of variance illustrated on a splitting of the Johnson and Tsao data
    • Mallows CL, ed. New York, NY: John Wiley & Sons;
    • Johnson EG, Tukey JW. Graphical exploratory analysis of variance illustrated on a splitting of the Johnson and Tsao data. In: Mallows CL, ed. Design, Data, and Analysis: By Some Friends of Cuthbert Daniel. New York, NY: John Wiley & Sons; 1987: 171-244.
    • (1987) Design, Data, and Analysis: by Some Friends of Cuthbert Daniel , pp. 171-244
    • Johnson, E.G.1    Tukey, J.W.2
  • 17
    • 0039531299 scopus 로고
    • Boston, Mass: Little Brown & Co;
    • Rothman KJ. Modern Epidemiology. Boston, Mass: Little Brown & Co; 1986:177-236.
    • (1986) Modern Epidemiology , pp. 177-236
    • Rothman, K.J.1
  • 18
    • 0029057799 scopus 로고
    • Early or deferred zidovudine therapy in HIV-infected patients without an AIDS-defining illness: A meta-analysis
    • Ioannidis JPA, Cappelleri JC, Lau J, et al. Early or deferred zidovudine therapy in HIV-infected patients without an AIDS-defining illness: a meta-analysis. Ann Intern Med. 1995;122:856-866.
    • (1995) Ann Intern Med. , vol.122 , pp. 856-866
    • Ioannidis, J.P.A.1    Cappelleri, J.C.2    Lau, J.3
  • 20
    • 0028926350 scopus 로고
    • Randomized trials of magnesium in acute myocardial infarction: Big numbers do not tell the whole story
    • Antman EM. Randomized trials of magnesium in acute myocardial infarction: big numbers do not tell the whole story. Am J Cardiol. 1995;75:391-393.
    • (1995) Am J Cardiol. , vol.75 , pp. 391-393
    • Antman, E.M.1
  • 21
    • 0027765280 scopus 로고
    • Controversies in meta-analysis: The case of the trials of serum cholesterol reduction
    • Thompson SG. Controversies in meta-analysis: the case of the trials of serum cholesterol reduction. Stat Methods Med Res. 1993;2:173-192.
    • (1993) Stat Methods Med Res. , vol.2 , pp. 173-192
    • Thompson, S.G.1
  • 22
    • 0027153371 scopus 로고
    • Cholesterol lowering and mortality: The importance of considering initial level of risk
    • Smith GD, Song F, Sheldon RA. Cholesterol lowering and mortality: the importance of considering initial level of risk. BMJ. 1993;306:1367-1373.
    • (1993) BMJ , vol.306 , pp. 1367-1373
    • Smith, G.D.1    Song, F.2    Sheldon, R.A.3
  • 23
    • 0027328643 scopus 로고
    • An effect model for the assessment of drug benefit: Example of antiarrhythmic drugs in postmyocardial infarction patients
    • Boissel JP, Collet JP, Lievre M, Girard P. An effect model for the assessment of drug benefit: example of antiarrhythmic drugs in postmyocardial infarction patients. J Cardiovasc Pharmacol. 1993; 22:356-363.
    • (1993) J Cardiovasc Pharmacol. , vol.22 , pp. 356-363
    • Boissel, J.P.1    Collet, J.P.2    Lievre, M.3    Girard, P.4
  • 25
    • 0029023726 scopus 로고
    • Can overall results of clinical trials be applied to all patients?
    • Rotwell M. Can overall results of clinical trials be applied to all patients? Lancet. 1995;345:1616-1619.
    • (1995) Lancet , vol.345 , pp. 1616-1619
    • Rotwell, M.1
  • 26
    • 0002629270 scopus 로고
    • Maximum likelihood from incomplete data via the EM algorithm
    • Dempster AP, Laird NM, Rubin DB. Maximum likelihood from incomplete data via the EM algorithm. J R Stat Soc. 1977;38:1-22.
    • (1977) J R Stat Soc. , vol.38 , pp. 1-22
    • Dempster, A.P.1    Laird, N.M.2    Rubin, D.B.3
  • 27
    • 0029766918 scopus 로고    scopus 로고
    • The population risk as an explanatory variable in research synthesis of clinical trials
    • McIntosh M. The population risk as an explanatory variable in research synthesis of clinical trials. Stat Med. 1996;15:1713-1728.
    • (1996) Stat Med. , vol.15 , pp. 1713-1728
    • McIntosh, M.1
  • 29
    • 0028659004 scopus 로고
    • Operating characteristics of a rank correlation test for publication bias
    • Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088-1101.
    • (1994) Biometrics , vol.50 , pp. 1088-1101
    • Begg, C.B.1    Mazumdar, M.2
  • 30
    • 2442751430 scopus 로고
    • Boston, Mass: New England Medical Center
    • Lau J. Meta-Analyst. Version 0.988. Boston, Mass: New England Medical Center; 1995.
    • (1995) Meta-Analyst. Version 0.988
    • Lau, J.1
  • 31
    • 0003454669 scopus 로고
    • Cambridge, Mass: MathSoft Inc
    • MathSoft, Inc. Mathcad Plus 6.0. Cambridge, Mass: MathSoft Inc; 1995.
    • (1995) Mathcad Plus 6.0
  • 32
    • 0003445803 scopus 로고
    • Seattle, Wash: StatSci, MathSoft Inc
    • Statistical Sciences Inc. S-PLUS User's Manual. Version 3.2. Seattle, Wash: StatSci, MathSoft Inc; 1993.
    • (1993) S-PLUS User's Manual. Version 3.2
  • 34
    • 0029029729 scopus 로고
    • Overview of clinical trials comparing natural and synthetic surfactants
    • Halliday HL. Overview of clinical trials comparing natural and synthetic surfactants. Biol Neonate. 1995;67(suppl 1):32-47.
    • (1995) Biol Neonate. , vol.67 , Issue.1 SUPPL. , pp. 32-47
    • Halliday, H.L.1
  • 35
    • 0028932732 scopus 로고
    • ISIS-4: A randomized factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients in suspected acute myocardial infarction
    • ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group. ISIS-4: a randomized factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients in suspected acute myocardial infarction. Lancet. 1995;345:669-685.
    • (1995) Lancet , vol.345 , pp. 669-685
  • 36
    • 0027909356 scopus 로고
    • Early angiography and angioplasty following thrombolytic therapy of acute myocardial infarction: Metaanalyses of the randomized control trials
    • [serial online]. June 5, doc 67
    • Jovell AJ, Lau J, Berkey C, Kupelnick B, Chalmers TC. Early angiography and angioplasty following thrombolytic therapy of acute myocardial infarction: metaanalyses of the randomized control trials. Online J Curr Clin Trials [serial online]. June 5, 1993; doc 67.
    • (1993) Online J Curr Clin Trials
    • Jovell, A.J.1    Lau, J.2    Berkey, C.3    Kupelnick, B.4    Chalmers, T.C.5
  • 37
    • 0025947995 scopus 로고
    • Aspirin and fibrinolysis in acute myocardial infarction: Meta-analytic evidence for synergy
    • Basinki A, Naylor CD. Aspirin and fibrinolysis in acute myocardial infarction: meta-analytic evidence for synergy. J Clin Epidemiol. 1991;44:1085-1096.
    • (1991) J Clin Epidemiol. , vol.44 , pp. 1085-1096
    • Basinki, A.1    Naylor, C.D.2
  • 38
    • 0025148559 scopus 로고
    • Impact of intravenous thrombolysis on short-term coronary revascularization rates: A meta-analysis
    • Naylor CD, Jaglal SB. Impact of intravenous thrombolysis on short-term coronary revascularization rates: a meta-analysis. JAMA. 1990;264:697-702.
    • (1990) JAMA , vol.264 , pp. 697-702
    • Naylor, C.D.1    Jaglal, S.B.2
  • 39
    • 0028120906 scopus 로고
    • Collaborative overview of randomised trials of antiplatelet therapy, I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients
    • Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy, I: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ. 1994;308: 81-106.
    • (1994) BMJ , vol.308 , pp. 81-106
  • 40
    • 0028837190 scopus 로고
    • Drugs and surgery in the prevention of ischemic stroke
    • Barnett HJM, Eliasziw M, Meldrum HE. Drugs and surgery in the prevention of ischemic stroke. N Engl J Med. 1995;332:238-248.
    • (1995) N Engl J Med. , vol.332 , pp. 238-248
    • Barnett, H.J.M.1    Eliasziw, M.2    Meldrum, H.E.3
  • 41
    • 0028812686 scopus 로고
    • Meta-analysis of randomised trials comparing coronary angioplasty with bypass surgery
    • Pocock SJ, Henderson RA, Rickards AF, et al. Meta-analysis of randomised trials comparing coronary angioplasty with bypass surgery. Lancet. 1995; 346:1184-1189.
    • (1995) Lancet , vol.346 , pp. 1184-1189
    • Pocock, S.J.1    Henderson, R.A.2    Rickards, A.F.3
  • 42
    • 10244240224 scopus 로고    scopus 로고
    • Efficacy and safety of different aspirin dosages on vascular diseases: A meta-regression analysis
    • [serial online]. March 14, doc 174
    • Cappelleri JC, Lau J, Kupelnick B, Chalmers TC. Efficacy and safety of different aspirin dosages on vascular diseases: a meta-regression analysis. Online J Curr Clin Trials [serial online]. March 14, 1998; doc 174.
    • (1998) Online J Curr Clin Trials
    • Cappelleri, J.C.1    Lau, J.2    Kupelnick, B.3    Chalmers, T.C.4
  • 43
    • 0026557343 scopus 로고
    • Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy: 133 randomised trials involving 31 000 recurrences and 24 000 deaths among 75 000 women
    • Early Breast Cancer Trialists' Collaborative Group. Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy: 133 randomised trials involving 31 000 recurrences and 24 000 deaths among 75 000 women. Lancet. 1992;339:1-15, 71-85.
    • (1992) Lancet , vol.339 , pp. 1-15
  • 44
    • 0028791012 scopus 로고
    • Effects of radiotherapy and surgery in early breast cancer an overview of the randomized trials
    • Early Breast Cancer Trialists' Collaborative Group. Effects of radiotherapy and surgery in early breast cancer an overview of the randomized trials. N Engl J Med. 1995;333:1444-1455.
    • (1995) N Engl J Med. , vol.333 , pp. 1444-1455
  • 45
    • 0026761832 scopus 로고
    • Low molecular weight heparin in prevention of perioperative thrombosis
    • Leizorovicz A, Haugh MC, Chapuis FR, Samama MM, Boissel JP. Low molecular weight heparin in prevention of perioperative thrombosis. BMJ. 1992;305:913-920.
    • (1992) BMJ , vol.305 , pp. 913-920
    • Leizorovicz, A.1    Haugh, M.C.2    Chapuis, F.R.3    Samama, M.M.4    Boissel, J.P.5
  • 46
    • 0028217263 scopus 로고
    • Collaborative overview of randomised trials of antiplatelet therapy, III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients
    • Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy, III: reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. BMJ. 1994; 308:235-246.
    • (1994) BMJ , vol.308 , pp. 235-246
  • 47
    • 0028128106 scopus 로고
    • Collaborative overview of randomised trials of antiplatelet therapy, II: Maintenance of vascular graft or arterial patency by antiplatelet therapy
    • Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy, II: maintenance of vascular graft or arterial patency by antiplatelet therapy. BMJ. 1994; 308:159-168.
    • (1994) BMJ , vol.308 , pp. 159-168
  • 48
    • 0028593932 scopus 로고
    • Drug treatment of hypertension in the elderly: A meta-analysis
    • Insua JT, Sacks HS, Lau TS, et al. Drug treatment of hypertension in the elderly: a meta-analysis. Ann Intern Med. 1994;121:355-362.
    • (1994) Ann Intern Med. , vol.121 , pp. 355-362
    • Insua, J.T.1    Sacks, H.S.2    Lau, T.S.3
  • 49
    • 0025347391 scopus 로고
    • Blood pressure, stroke and coronary heart disease, II: Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context
    • Collins R, Peto R, MacMahon S, et al. Blood pressure, stroke and coronary heart disease, II: short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet. 1990;335:827-838.
    • (1990) Lancet , vol.335 , pp. 827-838
    • Collins, R.1    Peto, R.2    MacMahon, S.3
  • 50
    • 0028955321 scopus 로고
    • Overview of randomized trials of angìotensín-converting enzyme inhibitors on mortality and morbidity in patients with heart failure
    • Garg R, Yusuf S, for the Collaborative Group on ACE Inhibitor Trials. Overview of randomized trials of angìotensín-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. JAMA. 1995;273:1450-1456.
    • (1995) JAMA , vol.273 , pp. 1450-1456
    • Garg, R.1    Yusuf, S.2
  • 51
    • 0028351475 scopus 로고
    • Evaluation of the effect of phosphodiesterase inhibitors on mortality in chronic heart failure patients: A meta-analysis
    • Nony P, Boissel JP, Lievre M, et al. Evaluation of the effect of phosphodiesterase inhibitors on mortality in chronic heart failure patients: a meta-analysis. Eur J Clin Pharmacol. 1994;46:191-196.
    • (1994) Eur J Clin Pharmacol. , vol.46 , pp. 191-196
    • Nony, P.1    Boissel, J.P.2    Lievre, M.3
  • 52
    • 0027473510 scopus 로고
    • Vitamin A supplementation in infectious diseases: A meta-analysis
    • Glasziou PP, Mackerras DEM. Vitamin A supplementation in infectious diseases: a meta-analysis. BMJ. 1993;306:366-370.
    • (1993) BMJ , vol.306 , pp. 366-370
    • Glasziou, P.P.1    Mackerras, D.E.M.2
  • 54
    • 0028233466 scopus 로고
    • The effectiveness of the nicotine patch for smoking cessation: A meta-analysis
    • Fiore MC, Smith SS, Jorenby DE, Baker TB. The effectiveness of the nicotine patch for smoking cessation: a meta-analysis. JAMA. 1994;271:1940-1947.
    • (1994) JAMA , vol.271 , pp. 1940-1947
    • Fiore, M.C.1    Smith, S.S.2    Jorenby, D.E.3    Baker, T.B.4
  • 56
    • 0029983193 scopus 로고    scopus 로고
    • The importance of quality of primary studies in producing unbiased systematic reviews
    • Khan KS, Daya S, Jadad AR. The importance of quality of primary studies in producing unbiased systematic reviews. Arch Intern Med. 1996;156: 661-666.
    • (1996) Arch Intern Med. , vol.156 , pp. 661-666
    • Khan, K.S.1    Daya, S.2    Jadad, A.R.3
  • 57
    • 0028018289 scopus 로고
    • Clinically useful measures of effect in binary analyses of randomized trials
    • Sinclair JC, Bracken MB. Clinically useful measures of effect in binary analyses of randomized trials. J Clin Epidemiol. 1994;47:881-889.
    • (1994) J Clin Epidemiol. , vol.47 , pp. 881-889
    • Sinclair, J.C.1    Bracken, M.B.2
  • 58
    • 0002874303 scopus 로고
    • Fixed effects models
    • Cooper H, Hedges LV, eds. New York, NY: Russell Sage Foundation
    • Hedges LV. Fixed effects models. In: Cooper H, Hedges LV, eds. The Handbook of Research Synthesis. New York, NY: Russell Sage Foundation; 1994:285-299.
    • (1994) The Handbook of Research Synthesis , pp. 285-299
    • Hedges, L.V.1
  • 59
    • 0002285113 scopus 로고
    • Random effects models
    • Cooper H, Hedges LV, eds. New York, NY: Russell Sage Foundation
    • Raudenbush SW. Random effects models. In: Cooper H, Hedges LV, eds. The Handbook of Research Synthesis. New York, NY: Russell Sage Foundation; 1994:301-321.
    • (1994) The Handbook of Research Synthesis , pp. 301-321
    • Raudenbush, S.W.1
  • 60
    • 0027872361 scopus 로고
    • Large-scale randomized evidence: Large, simple trials and overviews of trials
    • Warren KS, Mosteller F, eds. New York, NY: New York Academy of Sciences
    • Peto R, Collins R, Gray R. Large-scale randomized evidence: large, simple trials and overviews of trials. In: Warren KS, Mosteller F, eds. Doing More Good Than Harm: The Evaluation of Health Care Interventions. New York, NY: New York Academy of Sciences; 1993:314-340.
    • (1993) Doing More Good Than Harm: the Evaluation of Health Care Interventions , pp. 314-340
    • Peto, R.1    Collins, R.2    Gray, R.3
  • 62
    • 0021745696 scopus 로고
    • Why do we need some large, simple randomized trials?
    • Yusuf S, Collins R, Peto R. Why do we need some large, simple randomized trials? Stat Med. 1984;3: 409-420.
    • (1984) Stat Med. , vol.3 , pp. 409-420
    • Yusuf, S.1    Collins, R.2    Peto, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.