Insulin receptor tyrosine kinase activity and phosphorylation of tyrosines 1162 and 1163 are required for insulin-increased prolactin gene expression

Molecular and Cellular Endocrinology

Volumn 186, Issue 1, 2002, Pages 7-16

  Jacob, Kirsten K ^a   Whittaker, Jonathan ^b   Stanley, Frederick M ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HAGEDORN RESEARCH INSTITUTE   (Denmark)

Author keywords

Gene transcription; Insulin receptor; Mutants; Prolactin

Indexed keywords

INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR KINASE; PROLACTIN; TYROSINE;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE MUTATION; IMMUNOPRECIPITATION; INSULIN BINDING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; RAT; TRANSCRIPTION REGULATION;

EID: 0037081887     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(01)00674-8     Document Type: Article

References (28)

1. APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase
2. Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin
3. Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose
4. cis-Acting elements of the rat growth hormone gene which mediate basal and regulated expression by thyroid hormone
5. The pathway mediating insulin's effects on pyruvate dehydrogenase bypasses the insulin receptor tyrosine kinase
6. The protein kinase family; conserved features and deduced phylogeny of the catalytic domains
7. Binding of insulin receptors to lectins: evidence for common carbohydrate determinants on several membrane receptors
8. Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog
9. Crystal structure of the tyrosine kinase domain of the insulin receptor
10. A consensus insulin response element is activated by an ETS-related transcription factor
11. Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor
12. Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction
13. A family of proteins that inhibit signalling through tyrosine kinase receptors
14. SH2-Ba is an insulin receptor adapter protein and substrate that interacts with the activation loop of the insulin receptor kinase
15. Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phosphoinositide 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects
16. Rapid and efficient site-specific mutagenesis without phenotypic selection
17. Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain
18. Insulin regulates prolactin secretion and messenger ribonucleic acid levels in pituitary cells
19. Mutation of tyrosine residues 1162 and 1163 of the insulin receptor affects hormone and receptor internalization
20. Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor
21. Transcriptional regulation of prolactin gene expression by thyroid hormone: alternate suppression and stimulation in different GH cell lines
22. An element in the prolactin promoter mediates the stimulation of insulin on transcription of the prolactin gene
23. Alteration in prolactin secretion in streptozotocin-induced diabetic rats. Correlation with pituitary and hypothalamus estradiol receptors
24. High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells
25. The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth
26. Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function