Development of a new drug delivery system for protein drugs using silicone (II)

Journal of Controlled Release

Volumn 73, Issue 2-3, 2001, Pages 279-291

  Kajihara, Masako ^a   Sugie, Toshihiko ^a   Hojo, Takami ^a   Maeda, Hiroo ^a   Sano, Akihiko ^a   Fujioka, Keiji ^a   Sugawara, Shuichi ^b   Urabe, Yosuke ^b  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b Dow Corning Asia Ltd   (Japan)

Author keywords

Covered rod; Interferon; Release mechanism; Silicone; Zero order

Indexed keywords

HUMAN SERUM ALBUMIN; INTERFERON; SILASTIC; SILICONE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG FORMULATION; DRUG RELEASE; FEMALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL;

ANIMALS; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; FEMALE; INTERFERONS; MICE; MICE, INBRED BALB C; PARTICLE SIZE; PROTEINS; SERUM ALBUMIN; SILICONES;

EID: 0035850216     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00302-9     Document Type: Article

References (15)

1. Controlled release of polypeptides and other macromolecules
2. An osmotically driven implantable therapeutic system for the human delivery of peptides and proteins
3. Development of new drug delivery system for protein drugs for protein drugs using silicone (I)
4. Texas red, a hydrophilic, red-emitting fluorophore for use with fluorescein in dual parameter flow microfluorometric and fluorescence microscopic studies
5. One-month release injectable microspheres of leuprolide acetate, a superactive agonist of LH-RH
6. Three-months release injectable microspheres of leuprorelin acetate
7. One- and three-month release injectable microspheres of the LH-RH superagonist leuprorelin acetate
8. Sustained pharmacological activities in rats following single and repeated administration of once-a-month injectable microspheres of leuprolide acetate
9. A month-long effect from a single injection of microencapsulated human growth hormone
10. Recombinant human growth hormone poly(lactic-co-glycolic acid) microsphere formulation development
11. The stabilization and encapsulation of human growth hormone into biodegradable microspheres
12. A large-scale process to produce microencapsulated proteins
13. Improving protein therapeutics with sustained-release formulations
14. Present and future applications of biomaterials in controlled drug delivery systems
15. The antitumor effects of human lymphoblastoid interferon on human renal cell carcinoma in athymic nude mice