Delivery of exogenous protein antigens to major histocompatibility complex class I pathway in cytosol

Journal of Infectious Diseases

Volumn 185, Issue 2, 2002, Pages 244-251

  Cao, Huyen ^a   Agrawal, Deepak ^b   Kushner, Nicholas ^c   Touzjian, Neal ^c   Essex, Max ^c   Lu, Yichen ^c  

^a CA Department of Public Health   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; RECOMBINANT ANTIGEN; RECOMBINANT PROTEIN;

ANTHRAX; ARTICLE; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIGEN PRESENTATION; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; CARRIER PROTEINS; CELL LINE; CHLOROQUINE; CYTOSOL; HISTOCOMPATIBILITY ANTIGENS CLASS I; HIV ANTIGENS; HUMANS; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0037080208     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/338448     Document Type: Article

References (41)

1. Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
2. Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
3. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
4. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
5. ENV-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids
6. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women
7. Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast
8. Proteolysis, proteasomes and antigen presentation
9. Supply and transport of peptides presented by class I MHC molecules
10. MHC class I/beta 2-microglobulin complexes associate with TAP transporters before peptide binding
11. Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP
12. Prominence of beta 2-microglobulin, class I heavy chain conformation, and tapasin in the interactions of class I heavy chain with calreticulin and the transporter associated with antigen processing
13. Interaction of MHC class 1 molecules with the transporter associated with antigen processing
14. Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo
15. Anthrax toxin-mediated delivery in vivo and in vitro of a cytotoxic T-lymphocyte epitope from ovalbumin
16. Targeting HIV proteins to the major histocompatibility complex class I processing pathway with a novel gp120-anthrax toxin fusion protein
17. Genetically modified anthrax lethal toxin safely delivers whole HIV protein antigens into the cytosol to induce T cell immunity
18. Anthrax toxin edema factor: A bacterial adenylate cyclase that increases cyclic AMP concentration of eukaryotic cells
19. Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity
20. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
21. Role of macrophage oxidative burst in the action of anthrax lethal toxin
22. Anthrax protective antigen forms oligomers during intoxication of mamalian cells
23. Crystal structure of anthrax toxin protective antigen
24. Protective antigen-binding domain of anthrax lethal factor mediates translocation of a heterologous protein fused to its amino- or carboxyl-terminus
25. Cytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: Implication for vaccine development
26. Cellular immunity to human immunodeficiency virus type 1 (HIV-1) clades: Relevance to HIV-1 vaccine trials in Uganda
27. Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner
28. Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter
29. Major histocompatibility complex class I molecules interact with both subunits of the transporter associated with antigen processing, TAP1 and TAP2
30. Intracellular transport of class I MHC molecules in antigen processing mutant cell lines
31. Role of endogenous peptide in human alloreactive cytotoxic T cell responses
32. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides
33. Endocytosis of particulate and soluble IgG immune complexes: Differential effects of cytoskeletal modulating agents
34. Cytochalasin B. Dissociation of pinocytosis and phagocytosis by peritoneal macrophages
35. Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes
36. Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules
37. Phagocytic processing of bacterial antigens for class I MHC presentation to T cells
38. Roles of proteasomes, transporter for antigen presentation (TAP), and beta 2-microglobulin in the processing of bacterial or particulate antigens via an alternate class I MHC processing pathway
39. Temporal changes of lysosome and phagosome pH during phagolysosome formation in macrophages: Studies by fluorescence spectroscopy
40. Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents
41. Rapid effector function in CD8+ memory T cells