Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: Role of the GnRHR carboxyl-terminus

Molecular and Cellular Endocrinology

Volumn 191, Issue 2, 2002, Pages 149-156

  Castro Fernández, Cecilia ^a   Conn, P Michael ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Carboxyl terminus; G proteins; Gonadotropin releasing hormone; Gonadotropin releasing hormone receptor; GTPase activating proteins; RGS proteins

Indexed keywords

CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GONADORELIN RECEPTOR; RGS PROTEIN; RGS10 PROTEIN; RGS3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CHIMERA; CONTROLLED STUDY; DOSE RESPONSE; GENETIC TRANSCRIPTION; INTERNALIZATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; GENE EXPRESSION REGULATION; LIGANDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RATS; RECEPTORS, LHRH; RECOMBINANT FUSION PROTEINS; RGS PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0037077031     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(02)00082-5     Document Type: Article

References (36)

1. C-terminal truncation of the neurokinin-2 receptor causes enhanced and sustained agonist-induced signaling. Role of receptor phosphorylation in signal attenuation
2. Regulators of G protein signaling: A bestiary of modular protein binding domains
3. Regulation of RGS3 and RGS10 palmitoylation by gonadotropin-releasing hormone
4. Cytoplasmic, nuclear, and Golgi localization of the RGS proteins
5. A truncated form of RGS3 negatively regulates G protein-coupled receptor stimulation of adenylyl cyclase and phosphoinositide phospholipase C
6. RGS proteins: More than just GAPs for heterotrimeric G proteins
7. The regulators of G protein signaling family
8. RGS proteins and signaling by heterotrimeric G proteins
9. 2 receptor signaling, desensitization, and agonist-induced internalization
10. The use of lithium ion in measurement of stimulated pituitary inositol phospholipid turnover
11. Molecular cloning and characterization of a steroid receptor-binding regulator of G-protein signaling protein cDNA
12. Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell lines
13. Chimeric alpha 2-, beta 2-adrenergic receptors: Delineation of domains involved in effector coupling and ligand binding specificity
14. Regulation of G protein-mediated signal transduction by RGS proteins
15. Truncation of the receptor carboxyl terminus impairs agonist-dependent phosphorylation and desensitization of the alpha 1β-adrenergic receptor
16. G protein-coupled receptors III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization
17. Addition of catfish gonadotropin-releasing hormone (GnRH) receptor intracellular carboxyl-terminal tail to rat GnRH receptor alters receptor expression and regulation
18. Specific involvement of G proteins in regulation of serum response factor-mediated gene transcription by different receptors
19. Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein α subunit Gα13
20. The calcium requirement in GnRH-stimulated LH release is not mediated through a specific action on receptor binding
21. Potential role for a regulator of G protein signaling (RGS3) in gonadotropin-releasing hormone (GnRH) stimulated desensitization
22. Contrasting internalization kinetics of human and chicken gonadotropin-releasing hormone receptors mediated by C-terminal tail
23. 2 receptor
24. GTPase-activating proteins for heterotrimeric G proteins: Regulators of G protein signaling (RGS) and RGS-like proteins
25. The gonadotropin-releasing hormone receptor: Structural determinants and regulatory control
26. Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone
27. Regulators of G protein signaling in receptor complexes
28. RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III
29. 3 cells stably transfected with gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid
30. CHO-K1 cells. The carboxyl-terminal region directs agonist-induced internalization but not receptor signaling or desensitization
31. Role of regulator of G protein signaling in desensitization of the glucose-dependent insulinotropic peptide receptor
32. A novel regulator of G protein signaling in yeast, RGS2, down regulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2
33. Agonist-induced endocytosis and recycling of the gonadotropin-releasing hormone receptor: Effect of β-arrestin on internalization kinetics
34. Lack of a C-terminal tail in the mammalian gonadotropin-releasing hormone receptor confers resistance to agonist-dependent phosphorylation and rapid desensitization
35. RGS proteins determine signaling specificity of Gq-coupled receptors
36. The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling