Solid-phase synthesis of amine-bridged cyclic enkephalin analogues via on-resin cyclization utilizing the Fukuyama-Mitsunobu reaction

Journal of Organic Chemistry

Volumn 67, Issue 25, 2002, Pages 8820-8826

  Rew, Yosup ^a   Goodman, Murray ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE CYCLIZATION;

ADDITION REACTIONS; SYNTHESIS (CHEMICAL);

ORGANIC COMPOUNDS;

3 NITROBENZENESULFONYL DERIVATIVE; AMINE; AZODICARBOXYLIC ACID DIETHYL ESTER; CARBOXYLIC ACID DERIVATIVE; DIISOPROPYL AZODICARBOXYLATE; ENKEPHALIN DERIVATIVE; NITROBENZENE DERIVATIVE; RESIN; SULFONAMIDE; TRIPHENYLPHOSPHINE; UNCLASSIFIED DRUG; BRIDGED COMPOUND; CYCLOPEPTIDE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; ENKEPHALIN;

ARTICLE; CHEMICAL REACTION; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; SOLID; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINES; BRIDGED COMPOUNDS; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; CYCLIZATION; ENKEPHALINS; INDICATORS AND REAGENTS; MOLECULAR STRUCTURE; PEPTIDES, CYCLIC; RESINS, SYNTHETIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037073822     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo020447l     Document Type: Article

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