Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT1A receptors

Journal of Medicinal Chemistry

Volumn 45, Issue 19, 2002, Pages 4128-4139

  Orús, Lara ^a   Pérez Silanes, Silvia ^a   Oficialdegui, Ana M ^a   Martínez Esparza, Javier ^a   Del Castillo, Juan C ^b   Mourelle, Marisa ^b   Langer, Thierry ^c   Guccione, Salvatore ^d   Donzella, Giuseppina ^d   Krovat, Eva M ^c   Poptodorov, Konstantin ^c   Lasheras, Berta ^a   Ballaz, Santiago ^a   Hervías, Isabel ^a   Tordera, Rosa ^a   Del Río, Joaquín ^a   Monge, Antonio ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b Vita Invest SA Av Barcelona 69 08970 Sant Joan Despí ^*  (Spain)

^c UNIVERSITY OF INNSBRUCK   (Austria)

^d UNIVERSITY OF CATANIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PIPERAZINE DERIVATIVE; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FRONTAL CORTEX; HIPPOCAMPUS; HYPOTHERMIA; MOLECULAR MODEL; MOUSE; NEUROMODULATION; NONHUMAN; RAT; THERMOREGULATION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; CARRIER PROTEINS; FRONTAL LOBE; HIPPOCAMPUS; HYPOTHERMIA; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; PIPERAZINES; PROPANE; RADIOLIGAND ASSAY; RATS; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; STEREOISOMERISM;

EID: 0037068473     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0111200     Document Type: Article

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