Fusion proteins with COOH-terminal ubiquitin are stable and maintain dual functionality in vivo

Journal of Biological Chemistry

Volumn 277, Issue 41, 2002, Pages 38818-38826

  Qian, Shu Bing ^a   Ott, David E ^a   Schubert, Ulrich ^b   Bennink, Jack R ^a   Yewdell, Jonathan W ^a,b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CELLS; DEGRADATION; FLUORESCENCE; FUSION REACTIONS; IMMUNOLOGY; METABOLISM; VIRUSES;

IMMUNODEFICIENCY;

ENZYMES;

CARBOXYLIC ACID; HYBRID PROTEIN; HYDROLASE; PROTEASOME; UBIQUITIN;

ARTICLE; BIOSYNTHESIS; CHEMICAL REACTION; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; VIRUS PARTICLE;

AMINO ACID SEQUENCE; ANIMALS; HELA CELLS; HUMANS; HYDROLASES; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PEPTIDE HYDROLASES; PROTEASOME ENDOPEPTIDASE COMPLEX; RECOMBINANT FUSION PROTEINS; UBIQUITIN;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0037064071     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205547200     Document Type: Article

References (42)

1. Hershko, A., and Ciechanover, A. (1998) Annu. Rev. Biochem. 67, 425-479
2. Weissman, A. M. (2001) Nat. Rev. Mol. Cell. Biol. 2, 169-178
3. Breitschopf, K., Bengal, E., Ziv, T., Admon, A., and Ciechanover, A. (1998) EMBO J. 17, 5964-5973
4. Hochstrasser, M. (1996) Annu. Rev. Genet. 30, 405-439
5. Chau, V., Tobias, J. W., Bachmair, A., Marriott, D., Ecker, D. J., Gonda, D. K., and Varshavsky, A. (1989) Science 243, 1576-1583
6. Pickart, C. M. (2000) Trends Biochem. Sci. 25, 544-548
7. Deveraux, Q., Ustrell, V., Pickart, C., and Rechsteiner, M. (1994) J. Biol. Chem. 269, 7059-7061
8. Bachmair, A., and Varshavsky, A. (1989) Cell 56, 1019-1032
9. Johnson, E. S., Gonda, D. K., and Varshavsky, A. (1990) Nature 346, 287-291
10. Johnson, E. S., Ma, P. C., Ota, I. M., and Varshavsky, A. (1995) J. Biol. Chem. 270, 17442-17456
11. Johnson, E. S., Barrel, B., Seufert, W., and Varshavsky, A. (1992) EMBO J. 11, 497-505
12. Scherer, D. C., Brockman, J. A., Chen, Z., Maniatis, T., and Ballard, D. W. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11259-11263
13. Sokolik, C. W., and Cohen, R. E. (1992) J. Biol. Chem. 267, 1067-1071
14. Sherman, M. Y., and Goldberg, A. L. (2001) Neuron 29, 15-32
15. Kopito, R. R. (2000) Trends Cell Biol. 10, 524-530
16. VerPlank, L., Bouamr, F., LaGrassa, T. J., Agresta, B., Kikonyogo, A., Leis, J., and Carter, C. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 7724-7729
17. Yu, H., and Kopito, R. R. (1999) J. Biol. Chem. 274, 36852-36858
18. Terrell, J., Shih, S., Dunn, R., and Hicke, L. (1998) Mol. Cell 1, 193-202
19. Patnaik, A., Chau, V., and Wills, J. W. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 13069-13074
20. Shih, S. C., Sloper-Mould, K. R., and Hicka, L. (2000) EMBO J. 19, 187-198
21. Garrus, J. E., von Schwedler, U. K, Pormillos, O. W., Morham, S. G., Zavitz, K. H., Wang, H. E., Wettstein, D., Stray, K. M., Cote, M., Rich, R. L., Myszka, D. G., and Sundquist, W. I. (2001) Cell 107, 55-65
22. Roth, A. F., and Davis, N. G. (2000) J. Biol. Chem. 275, 8143-8153
23. Strack, B., Calistri, A., Accola, M. A., Palu, G., and Gottlinger, H. G. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 13063-13068
24. Hicke, L., and Riezman, H. (1996) Cell 84, 277-287
25. Ellison, M. J., and Hochstrasser, M. (1991) J. Biol. Chem. 266, 21150-21157
26. Roth, A. F., and Davis, N. G. (1996) J. Cell Biol. 134, 661-674
27. Beers, E. P., and Callis, J. (1993) J. Biol. Chem. 268, 21645-21649
28. Scheffner, M., Huibregtse, J. M., Vierstra, R. D., and Howley, P. M. (1993) Cell 75, 495-505
29. Lam, Y. A., Lawson, T. G., Velayutham, M., Zweier, J. L., and Pickart, C. M. (2002) Nature 416, 763-767
30. Townsend, A., Bastin, J., Gould, K., Brownlee, G., Andrew, M., Coupar, B., Boyle, D., Chan, S., and Smith, G. (1988) J. Exp. Med. 168, 1211-1224
31. Ott, D. E., Coren, L. V., Chertova, E. N., Gagliardi, T. D., and Schubert, U. (2000) Virology 278, 111-121
32. Porgador, A., Yewdell, J. W., Deng, Y., Bennink, J. R., and Germain, R. N. (1997) Immunity 6, 715-726
33. Schubert, U., Ott, D. E., Chertova, E. N., Welker, R., Tessmer, U., Princiotta, M. F., Bennink, J. R., Krausslich, H. G., and Yewdell, J. W. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 13057-13062
34. Fujimuro, M., Sawada, H., and Yokosawa, H. (1994) FEBS Lett. 349, 173-180
35. DeMartino, G. N., and Slaughter, C. A. (1999) J. Biol. Chem. 274, 22123-22126
36. Yewdell, J. W. (2001) Trends Cell Biol. 11, 294-297
37. Levy, F., Johnsson, N., Rumenapf, T., and Varshavsky, A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 4907-4912
38. Varshavsky, A. (2000) Methods Enzymol. 327, 578-593
39. Anton, L. C., Schubert, U., Bacik, I., Princiotta, M. F., Wearsch, P. A., Gibbs, J., Day, P. M., Realini, C., Rechsteiner, M. C., Bennink, J. R., and Yewdell, J. W. (1999) J. Cell Biol. 146, 113-124
40. Schubert, U., Anton, L. C., Gibbs, J., Norbury, C. C., Yewdell, J. W., and Bennink, J. R. (2000) Nature 404, 770-774
41. Thrower, J. S., Hoffman, L., Rechsteiner, M., and Pickart, C. M. (2000) EMBO J. 19, 94-102
42. Polo, S., Sigismund, S., Faretta, M., Guidi, M., Capua, M. R., Bossi, G., Chen, H., De Camilli, P., and Di Fiore, P. P. (2002) Nature 416, 451-455