Genomic structure and identification of a truncated variant message of the mouse estrogen receptor α gene

Gene

Volumn 294, Issue 1-2, 2002, Pages 239-247

  Swope, Deborah L ^a   Harrell, J Chuck ^a   Mahato, Dipak ^a   Korach, Kenneth S ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Estradiol; Splice variant; Steroid hormone receptor; Transcription

Indexed keywords

COMPLEMENTARY DNA; ESTROGEN RECEPTOR ALPHA;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXON; GENE; GENE IDENTIFICATION; GENE LIBRARY; GENE SEQUENCE; GENE STRUCTURE; GENETIC TRANSCRIPTION; INTRON; LIGAND BINDING; MAMMARY GLAND; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY; PLACENTA; PRIORITY JOURNAL; RESTRICTION FRAGMENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; TESTIS; UTERUS;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DNA, COMPLEMENTARY; ESTROGEN RECEPTOR ALPHA; EXONS; FEMALE; GENE EXPRESSION; GENES; INTRONS; MALE; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; RECEPTORS, ESTROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

ANIMALIA; RODENTIA;

EID: 0037055270     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(02)00796-5     Document Type: Article

References (30)

1. Bollig A., Miksicek R.J. An estrogen receptor-alpha splicing variant mediates both positive and negative effects on gene transcription. Mol. Endocrinol. 14:2000;634-649.
2. Burset M., Seledtsov I.A., Solovyev V.V. Analysis of canonical and non-canonical splice sites in mammalian genomes. Nucleic Acids Res. 28:2000;4364-4375.
3. Castles C.G., Fuqua S.A., Klotz D.M., Hill S.M. Expression of a constitutively active estrogen receptor variant in the estrogen receptor-negative BT-20 human breast cancer cell line. Cancer Res. 53:1993;5934-5939.
4. Chaidarun S.S., Alexander J.M. A tumor-specific truncated estrogen receptor splice variant enhances estrogen-stimulated gene expression. Mol. Endocrinol. 12:1998;1355-1366.
5. Couse J.F., Korach K.S. Reproductive phenotypes in the estrogen receptor-alpha knockout mouse. Ann. Endocrinol. (Paris). 60:1999;143-148.
6. Couse J.F., Davis V.L., Hanson R.B., Jefferson W.N., McLachlan J.A., Bullock B.C., Newbold R.R., Korach K.S. Accelerated onset of uterine tumors in transgenic mice with aberrant expression of the estrogen receptor after neonatal exposure to diethylstilbestrol. Mol. Carcinog. 19:1997;236-242.
7. Cowley S.M., Parker M.G. A comparison of transcriptional activation by ER alpha and ER beta. J. Steroid Biochem. Mol. Biol. 69:1999;165-175.
8. Enmark E., Pelto-Huikko M., Grandien K., Lagercrantz S., Lagercrantz J., Fried G., Nordenskjold M., Gustafsson J.A. Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. J. Clin. Endocrinol. Metab. 82:1997;4258-4265.
9. Escriva H., Delaunay F., Laudet V. Ligand binding and nuclear receptor evolution. Bioessays. 22:2000;717-727.
10. Fuqua S.A., Fitzgerald S.D., Chamness G.C., Tandon A.K., McDonnell D.P., Nawaz Z., O'Malley B.W., McGuire W.L. Variant human breast tumor estrogen receptor with constitutive transcriptional activity. Cancer Res. 51:1991;105-109.
11. Gallacchi P., Schoumacher F., Eppenberger-Castori S., Von Landenberg E.-M., Kueng W., Eppenberger U., Mueller H. Increased expression of estrogen-receptor exon-5-deletion variant in relapse tissues of human breast cancer. Int. J. Cancer. 79:1998;44-48.
12. Hood T.E., Calabrese E.J., Zuckerman B.M. Detection of an estrogen receptor in two nematode species and inhibition of binding and development by environmental chemicals. Ecotoxicol. Environ. Saf. 47:2000;74-81.
13. Ignar-Trowbridge D.M., Teng C.T., Ross K.A., Parker M.G., Korach K.S., McLachlan J.A. Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element. Mol. Endocrinol. 7:1993;992-998.
14. Jefferson W.N., Couse J.F., Banks E.P., Korach K.S., Newbold R.R. Expression of estrogen receptor beta is developmentally regulated in reproductive tissues of male and female mice. Biol. Reprod. 62:2000;310-317.
15. Kato S., Endoh H., Masuhiro Y., Kitamoto T., Uchiyama S., Sasaki H., Masushige S., Gotoh Y., Nishida E., Kawashima H., Metzger D., Chambon P. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science. 270:1995;1491-1494.
16. Korach K.S. Insights from the study of animals lacking functional estrogen receptor. Science. 266:1994;1524-1527.
17. Kos M., O'Brien S., Flouriot G., Gannon F. Tissue-specific expression of multiple mRNA variants of the mouse estrogen receptor alpha gene. FEBS Lett. 477:2000;15-20.
18. Krege J.H., Hodgin J.B., Couse J.F., Enmark E., Warner M., Mahler J.F., Sar M., Korach K.S., Gustafsson J.A., Smithies O. Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc. Natl. Acad. Sci. USA. 95:1998;15677-15682.
19. Le Roux M.G., Theze N., Wolff J., Le Pennec J.P. Organization of a rainbow trout estrogen receptor gene. Biochim. Biophys. Acta. 1172:1993;226-230.
20. Leygue E., Dotzlaw H., Watson P.H., Murphy L.C. Expression of estrogen receptor β1 β2, and β5 messenger RNAs in human breast tissue. Cancer Res. 59:1999;1175-1179.
21. Lu B., Dotzlaw H., Leygue E., Murphy L.J., Watson P.H., Murphy L.C. Estrogen receptor-alpha mRNA variants in murine and human tissues. Mol. Cell. Endocrinol. 158:1999;153-161.
22. Lubahn D.B., Moyer J.S., Golding T.S., Couse J.F., Korach K.S., Smithies O. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc. Natl. Acad. Sci. USA. 90:1993;11162-11166.
23. O'Farrell P.H. Developmental biology. Big genes and little genes and deadlines for transcription. Nature. 359:1992;366-367.
24. Pfeffer U., Fecarotta E., Arena G., Forlani A., Vidali G. Alternative splicing of the estrogen receptor primary transcript normally occurs in estrogen receptor positive tissues and cell lines. J. Steroid Biochem. Mol. Biol. 56:1996;99-105.
25. Ponglikitmongkol M., Green S., Chambon P. Genomic organization of the human oestrogen receptor gene. EMBO J. 7:1988;3385-3388.
26. Schuur E.R., McPherson L.A., Yang G.P., Weigel R.J. Genomic structure of the promoters of the human estrogen receptor-α gene demonstrate changes in chromatin structure induced by AP2g. J. Biol. Chem. 276:2001;15519-15526.
27. Shapiro M.B., Senapathy P. RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. Nucleic Acids Res. 15:1987;7155-7174.
28. Skynner M.J., Sim J.A., Herbison A.E. Detection of estrogen receptor alpha and beta messenger ribonucleic acids in adult gonadotropin-releasing hormone neurons. Endocrinology. 140:1999;5195-5201.
29. Weatherman R.V., Fletterick R.J., Scanlan T.S. Nuclear-receptor ligands and ligand-binding domains. Annu. Rev. Biochem. 68:1999;559-581.
30. White R., Lees J.A., Needham M., Ham J., Parker M. Structural organization and expression of the mouse estrogen receptor. Mol. Endocrinol. 1:1987;735-744.