Approach to establishing a liver targeting gene therapeutic vector using naturally occurring defective hepatitis B viruses devoid of immunogenic T cell epitope

Virus Research

Volumn 85, Issue 2, 2002, Pages 187-197

  Wang, Liqun ^a   Kaneko, Shuichi ^a   Honda, Masao ^a   Kobayashi, Kenichi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Gene therapy; Hepatitis B virus; Liver; Vector development

Indexed keywords

EPITOPE; GREEN FLUORESCENT PROTEIN; VIRUS VECTOR;

ARTICLE; CONTROLLED STUDY; DEFECTIVE VIRUS; GENE DELETION; GENE EXPRESSION; GENE SEQUENCE; GENE TARGETING; GENE THERAPY; GENETIC ANALYSIS; HEPATITIS; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IMMUNOGENICITY; LIVER; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; STRUCTURAL GENE; T LYMPHOCYTE; VIRION; VIRUS CULTURE; VIRUS REPLICATION;

CELL LINE; CELLS, CULTURED; DEFECTIVE VIRUSES; EPITOPES, T-LYMPHOCYTE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HEPATITIS B VIRUS; HEPATOCYTES; HUMANS; LIVER; LUMINESCENT PROTEINS; PEPTIDES; VIRUS REPLICATION;

DNA VIRUSES; HEPATITIS B VIRUS; INSERTION SEQUENCES;

EID: 0037053061     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1702(02)00043-6     Document Type: Article

References (46)

1. In vivo electroporetic transfer of bcl-2 antisense oligonucleotide inhibits the development of hepatocellular carcinoma in rats
2. In vitro infection of human hepatoma (HepG2) cells with hepatitis B virus
3. Development of replicative and nonreplicative hepatitis B virus vectors
4. Inhibition of cell proliferation in HCC-9204 hepatoma cells by a c-myc specific ribozyme
5. A third-generation lentivirus vector with a conditional packaging system
6. Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen
7. Liver-directed gene transfer vectors
8. An advance in liver-specific gene delivery
9. The hepatitis B virus seroconversion to anti-HBe is frequently associated with HBV genotype changes and selection of preS2-defective particles in chronically infected children
10. Liver-directed gene therapy: Promises, problems and prospects at the turn of the century
11. High yield preparation of isolated human adult hepatocytes by enzymatic perfusion of the liver
12. A novel method for efficient amplification of whole hepatitis B virus genomes permits rapid functional analysis and reveals deletion mutants in immunosuppressed patients
13. Replication of hepatitis B virus which carries foreign DNA in vitro
14. Differences in the entire nucleotide sequence between hepatitis B virus genomes from carriers positive for antibody to hepatitis B e antigen with and without active disease
15. Core antigen mutations of human hepatitis B virus in hepatomas accumulate in MHC class II-restricted T cell epitopes
16. Retroviral vectors for liver-directed gene therapy
17. Hammerhead ribozyme-mediated inhibition of telomerase activity in extracts of human hepatocellular carcinoma cells
18. Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors
19. Modulation of apoptosis, tumorigenesity and metastatic potential with antisense H-ras oligodeoxynucleotides in a high metastatic tumor model of hepatoma: LCI-D20
20. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells
21. Properties of hepatitis B virus pre-S1 deletion mutants
22. Nonrandom transduction of recombinant adeno-associated virus vectors in mouse hepatocytes in vivo: Cell cycling does not influence hepatocyte transduction
23. Immune response to hepatitis B virus core antigen (HBcAg): Localization of T cell recognition sites within HBcAg/HbeAg
24. Compact organization of the hepatitis B virus genome
25. Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: Evidence that T cells are directed against HBV core antigen expressed on hepatocytes
26. Trans-complementation among naturally occurring deletion mutants of hepatitis B virus and integrated viral DNA for the production of viral particles with mutant genomes in hepatoma cell lines
27. Interferon gene transfer by a hepatitis B virus vector efficiently suppresses wild-type virus infection
28. Pregenomic RNA encapsidation analysis of eleven missense and nonsense polymerase mutants of human hepatitis B virus
29. HBV-derived promoters direct liver-specific expression of an adenovirally transduced LDL receptor gene
30. Secretion of prebeta HDL increases with the suppression of cholesteryl ester transfer protein in Hep G2 cells
31. The hepatitis-B viruses: Molecular biology and recent tissue culture systems
32. Detection of specific sequences among DNA fragments separated by gel electrophoresis
33. Comparison of envelope and precore/core variants of hepatitis B virus (HBV) during chronic HBV infection
34. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
35. The assembly of very low density lipoproteins in rat hepatoma McA- RH7777 cells is inhibited by phospholipase A2 antagonists
36. Detection of pre-C and core region mutants of hepatitis B virus in chronic hepatitis B virus carriers
37. The HBV-producing cell line HepG2-4A5: A new in vitro system for studying the regulation of HBV replication and for screening anti- hepatitis B virus drugs
38. A potential therapeutic application of hairpin ribozymes: In vitro and in vivo studies of gene therapy for hepatitis C virus infection
39. Targeted inhibition of hepatitis C virus-directed gene expression in human hepatoma cell lines
40. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
41. A liver-specific enhancer in the core promoter region of human hepatitis B virus
42. The mechanism of natural occurrence of two closely linked HBV precore predominant mutations
43. A defective interference-like phenomenon of human hepatitis B virus in chronic carriers
44. A novel SV40-based vector successfully transduces and expresses an alpha 1-antitrypsin ribozyme in a human hepatoma-derived cell line
45. Analysis of hepatitis B virus genotypes and precore region variability during interferon treatment of HBe antigen negative chronic hepatitis B