In vivo electroporetic transfer of BCL-2 antisense oligonucleotide inhibits the development of hepatocellular carcinoma in rats

International Journal of Cancer

Volumn 85, Issue 2, 2000, Pages 260-266

  Baba, Miyako ^a   Iishi, Hiroyasu ^a   Tatsuta, Masaharu ^a  

^a OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GLUTATHIONE TRANSFERASE; LIPOSOME; MESSENGER RNA; NITROSOMORPHOLINE; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; ELECTROPORATION; GENE THERAPY; LIVER CELL CARCINOMA; LIVER HISTOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0034650673     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(20000115)85:2%3C260::AID-IJC18%3E3.0.CO;2-R     Document Type: Article

References (26)

1. AIHARA, H. and MIYAZAKI, J., Gene transfer into muscle by electroporation in vivo. Nature (Biotechnol.), 16, 867-870 (1998).
2. BISSONNETTE, R.P., ECHEVERRI, F., MAHNOUBI, A. and GREEN, D.R., Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature (Lond.), 359, 552-554 (1992).
3. CAMPOS, L., SABIDO, O., ROUAULT, J.-P. and GUYOTAT, D., Effects of bcl-2 antisense oligodeoxynucleotides on in vitro proliferation and survival of normal marrow progenitors and leukemic cells. Blood, 84, 595-600 (1994).
4. CRAIG, R.W., The bcl-2 gene family. Cancer Biol., 6, 35-43 (1995).
5. CHITTENBEN, T., HARRINGTON, E.A., O'CONNOR, R., FLEMINGTON, C., LUTZ, R.J., EVAN, G.I. and GUILD, B.C., Induction of apoptosis by the bcl-2 homologue bak. Nature (Lond.), 374, 733-736 (1995).
6. DESOIZE, B., Anticancer drug resistance and inhibition of apoptosis. Anticancer Res., 14, 2291-2294 (1994).
7. EVAN, G.I., WYLLIE, A.H., GILBERT, C.S., LITTLEWOOD, T.D., LAND, H., BROOKS, M., WATERS, C.M., PENN, L.Z. and HANCOCK, D.C., Induction of apoptosis in fibroblasts by c-myc protein. Cell, 69, 119-128 (1992).
8. FRIEND, D.S., PAPAHADJOPOULOS, D. and DEBS, R.J., Endocytosis and intracellular processing accompanying transfection mediated by cationic liposomes. Biochim. biophys. Acta, 1278, 41-50 (1996).
9. GRAMLICH, T., FRITSCH, C. and GANSLER, T., c-Myc amplification in hepatocellular carcinoma predicts unfavorable prognosis. Mod. Pathol., 9, 95-98 (1996).
10. HELLER, R., JAROSZESKI, M., ATKIN, A., MORADPOUR, D., GILBEST, R., WANDS, J. and NICOLAU, C., In vivo gene electroinjection and expression in rat liver. FEBS Lett., 389, 225-228 (1996).
11. INSTITUTE OF LABORATORY ANIMAL RESOURCES, Histologic typing of liver tumors of the rat. J. nat. Cancer Inst., 64, 177-207 (1980).
12. NAGAO, T., KONDO, Y., SATO, T., NAGATO, Y. and KONDO, Y., Immunohistochemical detection of aberrant p53 expression in hepatocellular carcinoma: correlation with cell proliferation activity indices, including mitotic index and MIB-1 immunostaining. Hum. Pathol., 26, 326-332 (1995).
13. OLTVAI, Z.N., MILLIMAN, C.L. and KORSMEYER, S.J., Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell, 74, 609-619 (1993).
14. REED, J.C., Bcl-2 and the regulation of programmed cell death. J. Cell Biol., 124, 1-6 (1994).
15. REED, J.C., Double identity for proteins of the bcl-2 family. Nature (Lond.), 387, 773-776 (1997a).
16. REED, J.C., Editorials: promise and problems of bcl-2 antisense therapy. J. nat. Cancer Inst., 89, 988-990 (1997b).
17. SATO, T., IRIS, S., KRAJEWSKI, S. and REED, J.C., Cloning and sequencing of a cDNA encoding the rat bcl-2 protein. Gene, 140, 291-292 (1994).
18. SCHOFIELD, J.P. and CASKEY, C.T., Non-viral approaches to gene therapy. Brit. med. Bull., 51, 56-71 (1995).
19. L protects cancer cells from p53-mediated apoptosis. Oncogene, 11, 1389-1394 (1995).
20. STINCHOCOMBE, S., BUCHMANN, A., BOCK, K.W. and SCHWARZ, M., Inhibition of apoptosis during 2,3,7,8-tetrachlorodibenzo-p-dioxin mediated tumour promotion in rat liver. Carcinogenesis, 16, 1271-1275 (1995).
21. TSUJIMOTO, Y., COSSMANN, J., JAFFE, E. and CROCE, C., Involvement of the bcl-2 gene in human follicular lymphoma. Science, 228, 1440-1443 (1985).
22. WAFI/CIPI in breast epithelial cells. Cancer Res., 55, 4520-4524 (1995).
23. L and bcl-2, displaces bax and promotes cell death. Cell, 80, 285-291 (1995).
24. YANG, J., LIU, X., BHALLA, K., KIM, C.N., IBRADO, A.M., CAI, J., PENG, T., JONES, D.P. and WANG, X., Prevention of apoptosis by bcl-2: release of cytochrome c from mitochondria blocked. Science, 275, 1129-1132 (1997).
25. ZEPPA, P., BENINCASA, G., FULCINITI, F., COCHAND-PRIOLLET, B., TRONCONE, G., VETRANI, A., CELENTANO, E., NARDONE, G. and PALOMBINI, L., Apoptosis and cytologic differentiation in hepatocellular carcinoma on fine needle aspiration samples. Acta Cytol., 40, 861-866 (1997).
26. ZIEGLER, A., LUEDKE, G.H., FABBRO, D., ALTMANN, K.H., STAHEL, R.A. and ZANGEMEISTER-WITTKE, U., Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the bcl-2 coding sequence. J. nat. Canrer Inst., 89, 1027-1036 (1997).