Picrotoxin and bicuculline have different effects on lumbar spinal networks and motoneurons in the neonatal rat

Brain Research

Volumn 935, Issue 1-2, 2002, Pages 81-86

  Pflieger, Jean François ^a   Clarac, François ^a   Vinay, Laurent ^a  

^a CNRS   (France)

Author keywords

Bicuculline; Central pattern generator; Disinhibition; GABAA receptor; Locomotion

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BICUCULLINE METHIODIDE; PICROTOXIN;

AFTERHYPERPOLARIZATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DRUG EFFECT; INTRACELLULAR RECORDING; LOCOMOTION; LUMBAR SPINE; MOTONEURON; MOTOR CONTROL; MOTOR COORDINATION; NERVE CELL NETWORK; NERVE CONDUCTION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; RHYTHM; VENTRAL ROOT;

2-AMINO-5-PHOSPHONOVALERATE; 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; BICUCULLINE; EXCITATORY AMINO ACID ANTAGONISTS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; INTERNEURONS; MOTOR NEURONS; NERVE NET; NEURAL INHIBITION; NEURAL PATHWAYS; PICROTOXIN; RATS; RATS, WISTAR; RECEPTORS, GABA-A; SPINAL CORD; SYNAPTIC TRANSMISSION;

EID: 0037052623     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)02469-1     Document Type: Article

References (26)

1. Endogenous activation of glycine and NMDA receptors in lamprey spinal cord during fictive locomotion
2. Slow dorsal-ventral rhythm generator in the lamprey spinal cord
3. Spontaneous rhythmic bursts induced by pharmacological block of inhibition in lumbar motoneurons of the neonatal rat spinal cord
4. GABAergic inactivation of the central pattern generators for locomotion in isolated neonatal rat spinal cord
5. Differential effects of potassium channel blockers on the activity of the locomotor network in neonatal rat
6. Strychnine eliminates alternating motor output during fictive locomotion in the lamprey
7. Effects of inhibitory amino acid antagonists on reciprocal inhibitory interactions during rhythmic motor activity in the in vitro neonatal rat spinal cord
8. Effect of bicuculline on thalamic activity: A direct blockade of IAHP in reticularis neurons
9. Calcium-dependent potassium channels play a critical role for burst termination in the locomotor network in lamprey
10. Spontaneous and locomotor-related GABAergic input onto primary afferents in the neonatal rat
11. Neural networks that co-ordinate locomotion and body orientation in lamprey
12. Coupling of spinal locomotor networks in larval lamprey revealed by receptor blockers for inhibitory amino acids: Neurophysiology and computer modeling
13. Membrane depolarization and prolongation of calcium-dependent action potentials of mouse neurons in cell culture by two convulsants: Bicuculline and penicillin
14. Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currents
15. Effects of inhibitory neurotransmitters on the mudpuppy (Necturus maculatus) locomotor pattern in vitro
16. Localization of the spinal network associated with generation of hindlimb locomotion in the neonatal rat and organization of its transverse coupling system
17. Effects of strychnine on fictive swimming in the lamprey: Evidence for glycinergic inhibition, discrepancies with model predictions, and novel modulatory rhythms
18. Spontaneous motoneuronal activity mediated by glycine and GABA in the spinal cord of rat fetuses in vitro
19. Recent advances in the pharmacology of quaternary salts of bicuculline
20. Evidence for a non-GABAergic action of quaternary salts of bicuculline on dopaminergic neurones
21. GABA synapses formed in vitro by local axon collaterals of nucleus accumbens neurons
22. Changes in the properties of developing glycine receptors in cultured mouse spinal neurons
23. The spinal GABA system modulates burst frequency and intersegmental coordination in the lamprey: Differential effects of GABAA and GABAB receptors
24. Antidromic discharges of dorsal root afferents in the neonatal rat
25. Antidromic discharges of dorsal root afferents and inhibition of the lumbar monosynaptic reflex in the neonatal rat
26. Multiple picrotoxinin effect on glycine channels in rat hippocampal neurons