Evidence for a non-GABAergic action of quaternary salts of bicuculline on dopaminergic neurones

Neuropharmacology

Volumn 36, Issue 11-12, 1997, Pages 1653-1657

  Seutin, V ^a   Scuvee Moreau J ^a   Dresse, A ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Afterhyperpolarization; Bicuculline; Dopaminergic neurones

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; APAMIN; BICUCULLINE; BICUCULLINE METHIODIDE; BICUCULLINE METHOCHLORIDE; MUSCIMOL; PICROTOXIN; TETRODOTOXIN;

AFTERHYPERPOLARIZATION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG EFFECT; INTRACELLULAR RECORDING; NERVE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BICUCULLINE; DOPAMINE; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; GABA ANTAGONISTS; MALE; MEMBRANE POTENTIALS; NEURONS; PATCH-CLAMP TECHNIQUES; PYRIDAZINES; RATS; RATS, WISTAR; RECEPTORS, GABA-A;

EID: 0344074647     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(97)00147-0     Document Type: Article

References (22)

1. + channels in hepatocytes and of nicotinic responses in skeletal muscle. European Journal of Pharmacology 236: 201-207.
2. Cherubini E., North R. A. and Williams J. T. (1988) Synaptic potentials in rat locus coeruleus neurones. J. Physiol. (Lond.) 406: 431-442.
3. Connelly S. T., Ping H.-Y. and Shepard P. D. (1996) Reversible blockade of an apamin-sensitive afterhyperpolarization by (+)-tubocurarine induces bursting activity in nigral dopamine neurone in vitro. Soc. Neurosci. Abstr. 22 (part 1): 358.
4. Cooper, J. R., Bloom, F. E. and Roth, R. H. (1986) The Biochemical Basis of Neuropharmacology. Oxford University Press, New York.
5. Curtis D. R., Duggan A. W., Felix D. and Johnston G. A. R. (1970) GABA, bicuculline and central inhibition. Nature 226: 1222-1224.
6. 125I] iodoglyburide in the rat brain. Neuroscience 52: 191-205.
7. Grace A. A. and Onn S.-P. (1989) Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro. J. Neurosci. 9: 3463-3481.
8. A antagonist, to rat brain membranes. J. Neurochem. 48: 1677-1686.
9. Heyer E. J., Nowak L. M. and Macdonald R. L. (1981) Bicuculline: a convulsant with synaptic and nonsynaptic actions. Neurology 31: 1381-1390.
10. Johnson S. W. and North R. A. (1992) Two types of neurone in the rat ventral tegmental area and their synaptic inputs. J. Physiol. (Lond.) 450: 455-468.
11. Johnson S. W. and Seutin V. (1997) Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currents. Neuroscience Letters 231: 13-16.
12. Köhler M., Hirschberg B., Bond C. T., Kinzie J. M., Marrion N. V., Maylie J. and Adelman J. P. (1996) Small-conductance, calcium-activated potassium channels from mammalian brain. Science 273: 1709-1714.
13. Mercuri N. B., Bonci A., Calabresi P., Stefani A. and Bernardi G. (1995) Properties of the hyperpolarization-activated cation current Ih in rat midbrain dopaminergic neurons. European Journal of Neuroscience 7: 462-469.
14. Newberry N. R. and Nicoll R. A. (1984) Direct hyperpolarizing action of baclofen on hippocampal pyramidal cells. Nature 308: 450-452.
15. Nicoll R. A. and Alger B. E. (1981) Synaptic excitation may activate a calcium-dependent potassium conductance in hippocampal pyramidal cells. Science 212: 957-959.
16. Olsen R. W., Ban M. and Miller T. (1976) Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Research 102: 283-299.
17. Seutin V., Johnson S. W. and North R. A. (1993) Apamin increases NMDA-induced burst firing of rat mesencephalic dopamine neurons. Brain Research 630: 341-344.
18. Seutin V., Johnson S. W. and North R. A. (1994) Effect of dopamine and baclofen on NMDA-induced burst firing in rat ventral tegmental neurons. Neuroscience 58: 201-206.
19. Seutin, V., Scuvée-Moreau, J. and Dresse, A. (1997) Bicuculline blocks the apamin-sensitive component of the afterhyperpolarization in rat dopamine neurons. Pflügers Arch. Eur. J. Physiol. 433, R7 (abstract).
20. + conductance. Experimental Brain Research 86: 141-150.
21. Yung W. H., Hausser M. A. and Jack J. J. B. (1991) Electrophysiology of dopaminergic and non-dopaminergic neurones of the guinea-pig substantia nigra pars compacta in vitro. J. Physiol. 436: 643-667.
22. Zhang Z.-W. and Feltz P. (1991) Bicuculline blocks nicotinic acetylcholine response in isolated intermediate lobe cells of the pig. British Journal of Pharmacology 102: 19-22.