Pictet-Spengler synthesis of tetrahydro-β-carbolines using vinylsulfonylmethyl resin

Tetrahedron Letters

Volumn 43, Issue 37, 2002, Pages 6661-6663

  Connors, Richard V ^a   Zhang, Alex J ^a   Shuttleworth, Stephen J ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; RESIN; TRYPTAMINE; TRYPTOLINE; UNCLASSIFIED DRUG; VINYLSULFONYLMETHYL RESIN;

ARTICLE; CHEMICAL PARAMETERS; CHEMICAL STRUCTURE; LIBRARY; SYNTHESIS;

EID: 0037048495     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(02)01341-2     Document Type: Article

References (17)

1. Pictet A., Spengler T. Chem. Ber. 44:1911;2030.
2. Cox E.D., Cook J.M. Chem. Rev. 95:1995;1797.
3. Groth T., Meldal M. J. Comb. Chem. 3:2001;45.
4. Kalijuste K., Undén A. Tetrahedron Lett. 36:1995;9211.
5. Yang L., Guo L. Tetrahedron Lett. 37:1996;5041.
6. Mohan R., Chou Y.-L., Morrissey M.M. Tetrahedron Lett. 37:1996;3963.
7. Mayer J.P., Bankaitis-Davis D., Zhang J., Beaton G., Bjergarde K., Andersen C.M., Goodman B.A., Herrera C.J. Tetrahedron Lett. 37:1996;5633.
8. Wang H., Ganesan A. Org. Lett. 1:1999;1647.
9. Dondas H.A., Grigg R., MacLachlan W.S., MacPherson D.T., Markandu J., Sridharan V., Suganthan S. Tetrahedron Lett. 41:2000;967.
10. Li X., Zhang L., Zhang W., Hall S.E., Tam J.P. Org. Lett. 2:2000;3075.
11. World Drug Index available from Derwent Information Systems Inc.
12. Kroll F.E.K., Morphy R., Rees D., Gani D. Tetrahedron Lett. 38:1997;8573.
13. Available from Novabiochem Inc.; catalogue number 01-64-0258.
14. Available from Robbins Scientific Inc.; see www.robsci.com.
15. An Agilent 1100 LC/MSD VL ESI system was used; percent conversions to desired products were determined at 254 nm.
16. A Genevac Series II HT4 centrifugal vacuum evaporator was employed; see www.genevac.com.
17. A Parallex Flex purification system from Biotage Inc. was employed; see www.biotage.com.