Regio- and stereo-selective biotransformation of 2α,5α,10β,14β-tetra-acetoxy-4(20), 11-taxadiene by Ginkgo cell suspension cultures

Tetrahedron

Volumn 58, Issue 28, 2002, Pages 5659-5668

  Dai, Jungui ^a   Ye, Min ^a   Guo, Hongzhu ^a   Zhu, Weihua ^b   Zhang, Dayong ^b   Hu, Qiu ^b   Zheng, Junhua ^a   Guo, Dean ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Biotransformation; Cell suspension cultures; Enzymes; Ginkgo biloba; Sinenxan A; Taxane

Indexed keywords

10BETA HYDROXY 2ALPHA,5ALPHA,9ALPHA,14BETA TETRAACETOXY 4(20),11 TAXADIENE FORMATE; 2ALPHA,5ALPHA,10BETA,14BETA TETRAACETOXY 4(20),11 TAXADIENE; 6ALPHA,10BETA DIHYDROXY 2ALPHA,5ALPHA,14BETA TRIACETOXY 4(20),11 TAXADIENE; 6ALPHA,9ALPHA,10BETA TRIHYDROXY 2ALPHA,5ALPHA,14BETA TRIACETOXY 4(20),11 TAXADIENE; 9ALPHA HYDROXY 2ALPHA,5ALPHA,10BETA,14BETA TETRAACETOXY 4(20),11 TAXADIENE; 9ALPHA HYDROXY 2ALPHA,5ALPHA,10BETA,14BETA TETRAACETOXY 4(20),11 TAXADIENE FORMATE; 9ALPHA,10BETA DIHYDROXY 2ALPHA,5ALPHA,14BETA TRIACETOXY 4(20),11 TAXADIENE; 9ALPHA,10BETA O (PROPANE 2,2 DIYL) 2ALPHA,5ALPHA,14BETA TRIACETOXY 4(20),11 TAXADIENE; 9ALPHA,14BETA DIHYDROXY 2ALPHA,5ALPHA,10BETA TRIACETOXY 4(20),11 TAXADIENE; GINKGO BILOBA EXTRACT; SINENXAN A; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL CULTURE; CELL GROWTH; CELL SUSPENSION; DRUG SYNTHESIS; DRUG TRANSFORMATION; ENZYME ACTIVITY; PLANT CELL; PRIORITY JOURNAL; STEREOCHEMISTRY;

GINKGO BILOBA; TAXUS;

EID: 0037043181     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(02)00529-X     Document Type: Article

References (36)