Biotransformation of 2α,5α,10β,14β-tetraacetoxy-4(20),11-taxadiene by the fungi Cunninghamella elegans and Cunninghamella echinulata

Journal of Natural Products

Volumn 59, Issue 11, 1996, Pages 1006-1009

  Hu, Shanghai ^a   Tian, Xufang ^a   Zhu, Weihua ^a   Fang, Qicheng ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DITERPENOID; TAXANE DERIVATIVE;

ARTICLE; BIOTRANSFORMATION; CANCER CHEMOTHERAPY; DRUG ISOLATION; DRUG METABOLISM; FUNGUS; HYDROXYLATION; NONHUMAN; STRUCTURE ANALYSIS;

EID: 0029906187     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np960112x     Document Type: Article

References (12)

1. The name Taxol was a common usage until recently, when it was trademarked by Bristol-Myers Squibb. Accordingly, each time the word Taxol is used in this manuscript, the trademark rights of Bristol-Myers Squibb are acknowledged.
2. Rowinsky, E. K.; Onetto, N.; Canetta, R. M.; Arbuck, S. G. Sem. Oncol. 1962, 19, 646-662.
3. Kingston, D. G. I. Pharmacol. Ther. 1991, 52, 1-34.
4. Monsarrat, B.; Mariel, E.; Gros, S.; Gares, M.; Guénard, D.; Guéritte-Voegelein, F.; Wright, M. Drug Metab. Dispos. 1990, 18, 895-901.
5. Walle, T.; Kumar; G. N.; McMillan, J. M.; Thornburg, K. R.; Walle, U. K. Biochem. Pharmacol. 1993, 46, 1661-1664.
6. Kumar, G. N.; Oatis, J. E.; Thornburg, K. R.; Heldrich, F. J.; Hazard, E. S.; Walle, T. Drug. Metab. Dispos. 1994, 22, 177-179.
7. Harris, J. W.; Katki, A.; Anderson, L. W.; Chmurny, G. N.; Paukstelis, J. V.; Collins, J. M. J. Med. Chem. 1994, 37, 706-709.
8. Hanson, R. L.; Wasylyk, J. M.; Nanduri, V. B.; Cazzulino, D. L.; Patel, R. N.; Szarka, L. J. J. Biol. Chem. 1994, 269, 22 145-22 149.
9. Chen, W. M.; Zhang, P. L.; Wu, B.; Zheng, Q. T. Acta Pharm. Sin. 1991, 26, 747-751.
10. Cheng, K. D.; Chen, W. M.; Zhu, W. H.; Fang, Q. C.; Liang, X. T.; Guo, J. Y. JP Appl. 92/249,047, 1992.
11. Ma, W. W.; Stahlhut, R. W.; Adams, T. L.; Gary, L. P.; Evans, W. A.; Blumenthal, S. G.; Gomez, G. A.; Nieder, M. H.; Hylands, P. J. J. Nat. Prod. 1994, 57, 1320-1324.
12. Hu, S. H.; Tian, X. F.; Zhu, W. H.; Fang, Q. C. Tetrahedron 1998, 52, 8739-8746.