PAR2 is Partout and now in the heart

Circulation Research

Volumn 90, Issue 4, 2002, Pages 366-368

  Maree, Andrew ^a   Fitzgerald, Desmond ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

Myocardial ischemia; Protease activated receptor; Reperfusion injury; Thrombin; Trypsin

Indexed keywords

CELL SURFACE RECEPTOR; CYTOKINE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 8; NITRIC OXIDE; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 1 AGONIST; PROTEINASE ACTIVATED RECEPTOR 2; THROMBIN; THROMBOCYTE ACTIVATING FACTOR; TRYPSIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VANILLOID RECEPTOR;

ATHEROSCLEROSIS; CORONARY ARTERY DISEASE; EDITORIAL; ENDOTHELIUM CELL; HEART MUSCLE ISCHEMIA; HUMAN; HUMAN CELL; INFLAMMATION; ISCHEMIC HEART DISEASE; MICROCIRCULATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; REPERFUSION INJURY; THROMBOCYTE ACTIVATION; THROMBOSIS; VASODILATATION;

AMINO ACID SUBSTITUTION; ANIMALS; CARDIOVASCULAR DISEASES; CORONARY CIRCULATION; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; GTP-BINDING PROTEINS; HUMANS; INFLAMMATION; MYOCARDIAL REPERFUSION INJURY; NERVE FIBERS; NITRIC OXIDE; ORGAN SPECIFICITY; RATS; RECEPTOR, PAR-1; RECEPTOR, PAR-2; RECEPTORS, THROMBIN; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; THROMBOSIS; VASODILATION;

EID: 0037040854     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000012906.85785.6A     Document Type: Editorial

References (20)

1. Peroxynitrite-induced cardiac myocyte injury
2. Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation: Selective preservation in ischemia/reperfusion injury: Involvement of lipoxygenase products, VR1 receptors, and C-fibers
3. How the protease thrombin talks to cells
4. Gene and locus structure and chromosomal localization of the protease-activated receptor gene family
5. The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling
6. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
7. Molecular cloning of a potential proteinase activated receptor
8. Mitogenic responses mediated through the proteinase-activated receptor-2 are induced by expressed forms of mast cell α- or β-tryptases
9. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
10. Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates
11. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells: Comparison with the thrombin receptor
12. Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo
13. Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw
14. Increased expression of protease-activated receptor-2 (PAR2) and PAR4 in human coronary artery by inflammatory stimuli unveils endothelium-dependent relaxations to PAR2 and PAR4 agonists
15. Ischemia-induced interleukin-8 release after human heart transplantation: A potential role for endothelial cells
16. Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart
17. Thrombin responses in human endothelial cells: Contributions from receptors other than PARI include the transactivation of PAR2 by thrombin-cleaved PAR1
18. Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway
19. Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1
20. A polymorphic protease-activated receptor 2 (PAR2) displaying reduced sensitivity to trypsin and differential responses to PAR agonists